Conformational flexibility and allosteric regulation of cathepsin K

Biochemical Journal

Volumn 429, Issue 2, 2010, Pages 379-389

  Novinec, Marko ^a,b   Kovačič, Lidija ^c   Lenarĉič, Brigita ^b,c   Baici, Antonio ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

Chondroitin sulfate; Conformational change; Dermatan sulfate; Heparin; Non essential activation; Substrate inhibition

Indexed keywords

7-AMINO-4-METHYLCOUMARIN; ACTIVATION SUBSTRATE; ACTIVE SITE; ALLOSTERIC REGULATION; CHONDROITIN SULFATES; CONFORMATIONAL CHANGE; CONFORMATIONAL FLEXIBILITY; CYSTEINE PEPTIDASE; DERMATAN SULFATE; EXTRACELLULAR SPACE; GLYCOSAMINOGLYCANS; HOMOEOSTASIS; IN-VITRO; K-FUNCTION; KEY ENZYMES; KINETIC PROPERTIES; MOLECULAR LEVELS; MULTIPLE CONFORMATIONS; PHYSIOLOGICAL FUNCTIONS; STABILIZING EFFECTS; SULFATED GLYCOSAMINOGLYCANS;

BODY FLUIDS; ENZYME ACTIVITY; ENZYMES; IONIC STRENGTH; POLYSACCHARIDES; SUBSTRATES;

ENZYME INHIBITION;

BENZYLOXYCARBONYL PHENYLALANYLARGINYL 7 AMINO 4 METHYLCOUMARIN; CATHEPSIN K; CHONDROITIN SULFATE; COUMARIN DERIVATIVE; DERMATAN SULFATE; HEPARIN; STEFIN A; UNCLASSIFIED DRUG; COLLAGEN; CTSK PROTEIN, HUMAN; CYSTEINE PROTEINASE INHIBITOR; ELASTIN; GLYCOSAMINOGLYCAN; RECOMBINANT PROTEIN; TRYPTOPHAN;

ALLOSTERISM; ARTICLE; BLOOD PH; COLLAGEN DEGRADATION; CONFORMATION; CONTROLLED STUDY; ELASTOLYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; IN VITRO STUDY; IONIC STRENGTH; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; BLOOD; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYME STABILITY; KINETICS; METABOLISM; PH; PHYSIOLOGY; PROTEIN CONFORMATION; SPECTROFLUOROMETRY;

ALLOSTERIC REGULATION; ANIMALS; CATHEPSIN K; CATTLE; COLLAGEN; CYSTEINE PROTEINASE INHIBITORS; ELASTIN; ENZYME ACTIVATION; ENZYME STABILITY; GLYCOSAMINOGLYCANS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TRYPTOPHAN;

EID: 77954737401     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100337     Document Type: Article

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