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Volumn 24, Issue 6, 2013, Pages 1078-1088

Vaccine design: Emerging concepts and renewed optimism

Author keywords

[No Author keywords available]

Indexed keywords

DELIVERY SYSTEMS; IMMUNE RESPONSE; IMMUNE SURVEILLANCE; MALARIA VACCINE; MEDICAL INTERVENTION; MOLECULAR INSIGHTS; PROTECTIVE IMMUNITIES; SYSTEMS BIOLOGY;

EID: 84887626348     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2013.02.015     Document Type: Review
Times cited : (30)

References (87)
  • 1
    • 84857785011 scopus 로고    scopus 로고
    • Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens
    • Watson D.S., Endsley A.N., Huang L. Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens. Vaccine 2012, 30:2256-2272. 10.1016/j.vaccine.2012.01.070.
    • (2012) Vaccine , vol.30 , pp. 2256-2272
    • Watson, D.S.1    Endsley, A.N.2    Huang, L.3
  • 2
    • 4644318756 scopus 로고    scopus 로고
    • Adenoviruses as vaccine vectors
    • Tatsis N., Ertl H.C. Adenoviruses as vaccine vectors. Mol Ther 2004, 10:616-629. 10.1016/j.ymthe.2004.07.013.
    • (2004) Mol Ther , vol.10 , pp. 616-629
    • Tatsis, N.1    Ertl, H.C.2
  • 3
    • 84866905923 scopus 로고    scopus 로고
    • Vaccines: self-amplifying RNA in lipid nanoparticles: a next-generation vaccine?
    • Flemming A. Vaccines: self-amplifying RNA in lipid nanoparticles: a next-generation vaccine?. Nat Rev Drug Discov 2012, 11:748-749. 10.1038/nrd3854.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 748-749
    • Flemming, A.1
  • 4
    • 78149277602 scopus 로고    scopus 로고
    • Scaffolding to build a rational vaccine design strategy
    • Burton D.R. Scaffolding to build a rational vaccine design strategy. Proc Natl Acad Sci U S A 2010, 107:17859-17860. 10.1073/pnas.1012923107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17859-17860
    • Burton, D.R.1
  • 5
    • 84860759632 scopus 로고    scopus 로고
    • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study
    • Haynes B.F., Kelsoe G., Harrison S.C., Kepler T.B. B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol 2012, 30:423-433. 10.1038/nbt.2197.
    • (2012) Nat Biotechnol , vol.30 , pp. 423-433
    • Haynes, B.F.1    Kelsoe, G.2    Harrison, S.C.3    Kepler, T.B.4
  • 6
    • 77958454595 scopus 로고    scopus 로고
    • Reverse vaccinology: developing vaccines in the era of genomics
    • Sette A., Rappuoli R. Reverse vaccinology: developing vaccines in the era of genomics. Immunity 2010, 33:530-541. 10.1016/j.immuni.2010.09.017.
    • (2010) Immunity , vol.33 , pp. 530-541
    • Sette, A.1    Rappuoli, R.2
  • 7
    • 84867397072 scopus 로고    scopus 로고
    • Developing vaccines in the era of genomics: a decade of reverse vaccinology
    • Seib K.L., Zhao X., Rappuoli R. Developing vaccines in the era of genomics: a decade of reverse vaccinology. Clin Microbiol Infect 2012, 18(Suppl 5):109-116. 10.1111/j.1469-0691.2012.03939.x.
    • (2012) Clin Microbiol Infect , vol.18 , Issue.SUPPL 5 , pp. 109-116
    • Seib, K.L.1    Zhao, X.2    Rappuoli, R.3
  • 11
    • 84887669298 scopus 로고    scopus 로고
    • A guide to in silico vaccine discovery for eukaryotic pathogens
    • [epub ahead of print]
    • Goodswen S.J., Kennedy P.J., Ellis J.T. A guide to in silico vaccine discovery for eukaryotic pathogens. Brief Bioinform 2012, [epub ahead of print]. 10.1093/bib/bbs066.
