Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS)

Gene

Volumn 533, Issue 2, 2014, Pages 554-557

  Ben Salem, A ^a   Ajina, M ^b   Suissi, M ^c   Daher, H S ^d   Almawi, W Y ^d   Mahjoub, T ^a  

^a UNIVERSITY OF MONASTIR   (Tunisia)

^b FARHAT HACHED HOSPITAL   (Tunisia)

^c CHU Tahar Sfar   (Tunisia)

^d ARABIAN GULF UNIVERSITY   (Bahrain)

Author keywords

Insulin resistance; PCOS; Replication; TCF7L2

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRANSCRIPTION FACTOR 7 LIKE 2; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HUMAN; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL; TUNISIA;

BMI; BODY-MASS INDEX; HARDY-WEINBERG EQUILIBRIUM; HOMA-IR; HOMEOSTASIS MODEL ASSESSMENT FOR INSULIN RESISTANCE; HWE; INSULIN RESISTANCE; MAF; MINOR ALLELE FREQUENCY; PCOS; POLYCYSTIC OVARY SYNDROME; REPLICATION; SINGLE NUCLEOTIDE POLYMORPHISM; SNP; T2DM; TCF7L2; TRANSCRIPTION FACTOR-7-LIKE 2; TYPE 2 DIABETES;

ADULT; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; TUNISIA; YOUNG ADULT;

EID: 84887613963     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.09.104     Document Type: Article

References (41)

