Leptin receptor-deficient (knockout) medaka, Oryzias latipes, show chronical up-regulated levels of orexigenic neuropeptides, elevated food intake and stage specific effects on growth and fat allocation

General and Comparative Endocrinology

Volumn 195, Issue , 2014, Pages 9-20

  Chisada, Shin ichi ^a   Kurokawa, Tadahide ^b   Murashita, Koji ^a   Rønnestad, Ivar ^c   Taniguchi, Yoshihito ^d,f   Toyoda, Atsushi ^e,g   Sakaki, Yoshiyuki ^e,h   Takeda, Shunichi ^d   Yoshiura, Yasutoshi ^a,i  

^a FISHERIES RESEARCH AGENCY   (Japan)

^b FISHERIES RESEARCH AGENCY   (Japan)

^c UNIVERSITY OF BERGEN   (Norway)

^d KYOTO UNIVERSITY   (Japan)

^e RIKEN YOKOHAMA INSTITUTE   (Japan)

^f KEIO UNIVERSITY   (Japan)

^g NATIONAL INSTITUTE OF GENETICS   (Japan)

^h TOYOHASHI UNIVERSITY OF TECHNOLOGY   (Japan)

ⁱ JAPAN FISHERIES RESEARCH AND EDUCATION AGENCY   (Japan)

Author keywords

Deficiency; Hyperphagia; Leptin receptor; Medaka; Mutant; TILLING

Indexed keywords

AGOUTI RELATED PROTEIN; AMINO ACID; CYSTEINE; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; MUTANT PROTEIN; NEUROPEPTIDE; NEUROPEPTIDE YA; PROOPIOMELANOCORTIN; PROOPIOMELANOCORTIN 1; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL TISSUE; APPETITE; ARTICLE; BODY GROWTH; BODY SIZE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DIENCEPHALON; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE TARGETING; GROWTH RATE; HOMOZYGOTE; HORMONE BINDING; HYPERPHAGIA; INTRAABDOMINAL FAT; JUVENILE ANIMAL; LEPR GENE; LIPID STORAGE; LIVER; MUSCLE TISSUE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; ORYZIAS; PHENOTYPE; PLASMA; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; STOP CODON; UPREGULATION; ANIMAL; BODY WEIGHT; DRUG EFFECTS; EATING; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTATION; OBESITY; PATHOLOGY; PHYSIOLOGY; TRANSGENIC ANIMAL;

AGOUTI-RELATED PROTEIN; ANIMALS; ANIMALS, GENETICALLY MODIFIED; APPETITE; BODY WEIGHT; DIENCEPHALON; EATING; GENE KNOCKOUT TECHNIQUES; HYPERPHAGIA; INTRA-ABDOMINAL FAT; LEPTIN; MUTATION; NEUROPEPTIDES; OBESITY; ORYZIAS; RECEPTORS, LEPTIN; UP-REGULATION;

EID: 84887604341     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2013.10.008     Document Type: Article

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