    • (2012) Brief Bioinform
    • Goodswen, S.J.1    Kennedy, P.J.2    Ellis, J.T.3
  • 18
    • 84887628614 scopus 로고    scopus 로고
    • Administration FaD. Guidance for Industry: Adaptive Design Clinical Trials for Drugs and Biologics, Draft Guidance. In Services USDoHaH
    • Administration FaD. Guidance for Industry: Adaptive Design Clinical Trials for Drugs and Biologics, Draft Guidance. In Services USDoHaH; 2010.
    • (2010)
  • 19
    • 79957627493 scopus 로고    scopus 로고
    • A 2020 vision for vaccines against HIV, tuberculosis and malaria
    • Rappuoli R., Aderem A. A 2020 vision for vaccines against HIV, tuberculosis and malaria. Nature 2011, 473:463-469. 10.1038/nature10124.
    • (2011) Nature , vol.473 , pp. 463-469
    • Rappuoli, R.1    Aderem, A.2
  • 20
    • 0032147015 scopus 로고    scopus 로고
    • Infant B cell responses to polysaccharide determinants
    • Rijkers G.T., Sanders E.A., Breukels M.A., Zegers B.J. Infant B cell responses to polysaccharide determinants. Vaccine 1998, 16:1396-1400.
    • (1998) Vaccine , vol.16 , pp. 1396-1400
    • Rijkers, G.T.1    Sanders, E.A.2    Breukels, M.A.3    Zegers, B.J.4
  • 21
    • 0030860733 scopus 로고    scopus 로고
    • The aging immune system: primary and secondary alterations of immune reactivity in the elderly
    • Wick G., Grubeck-Loebenstein B. The aging immune system: primary and secondary alterations of immune reactivity in the elderly. Exp Gerontol 1997, 32:401-413.
    • (1997) Exp Gerontol , vol.32 , pp. 401-413
    • Wick, G.1    Grubeck-Loebenstein, B.2
  • 22
    • 84865975048 scopus 로고    scopus 로고
    • A vaccine directed to B cells and produced by cell-free protein synthesis generates potent antilymphoma immunity
    • Ng P.P., Jia M., Patel K.G., Brody J.D., Swartz J.R., Levy S., Levy R. A vaccine directed to B cells and produced by cell-free protein synthesis generates potent antilymphoma immunity. Proc Natl Acad Sci U S A 2012, 109:14526-14531. 10.1073/pnas.1211018109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 14526-14531
    • Ng, P.P.1    Jia, M.2    Patel, K.G.3    Brody, J.D.4    Swartz, J.R.5    Levy, S.6    Levy, R.7
  • 23
    • 17144427675 scopus 로고    scopus 로고
    • Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens
    • Jones L.S., Peek L.J., Power J., Markham A., Yazzie B., Middaugh C.R. Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. J Biol Chem 2005, 280:13406-13414. 10.1074/jbc.M500687200.
    • (2005) J Biol Chem , vol.280 , pp. 13406-13414
    • Jones, L.S.1    Peek, L.J.2    Power, J.3    Markham, A.4    Yazzie, B.5    Middaugh, C.R.6
  • 24
    • 3042591219 scopus 로고    scopus 로고
    • Probing structural changes of proteins incorporated into water-in-oil emulsions
    • Jorgensen L., Van de Weert M., Vermehren C., Bjerregaard S., Frokjaer S. Probing structural changes of proteins incorporated into water-in-oil emulsions. J Pharm Sci 2004, 93:1847-1859. 10.1002/jps.20097.
    • (2004) J Pharm Sci , vol.93 , pp. 1847-1859
    • Jorgensen, L.1    Van de Weert, M.2    Vermehren, C.3    Bjerregaard, S.4    Frokjaer, S.5
  • 25
    • 78650576197 scopus 로고    scopus 로고
    • Use of defined TLR ligands as adjuvants within human vaccines
    • Duthie M.S., Windish H.P., Fox C.B., Reed S.G. Use of defined TLR ligands as adjuvants within human vaccines. Immunol Rev 2011, 239:178-196. 10.1111/j.1600-065X.2010.00978.x.
