Expression of dense-core vesicles and of their exocytosis are governed by the repressive transcription factor NRSF/REST

Annals of the New York Academy of Sciences

Volumn 1152, Issue , 2009, Pages 194-200

  D'Alessandro, Rosalba ^a   Klajn, Andrijana ^a   Meldolesi, Jacopo ^a,b,c,d  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c National Institute of Neuroscience   (Italy)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Chromogranin; Histone deacetylase; PC12; SNARE; Transcription

Indexed keywords

CHROMOGRANIN; HISTONE DEACETYLASE; SNARE PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRSF; UNCLASSIFIED DRUG;

ANIMAL CELL; CONFERENCE PAPER; EXOCYTOSIS; NEUROSECRETION; NEUROSECRETORY CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; SECRETORY VESICLE; WILD TYPE;

EID: 58549116920     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03988.x     Document Type: Conference Paper

References (25)

1. Takamori, S. et al. 2006. Molecular anatomy of a trafficking organelle. Cell 127 : 831 846.
2. Jahn, R. & R.H. Scheller. 2006. SNAREs-engines for membrane fusion. Nat. Rev. Mol. Cell. Biol. 7 : 631 643.
3. Schoenherr, C.J. & D.J. Anderson. 1995. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267 : 1360 1363.
4. Chong, J.A. et al. 1995. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80 : 949 957.
5. Ballas, N. & G. Mandel. 2005. The many faces of REST oversee epigenetic programming of neuronal genes. Curr. Opin. Neurobiol. 15 : 500 506.
6. Ooi, L. & I.C. Wood. 2007. Chromatin crosstalk in development and disease: lessons from REST. Nat. Rev. Genet. 8 : 544 554.
7. Bruce, A.W. et al. 2004. Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc. Natl. Acad. Sci. USA 101 : 10458 10463.
8. Mortazavi, A. et al. 2006. Comparative genomics modeling of the NRSF/REST repressor network: from single conserved sites to genome-wide repertoire. Genome. Res. 16 : 1208 1221.
9. Otto, S.J. et al. 2007. A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J. Neurosci. 27 : 6729 6739.
10. Johnson, D.S. et al. 2007. Genome-wide mapping of in vivo protein-DNA interactions. Science 316 : 1497 1502.
11. Bruce, A.W. et al. 2006. The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype. J. Neurochem. 98 : 1828 1840.
12. D'Alessandro, R. et al. 2008. Expression of the neurosecretory process in pc12 cells is governed by rest. J. Neurochem. 105 : 1369 1383.
13. Greene, L.A. & A.S. Tischler. 1976. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73 : 2424 2428.
14. Malosio, M.L. et al. 1999. Neurosecretory cells without neurosecretion: evidence of an independently regulated trait of the cell phenotype. J. Physiol. 520 (Pt 1 43 52.
15. Pance, A., F.J. Livesey & A.P. Jackson. 2006. A role for the transcriptional repressor REST in maintaining the phenotype of neurosecretory-deficient PC12 cells. J. Neurochem. 99 : 1435 1444.
16. Calderone, A. et al. 2003. Ischemic insults derepress the gene silencer REST in neurons destined to die. J. Neurosci. 23 : 2112 2121.
17. Guardavaccaro, D. et al. 2008. Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature 452 : 365 369.
18. Westbrook, T.F. et al. 2008. SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 452 : 370 374.
19. Leoni, C. et al. 1999. Neurite extension occurs in the absence of regulated exocytosis in PC12 subclones. Mol. Biol. Cell. 10 : 2919 2931.
20. Paquette, A.J., S.E. Perez & D.J. Anderson. 2000. Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo. Proc. Natl. Acad. Sci. USA 97 : 12318 12323.
21. Conaco, C. et al. 2006. Reciprocal actions of REST and a microRNA promote neuronal identity. Proc. Natl. Acad. Sci. USA 103 : 2422 2427.
22. Wu, J. & X. Xie. 2006. Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol. 7 : R85.
23. Visvanathan, J. et al. 2007. The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev. 21 : 744 749.
24. Westbrook, T.F. et al. 2005. A genetic screen for candidate tumor suppressors identifies REST. Cell 121 : 837 848.
25. Coulson, J.M. 2005. Transcriptional regulation: cancer, neurons and the REST. Curr. Biol. 15 : R665 R658.