The mortal strand hypothesis: Non-random chromosome inheritance and the biased segregation of damaged DNA

Seminars in Cell and Developmental Biology

Volumn 24, Issue 8-9, 2013, Pages 653-660

  Charville, Gregory W ^a   Rando, Thomas A ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Asymmetric cell division; Chromosomes; DNA damage; Immortal strands; Mortal strands; Sister chromatids; Stem cells

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; HISTONE H2A; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; ASYMMETRIC CELL DIVISION; CELL CYCLE ARREST; CELL FATE; CHROMOSOME SEGREGATION; DAUGHTER CELL; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA STRAND; DNA STRAND BREAKAGE; DNA TEMPLATE; DOUBLE STRANDED DNA BREAK; HUMAN; HYPOTHESIS; MORTAL STRAND HYPOTHESIS; MORTALITY; NONHUMAN; PHENOTYPE; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; QUALITY CONTROL; REVIEW; SENESCENCE; SEX CHROMOSOMAL INHERITANCE; SISTER CHROMATID;

EUKARYOTA;

ASYMMETRIC CELL DIVISION; CHROMOSOMES; DNA DAMAGE; IMMORTAL STRANDS; MORTAL STRANDS; SISTER CHROMATIDS; STEM CELLS;

ANIMALS; CHROMOSOME SEGREGATION; DNA; DNA DAMAGE; HUMANS; INHERITANCE PATTERNS; MODELS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84887613130     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2013.05.006     Document Type: Review

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