1. Amir A.L., Barua M., McKnight N.C., Cheng S., Yuan X., Balk S.P. A direct β-catenin-independent interaction between androgen receptor and T cell factor 4. J. Biol. Chem. 2003, 278:30828-30834.
2. Azziz R., et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil. Steril. 2009, 96:456-488.
3. Barber T.M., et al. Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS. Diabetologia 2007, 50:2318-2322.
4. Bhattacharya S.M. Abnormal glucose tolerance in polycystic ovary syndrome. J. Obstet. Gynaecol. Res. 2008, 34:228-232.
5. Biyasheva A., Legro R.S., Dunaif A., Urbanek M. Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2. J. Clin. Endocrinol. Metab. 2009, 94:2617-2625.
6. Book C.B., Dunaif A. Selective insulin resistance in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 1999, 84:3110-3116.
7. Christopoulos P., et al. Genetic variants in TCF7L2 and KCNJ11 genes in a Greek population with polycystic ovary syndrome. Gynecol. Endocrinol. 2008, 24:486-490.
8. Dunaif A., Finegood D.T. Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 1996, 81:942-947.
9. Duval A., Busson-Leconiat M., Berger R., Hamelin R. Assignment of the TCF-4 gene (TCF7L2) to human chromosome band 10q25.3. Cytogenet. Cell Genet. 2000, 88:264-265.
10. Ewens K.G., et al. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. PLoS ONE 2011, 6:e16390.
11. Florez J.C., et al. Diabetes Prevention Program Research Group (2006) TCF7L2 polymorphisms and progression to diabetes in the diabetes prevention program. N. Engl. J. Med. 2006, 355:241-250.
12. Franks S. Polycystic ovary syndrome. N. Engl. J. Med. 1995, 333:853-861.
13. Galluzzo A., Amato M.C., Giordano C. Insulin resistance and polycystic ovary syndrome. Nutr. Metab. Cardiovasc. Dis. 2008, 18:511-518.
14. González A., et al. CAPN10 alleles are associated with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 2002, 87:3971-3976.
15. Goodarzi M.O., et al. Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome. Fertil. Steril. 2011, 95:1736-1741.
16. Goodarzi M.O., Dumesic D.A., Chazenbalk G., Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat. Rev. Endocrinol. 2011, 7:219-231.
17. Grant S.F., et al. Variant of transcription factor 7-like 2 (TCF7L2) genes confers risk of type 2 diabetes. Nat. Genet. 2006, 38:320-323.
18. Helgason A., et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat. Genet. 2007, 39:218-225.
19. Holte J. Disturbances in insulin secretion and sensitivity in women with the polycystic ovary syndrome. Baillieres Clin. Endocrinol. Metab. 1996, 10:221-247.
20. Jansen E., et al. Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients. Mol. Endocrinol. 2004, 18:3050-3063.
21. Kenigsberg S., Bentov Y., Chalifa-Caspi V., Potashnik G., Ofir R., Birk O.S. Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients. Mol. Hum. Reprod. 2009, 15:89-103.
22. Kim J.J., et al. Polycystic ovary syndrome is not associated with polymorphisms of the TCF7L2, CDKAL1, HHEX, KCNJ11, FTO and SLC30A8 genes. Clin. Endocrinol. (Oxf.) 2012, 77:439-445.
23. Legro R.S., Kunselman A.R., Dodson W.C., Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J. Clin. Endocrinol. Metab. 1999, 84:165-169.
24. Márquez J.L., Pacheco A., Valdés P., Salazar L.A. Association between CAPN10 UCSNP-43 gene polymorphism and polycystic ovary syndrome in Chilean women. Clin. Chim. Acta 2008, 398:5-9.
25. Norman R.J., Dewailly D., Legro R.S., Hickey T.E. Polycystic ovary syndrome. Lancet 2007, 370:685-697.
26. Orio F., et al. The cardiovascular risk of young women with polycystic ovary syndrome: an observational, analytical, prospective case-control study. J. Clin. Endocrinol. Metab. 2004, 89:3696-3701.
27. Philibert P., et al. Molecular analysis of WNT4 gene in four adolescent girls with mullerian duct abnormality and hyperandrogenism (atypical Mayer-Rokitansky-Kuster-Hauser syndrome). Fertil. Steril. 2011, 95:2683-2686.
28. Roldán B., San Millán J.L., Escobar-Morreale H.F. Genetic basis of metabolic abnormalities in polycystic ovary syndrome: implications for therapy. Am. J. Pharmacogenomics 2004, 4:93-107.
29. Tang S.T., Wang C.J., Tang H.Q., Peng W.J., Wang Y.M., Zhang Q. Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with polycystic ovary syndrome: a meta-analysis. Mol. Biol. Rep. 2012, 39:9649-9660.
30. Teede H., Deeks A., Moran L. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med. 2010, 8:41.
31. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum. Reprod. 2004, 19:41-47.
32. Turki A., Al-Zaben G.S., Mtiraoui N., Marmmuoch H., Mahjoub T., Almawi W.Y. Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects. Gene 2013, 513:244-248.
33. Urbanek M. The genetics of the polycystic ovary syndrome. Nat. Clin. Pract. Endocrinol. Metab. 2007, 3:103-111.
34. Včelák J., et al. T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition. Physiol. Res. 2012, 61:229-240.
35. Venkatesan A.M., Dunaif A., Corbould A. Insulin resistance in polycystic ovary syndrome: progress and paradoxes. Recent Prog. Horm. Res. 2001, 56:295-308.
36. Wild R.A., et al. Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society. J. Clin. Endocrinol. Metab. 2010, 95:2038-2049.
37. Wojciechowski P., et al. Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis. Diabetologia 2012, 55:2636-2645.
38. Xu P., et al. Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome. J. Assist. Reprod. Genet. 2010, 27:23-28.
39. Xu X., et al. Family association study between INSR gene polymorphisms and PCOS in Han Chinese. Reprod. Biol. Endocrinol. 2011, 9:76.
40. Yalamanchi S.K., Sam S., Cardenas M.O., Holaday L.W., Urbanek M., Dunaif A. Association of fibrillin-3 and transcription factor-7-like 2 gene variants with metabolic phenotypes in PCOS. Obesity (Silver Spring) 2012, 20:1273-1278.
41. Yi F., Brubaker P.L., Jin T. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3-beta. J. Biol. Chem. 2005, 280:1457-1464.