-
1
-
-
78149242586
-
Elicitation of structure-specific antibodies by epitope scaffolds
-
Ofek G, et al. (2010) Elicitation of structure-specific antibodies by epitope scaffolds. Proc Natl Acad Sci USA 107:17880-17887.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 17880-17887
-
-
Ofek, G.1
-
3
-
-
0036719574
-
Antibodies, viruses and vaccines
-
Burton DR (2002) Antibodies, viruses and vaccines. Nat Rev Immunol 2:706-713.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 706-713
-
-
Burton, D.R.1
-
5
-
-
0027378573
-
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1
-
Muster T, et al. (1993) A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1. J Virol 67:6642-6647.
-
(1993)
J Virol
, vol.67
, pp. 6642-6647
-
-
Muster, T.1
-
6
-
-
73949154006
-
Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L
-
Hessell AJ, et al. (2010) Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. J Virol 84:1302-1313.
-
(2010)
J Virol
, vol.84
, pp. 1302-1313
-
-
Hessell, A.J.1
-
7
-
-
0034759882
-
Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41
-
Zwick MB, et al. (2001) Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41. J Virol 75:10892-10905.
-
(2001)
J Virol
, vol.75
, pp. 10892-10905
-
-
Zwick, M.B.1
-
8
-
-
4544379899
-
Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its epitope
-
Ofek G, et al. (2004) Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its epitope. J Virol 78:10724-10737.
-
(2004)
J Virol
, vol.78
, pp. 10724-10737
-
-
Ofek, G.1
-
9
-
-
0008273311
-
Fab′-epitope complex from the HIV-1 cross-neutralizing monoclonal antibody 2F5
-
World Intellectual Property Organization. Patent WO-00/61618
-
Pai EF, Klein MH, Chong P, Pedyczak A (2000) Fab′-epitope complex from the HIV-1 cross-neutralizing monoclonal antibody 2F5. World Intellectual Property Organization. Patent WO-00/61618.
-
(2000)
-
-
Pai, E.F.1
Klein, M.H.2
Chong, P.3
Pedyczak, A.4
-
10
-
-
54849416088
-
Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: Epitope conformation, antigen-recognition loop mobility, and anion-binding site
-
Julien JP, Bryson S, Nieva JL, Pai EF (2008) Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: Epitope conformation, antigen-recognition loop mobility, and anion-binding site. J Mol Biol 384:377-392.
-
(2008)
J Mol Biol
, vol.384
, pp. 377-392
-
-
Julien, J.P.1
Bryson, S.2
Nieva, J.L.3
Pai, E.F.4
-
11
-
-
12144285761
-
The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5
-
Zwick MB, et al. (2004) The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5. J Virol 78:3155-3161.
-
(2004)
J Virol
, vol.78
, pp. 3155-3161
-
-
Zwick, M.B.1
-
12
-
-
77950803157
-
Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding
-
Julien JP, et al. (2010) Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding. J Virol 84:4136-4147.
-
(2010)
J Virol
, vol.84
, pp. 4136-4147
-
-
Julien, J.P.1
-
13
-
-
77649132440
-
Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region
-
Ofek G, et al. (2010) Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region. J Virol 84:2955-2962.
-
(2010)
J Virol
, vol.84
, pp. 2955-2962
-
-
Ofek, G.1
-
14
-
-
21344434534
-
Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
-
Haynes BF, et al. (2005) Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science 308:1906-1908.
-
(2005)
Science
, vol.308
, pp. 1906-1908
-
-
Haynes, B.F.1
-
15
-
-
37349058177
-
Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity
-
DOI 10.1097/QAD.0b013e3282a4a632, PII 0000203020071018000002
-
Scherer EM, Zwick MB, Teyton L, Burton DR (2007) Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity. AIDS 21:2131-2139. (Pubitemid 350287210)
-
(2007)
AIDS
, vol.21
, Issue.16
, pp. 2131-2139
-
-
Scherer, E.M.1
Zwick, M.B.2
Teyton, L.3
Burton, D.R.4
-
16
-
-
77951296711
-
Confocal microscopy of giant vesicles supports the absence of HIV-1 neutralizing 2F5 antibody reactivity to plasma membrane phospholipids
-
Apellaniz B, et al. (2010) Confocal microscopy of giant vesicles supports the absence of HIV-1 neutralizing 2F5 antibody reactivity to plasma membrane phospholipids. FEBS Lett 584:1591-1596.
-
(2010)
FEBS Lett
, vol.584
, pp. 1591-1596
-
-
Apellaniz, B.1
-
17
-
-
60549089534
-
Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1
-
Matyas GR, Beck Z, Karasavvas N, Alving CR (2009) Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1. Biochim Biophys Acta 1788:660-665.
-
(2009)
Biochim Biophys Acta
, vol.1788
, pp. 660-665
-
-
Matyas, G.R.1
Beck, Z.2
Karasavvas, N.3
Alving, C.R.4
-
18
-
-
67049156802
-
Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface
-
Song L, et al. (2009) Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface. Proc Natl Acad Sci USA 106:9057-9062.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 9057-9062
-
-
Song, L.1
-
19
-
-
77956317558
-
Computational design of epitope- scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope
-
Correia BE, et al. (2010) Computational design of epitope- scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope. Structure 18:1116-1126.
-
(2010)
Structure
, vol.18
, pp. 1116-1126
-
-
Correia, B.E.1
-
20
-
-
0035701421
-
A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1
-
DOI 10.1089/08892220152741450
-
Stiegler G, et al. (2001) A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses 17:1757-1765. (Pubitemid 34114213)
-
(2001)
AIDS Research and Human Retroviruses
, vol.17
, Issue.18
, pp. 1757-1765
-
-
Stiegler, G.1
Kunert, R.2
Purtscher, M.3
Wolbank, S.4
Voglauer, R.5
Steindl, F.6
Katinger, H.7
-
21
-
-
13844255333
-
Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41
-
Cardoso RM, et al. (2005) Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. Immunity 22:163-173.
-
(2005)
Immunity
, vol.22
, pp. 163-173
-
-
Cardoso, R.M.1
|