    • (2011) Immunol Rev , vol.239 , pp. 178-196
    • Duthie, M.S.1    Windish, H.P.2    Fox, C.B.3    Reed, S.G.4
  • 26
    • 80053255932 scopus 로고    scopus 로고
    • Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: findings, implications and open questions
    • Lang R., Schoenen H., Desel C. Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: findings, implications and open questions. Immunobiology 2011, 216:1184-1191. 10.1016/j.imbio.2011.06.005.
    • (2011) Immunobiology , vol.216 , pp. 1184-1191
    • Lang, R.1    Schoenen, H.2    Desel, C.3
  • 27
    • 79956314622 scopus 로고    scopus 로고
    • Immune signaling by RIG-I-like receptors
    • Loo Y.M., Gale M. Immune signaling by RIG-I-like receptors. Immunity 2011, 34:680-692. 10.1016/j.immuni.2011.05.003.
    • (2011) Immunity , vol.34 , pp. 680-692
    • Loo, Y.M.1    Gale, M.2
  • 30
    • 77957753966 scopus 로고    scopus 로고
    • Poly(I:C) is an effective adjuvant for antibody and multifunctional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and alphaDEC-CSP in non human primates
    • Tewari K., Flynn B.J., Boscardin S.B., Kastenmueller K., Salazar A.M., Anderson C.A., Soundarapandian V., Ahumada A., Keler T., Hoffman S.L., et al. Poly(I:C) is an effective adjuvant for antibody and multifunctional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and alphaDEC-CSP in non human primates. Vaccine 2010, 28:7256-7266. 10.1016/j.vaccine.2010.08.098.
    • (2010) Vaccine , vol.28 , pp. 7256-7266
    • Tewari, K.1    Flynn, B.J.2    Boscardin, S.B.3    Kastenmueller, K.4    Salazar, A.M.5    Anderson, C.A.6    Soundarapandian, V.7    Ahumada, A.8    Keler, T.9    Hoffman, S.L.10
  • 31
    • 84858591135 scopus 로고    scopus 로고
    • HIV-1 and influenza antigens synthetically linked to IgG2a Fc elicit superior humoral responses compared to unmodified antigens in mice
    • Zaharatos G.J., Yu J., Pace C., Song Y., Vasan S., Ho D.D., Huang Y. HIV-1 and influenza antigens synthetically linked to IgG2a Fc elicit superior humoral responses compared to unmodified antigens in mice. Vaccine 2011, 30:42-50. 10.1016/j.vaccine.2011.10.056.
    • (2011) Vaccine , vol.30 , pp. 42-50
    • Zaharatos, G.J.1    Yu, J.2    Pace, C.3    Song, Y.4    Vasan, S.5    Ho, D.D.6    Huang, Y.7
  • 33
    • 0027050013 scopus 로고
    • Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic
    • Kirnbauer R., Booy F., Cheng N., Lowy D.R., Schiller J.T. Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc Natl Acad Sci U S A 1992, 89:12180-12184.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 12180-12184
    • Kirnbauer, R.1    Booy, F.2    Cheng, N.3    Lowy, D.R.4    Schiller, J.T.5
  • 36
    • 84866664372 scopus 로고    scopus 로고
    • Immunization with M2e-displaying T7 bacteriophage nanoparticles protects against influenza A virus challenge
    • Hashemi H., Pouyanfard S., Bandehpour M., Noroozbabaei Z., Kazemi B., Saelens X., Mokhtari-Azad T. Immunization with M2e-displaying T7 bacteriophage nanoparticles protects against influenza A virus challenge. PLoS ONE 2012, 7:e45765. 10.1371/journal.pone.0045765.
