The majority of multipotent epidermal stem cells do not protect their genome by asymmetrical chromosome segregation

Stem Cells

Volumn 26, Issue 11, 2008, Pages 2964-2973

  Sotiropoulou, Panagiota A ^a   Candi, Aurélie ^a   Blanpain, Cédric ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Cancer; Cell division; Chromosome segregation; Stem cells

Indexed keywords

NUCLEOTIDE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIVISION; CHROMATIN; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DNA STRAND; EPIDERMIS; GENOME; HAIR FOLLICLE; HOMEOSTASIS; MORPHOGENESIS; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; SKIN;

EID: 56249107718     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2008-0634     Document Type: Article

References (35)

1. Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 2008;132:598-611.
2. Blanpain C, Fuchs E. Epidermal stem cells of the skin. Annu Rev Cell Dev Biol 2006;22:339-373.
3. Blanpain C, Lowry WE, Geoghegan A et al. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 2004;118:635-648.
4. Tumbar T, Guash G, Greco V et al. Defining the epithelial stem cell niche in skin. Science 2004;303:359-363.
5. Morris RJ, Liu Y, Marles L et al. Capturing and profiling adult hair follicle stem cells. Nat Biotechnol 2004;22:411-417.
6. Cairns J. Mutation selection and the natural history of cancer. Nature 1975;255:197-200.
7. Potten CS, Hume WJ, Cairns J. The segregation of DNA in epithelial stem cells. Cell 1978;15:899-906.
8. Potten CS, Owen G, Booth D. Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 2002;115:2381-2388.
9. Karpowicz P, Morshead C, Kam A et al. Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro. J Cell Biol 2005;170:721-732.
10. Smith GH. Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands. Development 2005;132:681-687.
11. Shinin V, Gayraud-Morel B, Gomes D et al. Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Nat Cell Biol 2006;8:677-687.
12. Cotsarelis G, Sun TT, Lavker RM. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 1990;61:1329-1337.
13. Braun KM, Niemann C, Jensen UB et al. Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development 2003;130:5241-5255.
14. Braun KM, Watt FM. Epidermal label-retaining cells: background and recent applications. J Investig Dermatol Symp Proc 2004;9:196-201.
15. Rando TA. The immortal strand hypothesis: segregation and reconstruction. Cell 2007;129:1239-1243.
16. Lansdorp PM. Immortal strands? Give me a break. Cell 2007;129:1244-1247.
17. Kiel MJ, He S, Ashkenazi R et al. Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature 2007;449:238-242.
18. Trempus CS, Morris RJ, Bortner CD et al. Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol 2003;120:501-511.
19. Horsley V, Alipantis AO, Polak L et al. NFATc1 balances quiescence and proliferation of skin stem cells. Cell 2008;132:299-310.
20. Nowak JA, Polak L, Pasolli HA et al. Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell 2008;3:33-43.
21. Kuroki T, Murakami Y. Random segregation of DNA strands in epidermal basal cells. Jpn J Cancer Res 1989;80:637-642.
22. Waghmare SK, Bansal R, Lee J et al. Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells. EMBO J 2008;27:1309-1320.
23. Wilson C, Cotsarelis G, Wei ZG et al. Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles. Differentiation 1994;55:127-136.
24. Brennand K, Huangfu D, Melton D. All beta Cells Contribute Equally to Islet Growth and Maintenance. PLoS Biol 2007;5:e163.
25. Blanpain C, Horsley V, Fuchs E. Epithelial stem cells: turning over new leaves. Cell 2007;128:445-458.
26. Qian H, Buza-Vidas N, Hyland CD et al. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell 2007;1:671-684.
27. Yoshihara H, Arai F, Hosokawa K et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 2007;1:685-697.
28. Ito M, Kizawa K, Hamada K et al. Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen. Differentiation 2004;72:548-557.
29. Lowry WE, Blanpain C, Nowak JA et al. Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev 2005;19:1596-1611.
30. Conboy MJ, Karasov AO, Rando TA. High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny. Plos Biol 2007;5:e102.
31. Shackleton M, Vaillant F, Simpson KJ et al. Generation of a functional mammary gland from a single stem cell. Nature 2006;439:84-88.
32. Stingl J, Eirew P, Ricketson L et al. Purification and unique properties of mammary epithelial stem cells. Nature 2006;439:993-997.
33. Barker N, van Es JH, Kuipers J et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007;449:1003-1007.
34. Morris RJ, Potten CS. Highly persistent label-retaining cells in the hair follicles of mice and their fate following induction of anagen. J Invest Dermatol 1999;112:470-475.
35. Armakolas A, Klar AJ. Cell type regulates selective segregation of mouse chromosome 7 DNA strands in mitosis. Science 2006;311:1146-1149.