High conductance sustained single-channel activity responsible for the low-threshold persistent Na+ current in entorhinal cortex neurons

Journal of Neuroscience

Volumn 19, Issue 17, 1999, Pages 7334-7341

  Magistretti, Jacopo ^a,b   Ragsdale, David S ^a   Alonso, Angel ^a  

^a MCGILL UNIVERSITY   (Canada)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

Entorhinal cortex; Na+ channel; Patch clamp; Persistent Na+ current; Rat; Single channel recording; Stellate cells; Temporal lobe

Indexed keywords

SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHANNEL GATING; DEPOLARIZATION; ENTORHINAL CORTEX; ION CONDUCTANCE; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SODIUM CURRENT; STELLATE CELL;

EID: 0033198253     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-17-07334.1999     Document Type: Article

References (49)

1. Aldrich RW, Corey DP, Stevens CF (1983) A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature 306:436-441.
2. Alonso A, García-Austt E (1987) Neuronal sources of theta rhythm in the entorhinal cortex of the rat. II. Phase relations between unit discharges and theta field potentials. Exp Brain Res 67:502-509.
3. +-dependent theta-like rhythmicity in stellate cells of entorhinal cortex layer II. Nature 342:175-177.
4. + current in pyramidal neurons from rat and cat sensorimotor cortex. J Neurosci 13:660-673.
5. Armstrong CM, Bezanilla F, Rojas E (1973) Destruction of sodium conductance inactivation in squid axons perfused with pronase. J Gen Physiol 62:375-391.
6. Attwell D, Cohen I, Eisner D, Ohba M, Ojeda C (1979) The steady state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres. Pflügers Arch 379:137-142.
7. Bland BH (1986) The physiology and pharmacology of hippocampal formation theta rhythms. Prog Neurobiol 26:1-54.
8. Crill WE (1996) Persistent sodium current in mammalian central neurons. Annu Rev Physiol 58:349-362.
9. + channels in planar lipid membranes. Pflügers Arch 419:514-521.
10. Cummins TR, Howe JR, Waxman SG (1998) Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel. J Neurosci 18:9607-9619.
11. Dickson CT, Alonso A (1997) Muscarinic induction of synchronous population activity in the entorhinal cortex. J Neurosci 17:6729-6744.
12. h in the generation of subthreshold membrane potential oscillations (MPOs) of entorhinal cortex (EC) layer II stellate cells. Soc Neurosci Abstr 24:2035.
13. Franceschetti S, Guatteo E, Panzica F, Sancini G, Wanke E, Avanzini G (1995) Ionic mechanisms underlying burst firing in pyramidal neurons: intracellular study in rat sensorimotor cortex. Brain Res 696:127-139.
14. French CR, Sah P, Buckett KS, Gage PW (1990) A voltage-dependent persistent sodium current in mammalian hippocampal neurons. J Gen Physiol 95:1139-1157.
15. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85-100.
16. Holscher C, Anwyl R, Rowan MJ (1997) Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation that can be depotentiated by stimulation on the negative phase in area CA1 in vivo. J Neurosci 17:6470-6477.
17. Isom LL, De Jong KS, Patton DE, Reber BFX, Offord J, Charbonneau T, Scheuer T, Catterall WA (1992) Primary structure and functional expression of the β1 subunit of the rat brain sodium channel. Science 256:839-842.
18. Joho RH, Moorman JR, VanDongen AM, Kirsch GE, Silberberg H, Schuster G, Brown AM (1990) Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes. Mol Brain Res 7:105-113.
19. Kirsch GE, Brown AM (1989) Kinetic properties of single sodium channels in rat heart and rat brain. J Gen Physiol 93:85-99.
20. Klink R, Alonso A (1993) Ionic mechanisms for the subthreshold oscillations and differential electroresponsiveness of medial entorhinal cortex layer II neurons. J Neurophysiol 70:144-157.
21. Klink R, Alonso A (1997) Muscarinic modulation of the oscillatory and repetitive firing properties of entorhinal cortex layer II neurons. J Neurophysiol 77:1813-1828.