    • (2012) PLoS ONE , vol.7
    • Hashemi, H.1    Pouyanfard, S.2    Bandehpour, M.3    Noroozbabaei, Z.4    Kazemi, B.5    Saelens, X.6    Mokhtari-Azad, T.7
  • 37
    • 84856397770 scopus 로고    scopus 로고
    • Reorienting our view of particle-based adjuvants for subunit vaccines
    • Little S.R. Reorienting our view of particle-based adjuvants for subunit vaccines. Proc Natl Acad Sci U S A 2012, 109:999-1000. 10.1073/pnas.1120993109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 999-1000
    • Little, S.R.1
  • 39
    • 80053161466 scopus 로고    scopus 로고
    • In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles
    • Jewell C.M., Lopez S.C., Irvine D.J. In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles. Proc Natl Acad Sci U S A 2011, 108:15745-15750. 10.1073/pnas.1105200108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 15745-15750
    • Jewell, C.M.1    Lopez, S.C.2    Irvine, D.J.3
  • 40
    • 79951899834 scopus 로고    scopus 로고
    • Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses
    • Moon J.J., Suh H., Bershteyn A., Stephan M.T., Liu H., Huang B., Sohail M., Luo S., Um S.H., Khant H., et al. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nat Mater 2011, 10:243-251. 10.1038/nmat2960.
    • (2011) Nat Mater , vol.10 , pp. 243-251
    • Moon, J.J.1    Suh, H.2    Bershteyn, A.3    Stephan, M.T.4    Liu, H.5    Huang, B.6    Sohail, M.7    Luo, S.8    Um, S.H.9    Khant, H.10
  • 42
    • 77952688015 scopus 로고    scopus 로고
    • Antibody-mediated protection against mucosal simian-human immunodeficiency virus challenge of macaques immunized with alphavirus replicon particles and boosted with trimeric envelope glycoprotein in MF59 adjuvant
    • Barnett S.W., Burke B., Sun Y., Kan E., Legg H., Lian Y., Bost K., Zhou F., Goodsell A., Zur Megede J., et al. Antibody-mediated protection against mucosal simian-human immunodeficiency virus challenge of macaques immunized with alphavirus replicon particles and boosted with trimeric envelope glycoprotein in MF59 adjuvant. J Virol 2010, 84:5975-5985. 10.1128/JVI. 02533-09.
    • (2010) J Virol , vol.84 , pp. 5975-5985
    • Barnett, S.W.1    Burke, B.2    Sun, Y.3    Kan, E.4    Legg, H.5    Lian, Y.6    Bost, K.7    Zhou, F.8    Goodsell, A.9    Zur Megede, J.10
  • 45
    • 79952809503 scopus 로고    scopus 로고
    • Surface functionalization of virus-like particles by direct conjugation using azide-alkyne click chemistry
    • Patel K.G., Swartz J.R. Surface functionalization of virus-like particles by direct conjugation using azide-alkyne click chemistry. Bioconjug Chem 2011, 22:376-387. 10.1021/bc100367u.
    • (2011) Bioconjug Chem , vol.22 , pp. 376-387
    • Patel, K.G.1    Swartz, J.R.2
  • 46
    • 84868091682 scopus 로고    scopus 로고
    • Cell-free production of trimeric influenza hemagglutinin head domain proteins as vaccine antigens
    • Welsh J.P., Lu Y., He X.S., Greenberg H.B., Swartz J.R. Cell-free production of trimeric influenza hemagglutinin head domain proteins as vaccine antigens. Biotechnol Bioeng 2012, 109:2962-2969. 10.1002/bit.24581.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 2962-2969
    • Welsh, J.P.1    Lu, Y.2    He, X.S.3    Greenberg, H.B.4    Swartz, J.R.5
  • 47
    • 84863517708 scopus 로고    scopus 로고
    • Ranking viruses: measures of positional importance within networks define core viruses for rational polyvalent vaccine development
    • Anderson T.K., Laegreid W.W., Cerutti F., Osorio F.A., Nelson E.A., Christopher-Hennings J., Goldberg T.L. Ranking viruses: measures of positional importance within networks define core viruses for rational polyvalent vaccine development. Bioinformatics 2012, 28:1624-1632. 10.1093/bioinformatics/bts181.
