The role of basic amino acid surface clusters on the collagenase activity of cathepsin K

Biochemistry

Volumn 52, Issue 44, 2013, Pages 7742-7752

  Nallaseth, Ferez S ^a,c   Lecaille, Fabien ^a,d   Li, Zhenqiang ^a,e   Brömme, Dieter ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^d INSERM   (France)

^e ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; BASIC AMINO ACIDS; COLLAGENASE ACTIVITY; COLLAGENOLYTIC ACTIVITIES; GLYCOSAMINOGLYCANS; HIGH MOLECULAR WEIGHT; MUTATIONAL ANALYSIS; POSITIVELY CHARGED;

AMINO ACIDS; BINDING SITES; MAMMALS;

REDUCTION;

AMINO ACID; ARGININE; CATHEPSIN K; CHONDROITIN SULFATE; GLYCOSAMINOGLYCAN; LYSINE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SURFACE PROPERTY; WILD TYPE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; BINDING SITES; CATHEPSIN K; COLLAGEN; COLLAGENASES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUCOPROTEINS; SEQUENCE ALIGNMENT;

EID: 84887673573     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401051j     Document Type: Article

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