22. Llinás RR, Sugimori M (1980) Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J Physiol (Lond) 305:197-213.
23. Ma JY, Catterall WA, Scheuer T (1997) Persistent sodium currents through brain sodium channels induced by G-protein βγ subunits. Neuron 19:443-452.
24. 2+ channels in apical dendrites of rat CA1 pyramidal neurons. J Physiol (Lond) 487:67-90.
25. Magistretti J, Alonso A (1999) Slow voltage-dependent inactivation of a sustained sodium current in stellate cells of rat entorhinal cortex layer II. In: Molecular and functional diversity of ion channels and receptors (Rudy B, Seeburg P, eds). Ann NY Acad Sci 868:84-88.
26. Magistretti J, de Curtis M (1998) Low-voltage activated T-type calcium currents are differently expressed in superficial and deep layers of guinea pig piriform cortex. J Neurophysiol 79:808-816.
27. Masukawa LM, Hansen AJ, Sheperd G (1991) Distribution of single-channel conductances in cultured rat hippocampal neurons. Cell Mol Neurobiol 11:231-243.
28. Moorman JR, Kirsch GE, VanDongen AMJ, Joho RH, Brown AM (1990) Fast and slow gating of sodium channels encoded by a single mRNA. Neuron 4:243-252.
29. Numann R, Catterall WA, Scheuer T (1991) Functional modulation of brain sodium channels by protein kinase C phosphorylation. Science 254:115-118.
30. Parri HR, Crunelli V (1998) Sodium current in rat and cat thalamocortical neurons: role of a non-inactivating component in tonic and burst firing. J Neurosci 18:854-867.
31. Patlak JB, Ortiz M (1985) Slow currents through single sodium channels of the adult rat heart. J Gen Physiol 86:89-104.
32. + channel currents in frog sartorius muscle. J Gen Physiol 87:305-326.
33. Ragsdale DS, Avoli M (1998) Sodium channels as molecular targets for antiepileptic drugs. Brain Res Rev 26:16-28.
34. Raman IM, Sprunger LK, Meisler MH, Bean BP (1997) Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron 19:881-891.
35. Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20:11-21.
36. Segal MM (1994) Endogenous bursts underlie seizurelike activity in solitary excitatory hippocampal neurons in microcultures. J Neurophysiol 72:1874-1884.
37. Segal MM, Douglas AF (1997) Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin. J Neurophysiol 77:3021-3034.
38. Silva LR, Amitai, Y, Connors, BW (1991) Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. Science 251:432-434.
39. Smith MR, Smith RD, Plummer NW, Meisler MH, Goldin AL (1998) Functional analysis of the mouse Scn8a sodium channel. J Neurosci 18:6093-6102.
40. Smith RD, Goldin AL (1998) Functional analysis of the rat I sodium channel in Xenopus oocytes. J Neurosci 18:811-820.
41. Squire LR, Zola SM (1996) Structure and function of declarative and nondeclarative memory systems. Proc Natl Acad Sci USA 93:13515-13522.
42. Stuart G, Sakmann B (1995) Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons. Neuron 15:1065-1076.
43. + conductance in rat optic nerve axons. Proc Natl Acad Sci USA 90:6976-6980.
44. + channel in cerebellar Purkinje cells has a single channel conductance distinct from the inactivating current. Soc Neurosci Abstr 20:63.
45. Suzuki W, Amaral DG (1994) Topographic organization of the reciprocal connections between the monkey entorhinal cortex and the perirhinal and parahippocampal cortices. J Neurosci 14:1856-1877.
46. + channels that fail to inactivate. Trends Neurosci 16:455-460.
47. + channels in excised membrane patches after modification by α-chymotrypsin. Biophys J 67:161-171.
48. Winson J (1978) Loss of hippocampal theta rhythm results in spatial memory deficit in the rat. Science 201:160-163.
49. Zhou JY, Potts JF, Trimmer JS, Agnew WS, Sigworth FJ (1991) Multiple gating modes and the effect of modulating factors on the mircol sodium channel. Neuron 7:775-785.