    • (2012) Bioinformatics , vol.28 , pp. 1624-1632
    • Anderson, T.K.1    Laegreid, W.W.2    Cerutti, F.3    Osorio, F.A.4    Nelson, E.A.5    Christopher-Hennings, J.6    Goldberg, T.L.7
  • 49
    • 77953520516 scopus 로고    scopus 로고
    • MHC class II epitope predictive algorithms
    • Nielsen M., Lund O., Buus S., Lundegaard C. MHC class II epitope predictive algorithms. Immunology 2010, 130:319-328. 10.1111/j.1365-2567.2010.03268.x.
    • (2010) Immunology , vol.130 , pp. 319-328
    • Nielsen, M.1    Lund, O.2    Buus, S.3    Lundegaard, C.4
  • 50
    • 83155164579 scopus 로고    scopus 로고
    • Predictions versus high-throughput experiments in T-cell epitope discovery: competition or synergy?
    • Lundegaard C., Lund O., Nielsen M. Predictions versus high-throughput experiments in T-cell epitope discovery: competition or synergy?. Expert Rev Vaccines 2012, 11:43-54. 10.1586/erv.11.160.
    • (2012) Expert Rev Vaccines , vol.11 , pp. 43-54
    • Lundegaard, C.1    Lund, O.2    Nielsen, M.3
  • 51
    • 78149357976 scopus 로고    scopus 로고
    • A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes
    • Hartman I.Z., Kim A., Cotter R.J., Walter K., Dalai S.K., Boronina T., Griffith W., Lanar D.E., Schwenk R., Krzych U., et al. A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes. Nat Med 2010, 16:1333-1340. 10.1038/nm.2248.
    • (2010) Nat Med , vol.16 , pp. 1333-1340
    • Hartman, I.Z.1    Kim, A.2    Cotter, R.J.3    Walter, K.4    Dalai, S.K.5    Boronina, T.6    Griffith, W.7    Lanar, D.E.8    Schwenk, R.9    Krzych, U.10
  • 54
    • 84860837935 scopus 로고    scopus 로고
    • Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens
    • Santra S., Muldoon M., Watson S., Buzby A., Balachandran H., Carlson K.R., Mach L., Kong W.P., McKee K., Yang Z.Y., et al. Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens. Virology 2012, 428:121-127. 10.1016/j.virol.2012.03.012.
    • (2012) Virology , vol.428 , pp. 121-127
    • Santra, S.1    Muldoon, M.2    Watson, S.3    Buzby, A.4    Balachandran, H.5    Carlson, K.R.6    Mach, L.7    Kong, W.P.8    McKee, K.9    Yang, Z.Y.10
  • 56
    • 78049304748 scopus 로고    scopus 로고
    • Adaptive evolution of the Chlamydia trachomatis dominant antigen reveals distinct evolutionary scenarios for B- and T-cell epitopes: worldwide survey
    • Nunes A., Nogueira P.J., Borrego M.J., Gomes J.P. Adaptive evolution of the Chlamydia trachomatis dominant antigen reveals distinct evolutionary scenarios for B- and T-cell epitopes: worldwide survey. PLoS ONE 2010, 5. 10.1371/journal.pone.0013171.
    • (2010) PLoS ONE , vol.5
    • Nunes, A.1    Nogueira, P.J.2    Borrego, M.J.3    Gomes, J.P.4
  • 57
    • 77951030492 scopus 로고    scopus 로고
    • Genotype 1 and global hepatitis C T-cell vaccines designed to optimize coverage of genetic diversity
    • Yusim K., Fischer W., Yoon H., Thurmond J., Fenimore P.W., Lauer G., Korber B., Kuiken C. Genotype 1 and global hepatitis C T-cell vaccines designed to optimize coverage of genetic diversity. J Gen Virol 2010, 91:1194-1206. 10.1099/vir.0.017491-0.
