Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions

Journal of Biological Chemistry

Volumn 286, Issue 11, 2011, Pages 8988-8998

  Cherney, Maia M ^a   Lecaille, Fabien ^b,c   Kienitz, Martin ^a   Nallaseth, Ferez S ^b,d   Li, Zhenqiang ^b,e   James, Michael N G ^a   Brömme, Dieter ^b,f  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITÉ DE TOURS   (France)

^d RUTGERS UNIVERSITY   (United States)

^e ImClone Systems   (United States)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINO ACID RESIDUES; ASYMMETRIC UNIT; CATHEPSIN L; CHONDROITIN; COLLAGENASE ACTIVITY; COMPLEX FORMATIONS; HEXASACCHARIDES; INHIBITORY EFFECT; MULTIPLE CONTACTS; STRUCTURAL ALTERATIONS; STRUCTURE-ACTIVITY; VARIANT MOLECULES; WILD TYPES;

AMINO ACIDS; DIMERS; ENZYME ACTIVITY; MOLECULES;

CRYSTAL STRUCTURE;

CATHEPSIN K; CHONDROITIN 4 SULFATE; DIMER; OLIGOMER;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; CATHEPSIN K; CHONDROITIN SULFATES; COLLAGENASES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MUTATION, MISSENSE; OSTEOCLASTS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953217030     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.126706     Document Type: Article

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