Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast

Journal of Cell Science

Volumn 126, Issue 21, 2013, Pages 5052-5061

  Tay, Ye Dee ^a   Patel, Avinash ^a,b   Kaemena, Daniel F ^a,c   Hagan, Iain M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Analogue sensitive kinase; Cdc25; Mitosis; S. pombe; Wee1

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; CASEIN KINASE II; METHIONINE; ORB5 KINASE; PHENYLALANINE; PHOSPHOTRANSFERASE; PLO1 KINASE; PROTEIN TYROSINE PHOSPHATASE; SCHIZOSACCHAROMYCES POMBE PROTEIN; UNCLASSIFIED DRUG; WEE1 KINASE;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL SYNCHRONIZATION; CONTROLLED STUDY; DNA REPLICATION; ENZYME MODIFICATION; G2 PHASE CELL CYCLE CHECKPOINT; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE; SEQUENCE ALIGNMENT; TEMPERATURE SENSITIVE MUTANT; TEMPERATURE SENSITIVITY;

ANALOGUE-SENSITIVE KINASE; CDC25; MITOSIS; S. POMBE; WEE1;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; CASEIN KINASE II; CELL CYCLE PROTEINS; CONSERVED SEQUENCE; ENZYME INHIBITORS; METHIONINE; MITOSIS; MUTATION, MISSENSE; NUCLEAR PROTEINS; PHENYLALANINE; PHOSPHOPROTEIN PHOSPHATASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EID: 84887599503     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.135301     Document Type: Article

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