    • (2010) J Gen Virol , vol.91 , pp. 1194-1206
    • Yusim, K.1    Fischer, W.2    Yoon, H.3    Thurmond, J.4    Fenimore, P.W.5    Lauer, G.6    Korber, B.7    Kuiken, C.8
  • 58
    • 0033046472 scopus 로고    scopus 로고
    • Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses
    • Yewdell J.W., Bennink J.R. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses. Annu Rev Immunol 1999, 17:51-88. 10.1146/annurev.immunol.17.1.51.
    • (1999) Annu Rev Immunol , vol.17 , pp. 51-88
    • Yewdell, J.W.1    Bennink, J.R.2
  • 59
    • 34250363053 scopus 로고    scopus 로고
    • Pathogenic epitopes, heterologous immunity and vaccine design
    • Welsh R.M., Fujinami R.S. Pathogenic epitopes, heterologous immunity and vaccine design. Nat Rev Microbiol 2007, 5:555-563. 10.1038/nrmicro1709.
    • (2007) Nat Rev Microbiol , vol.5 , pp. 555-563
    • Welsh, R.M.1    Fujinami, R.S.2
  • 60
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011, 29:621-663. 10.1146/annurev-immunol-031210-101400.
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 62
    • 84856387516 scopus 로고    scopus 로고
    • Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction
    • Moon J.J., Suh H., Li A.V., Ockenhouse C.F., Yadava A., Irvine D.J. Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction. Proc Natl Acad Sci U S A 2012, 109:1080-1085. 10.1073/pnas.1112648109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 1080-1085
    • Moon, J.J.1    Suh, H.2    Li, A.V.3    Ockenhouse, C.F.4    Yadava, A.5    Irvine, D.J.6
  • 64
    • 83055188639 scopus 로고    scopus 로고
    • T-cell-inducing vaccines-what's the future
    • Gilbert S.C. T-cell-inducing vaccines-what's the future. Immunology 2012, 135:19-26. 10.1111/j.1365-2567.2011.03517.x.
    • (2012) Immunology , vol.135 , pp. 19-26
    • Gilbert, S.C.1
  • 65
    • 77954357410 scopus 로고    scopus 로고
    • Correlates of protection induced by vaccination
    • Plotkin S.A. Correlates of protection induced by vaccination. Clin Vaccine Immunol 2010, 17:1055-1065. 10.1128/CVI. 00131-10.
    • (2010) Clin Vaccine Immunol , vol.17 , pp. 1055-1065
    • Plotkin, S.A.1
  • 66
    • 84869177341 scopus 로고    scopus 로고
    • Structural vaccinology starts to deliver
    • Dormitzer P.R., Grandi G., Rappuoli R. Structural vaccinology starts to deliver. Nat Rev Microbiol 2012, 10:807-813. 10.1038/nrmicro2893.
    • (2012) Nat Rev Microbiol , vol.10 , pp. 807-813
    • Dormitzer, P.R.1    Grandi, G.2    Rappuoli, R.3
  • 67
    • 79953181620 scopus 로고    scopus 로고
    • A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination
    • Beernink P.T., Shaughnessy J., Braga E.M., Liu Q., Rice P.A., Ram S., Granoff D.M. A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination. J Immunol 2011, 186:3606-3614. 10.4049/jimmunol.1003470.
    • (2011) J Immunol , vol.186 , pp. 3606-3614
    • Beernink, P.T.1    Shaughnessy, J.2    Braga, E.M.3    Liu, Q.4    Rice, P.A.5    Ram, S.6    Granoff, D.M.7
  • 70
    • 79959338198 scopus 로고    scopus 로고
    • Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers
    • Swanson K.A., Settembre E.C., Shaw C.A., Dey A.K., Rappuoli R., Mandl C.W., Dormitzer P.R., Carfi A. Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers. Proc Natl Acad Sci U S A 2011, 108:9619-9624. 10.1073/pnas.1106536108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 9619-9624
    • Swanson, K.A.1    Settembre, E.C.2    Shaw, C.A.3    Dey, A.K.4    Rappuoli, R.5    Mandl, C.W.6    Dormitzer, P.R.7    Carfi, A.8
  • 71
    • 80052882697 scopus 로고    scopus 로고
    • A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide(R) ISA 720
    • McCarthy J.S., Marjason J., Elliott S., Fahey P., Bang G., Malkin E., Tierney E., Aked-Hurditch H., Adda C., Cross N., et al. A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide(R) ISA 720. PLoS ONE 2011, 6:e24413. 10.1371/journal.pone.0024413.
