Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA)

Biochemistry

Volumn 52, Issue 45, 2013, Pages 8069-8078

  Dourado, Daniel F A R ^a,b,c,d   Fernandes, Pedro Alexandrino ^a   Ramos, Maria João ^a   Mannervik, Bengt ^b,c  

^a UNIVERSITY OF PORTO   (Portugal)

^b UPPSALA UNIVERSITY   (Sweden)

^c STOCKHOLM UNIVERSITY   (Sweden)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; ALKYLATING AGENTS; CHEMOTHERAPEUTIC AGENTS; CLINICAL EFFECTS; EXPERIMENTAL KINETICS; GLUTATHIONE TRANSFERASE; INTERMOLECULAR INTERACTIONS; NON SMALL CELL LUNG CANCER;

CHEMOTHERAPY; DISEASES; MUTAGENS;

PEPTIDES;

CANFOSFAMIDE; GLUTATHIONE TRANSFERASE P1; HYDROXYL GROUP; SULFONE;

ARTICLE; CATALYST; CHEMICAL STRUCTURE; DENSITY FUNCTIONAL THEORY; DRUG MECHANISM; ELIMINATION REACTION; ENZYME ACTIVE SITE; FORCE; KINETICS; MOLECULAR INTERACTION; PRIORITY JOURNAL;

GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; MOLECULAR STRUCTURE; PRODRUGS;

EID: 84887597240     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4005705     Document Type: Article

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