    • (2011) PLoS ONE , vol.6
    • McCarthy, J.S.1    Marjason, J.2    Elliott, S.3    Fahey, P.4    Bang, G.5    Malkin, E.6    Tierney, E.7    Aked-Hurditch, H.8    Adda, C.9    Cross, N.10
  • 72
    • 85046915383 scopus 로고    scopus 로고
    • The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development
    • Hviid L. The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development. Hum Vaccin 2010, 6:84-89.
    • (2010) Hum Vaccin , vol.6 , pp. 84-89
    • Hviid, L.1
  • 73
    • 80053236891 scopus 로고    scopus 로고
    • Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial
    • Asante K.P., Abdulla S., Agnandji S., Lyimo J., Vekemans J., Soulanoudjingar S., Owusu R., Shomari M., Leach A., Jongert E., et al. Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial. Lancet Infect Dis 2011, 11:741-749. 10.1016/S1473-3099(11)70100-1.
    • (2011) Lancet Infect Dis , vol.11 , pp. 741-749
    • Asante, K.P.1    Abdulla, S.2    Agnandji, S.3    Lyimo, J.4    Vekemans, J.5    Soulanoudjingar, S.6    Owusu, R.7    Shomari, M.8    Leach, A.9    Jongert, E.10
  • 77
    • 84869075297 scopus 로고    scopus 로고
    • A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin
    • Schneemann A., Speir J.A., Tan G.S., Khayat R., Ekiert D.C., Matsuoka Y., Wilson I.A. A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin. J Virol 2012, 86:11686-11697. 10.1128/JVI. 01694-12.
    • (2012) J Virol , vol.86 , pp. 11686-11697
    • Schneemann, A.1    Speir, J.A.2    Tan, G.S.3    Khayat, R.4    Ekiert, D.C.5    Matsuoka, Y.6    Wilson, I.A.7
  • 78
    • 77649242815 scopus 로고    scopus 로고
    • Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins
    • Wang T.T., Tan G.S., Hai R., Pica N., Petersen E., Moran T.M., Palese P. Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. PLoS Pathog 2010, 6:e1000796. 10.1371/journal.ppat.1000796.
    • (2010) PLoS Pathog , vol.6
    • Wang, T.T.1    Tan, G.S.2    Hai, R.3    Pica, N.4    Petersen, E.5    Moran, T.M.6    Palese, P.7
  • 81
    • 79958059341 scopus 로고    scopus 로고
    • Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus
    • McLellan J.S., Correia B.E., Chen M., Yang Y., Graham B.S., Schief W.R., Kwong P.D. Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus. J Mol Biol 2011, 409:853-866. 10.1016/j.jmb.2011.04.044.
    • (2011) J Mol Biol , vol.409 , pp. 853-866
    • McLellan, J.S.1    Correia, B.E.2    Chen, M.3    Yang, Y.4    Graham, B.S.5    Schief, W.R.6    Kwong, P.D.7
  • 87
    • 84861324362 scopus 로고    scopus 로고
    • HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopes
    • Tong T., Crooks E.T., Osawa K., Binley J.M. HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopes. J Virol 2012, 86:3574-3587. 10.1128/JVI. 06938-11.
    • (2012) J Virol , vol.86 , pp. 3574-3587
    • Tong, T.1    Crooks, E.T.2    Osawa, K.3    Binley, J.M.4


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