Retrovirus-mediated gene transfer of rat glutathione S-Transferase Yc confers in vitro resistance to alkylating agents in human leukemia cells and in clonogenic mouse hematopoietic progenitor cells

Human Gene Therapy

Volumn 7, Issue 7, 1996, Pages 831-840

  Létourneau, Sylvain ^b   Greenbaum, Mona ^b   Cournoyer, Denis ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; CHLORAMBUCIL; CHLORMETHINE; GLUTATHIONE TRANSFERASE; MELPHALAN; METHOTREXATE;

ANIMAL CELL; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG RESISTANCE; EXPRESSION VECTOR; FEMALE; GENE TRANSFER; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOUSE; NONHUMAN; RETROVIRUS;

EID: 0029867694     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.7-831     Document Type: Article

References (49)

1. BELMONT, J.W., MACGREGOR, G.R., WAGER-SMITH, K., FLETCHER, F.A., MOORE, K.A., HAWKINS, D., VILLALON, D., CHANG, S.M.W., and CASKEY, C.T. (1988). Expression of human adenosine deaminase in murine hematopoietic cells. Mol. Cell. Biol. 8, 5116-5125.
2. BERTINO, J.R. (1990). "Turning the tables" - Making normal marrow resistant to chemotherapy. J. Natl. Cancer Inst. 82, 1234-1235.
3. 6-alkylguanine DNA adducts in glioma-derived human cells resistant to cytotoxic. Carcinogenesis 7, 879-883.
4. BULLER, A.L., CLAPPER, M.L., and TEW, K.D. (1987). Glutathione-S-transferase in nitrogen mustard-resistant and sensitive cell lines. Mol. Pharmacol. 31, 575-578.
5. BUNTING, K.D., LINDAHL, R., and TOWNSEND, A.J. (1994). Oxazaphosphorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3 aldehyde dehydrogenase. J. Biol. Chem. 269, 23197-23203.
6. CHABNER, B.A., and MYERS, C.E. (1989). Clinical pharmacology of cancer chemotherapy. In Cancer: Principle and Practice of Oncology. V.T. DeVita, S. Hellman, and S.A. Rosenberg, eds. (J.B. Lippincott, Philadelphia) pp. 349-395.
7. COREY, C.A., DESILVA, A.D., HOLLAND, C.A., and WILLIAMS, D.A. (1990). Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells. Blood 75, 337-343.
8. COURNOYER, D., SCARPA, M., MITANI, K., MOORE, K.A., MARKOWITZ, D., BANK, A., BELMONT, J.W., and CASKEY, C.T. (1991). Gene transfer of adenosine deaminase into primitive human hematopoietic progenitor cells. Hum. Gene Ther. 2, 203-213.
9. DANIEL, V. (1993). Gluthatione S-transferases: gene structure and regulation of expression. Crit. Rev. Bioch. Mol. Biol. 28, 173-207.
10. 6-alkylguanine DNA alkyltransferase. Cancer Res. 49, 6044-6051.
11. ELLMAN, G.L. (1959). Tissue sulfhydral group. Arch. Biochem. Biophys. 82, 70-77.
12. EVANS, C.G., BODELL, W.J., TOKUDA, K., DOANE-SETZER, P., and SMITH, M.T. (1987). Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard. Cancer Res. 47, 2525-2530.
13. 6-methylguanine. Biochem. Pharmacol. 443, 1101-1107.
14. GREENBAUM, M., LÉTOURNEAU, S., ASSAR, H., SCHECTER, R.L., BATIST, G., and COURNOYER, D. (1994). Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers alkylating drug resistance in NIH 3T3 mouse fibroblasts. Cancer Res. 54, 4442-4447.
15. HABIG, W.H., PABST, M.J., and JAKOBY, W.B. (1974). Glutathione S-transferase: The first enzymic step in mercapturic acid formation. J. Biol. Chem. 249, 7130-7139.
16. HOANG, T., and MCCULLOCH, E.A. (1985). Production of leukemic blast growth factor by a human bladder carcinoma cell line. Blood 66, 748-751.
17. Human gene marker/therapy clinical protocols. (1994). Hum. Gene Ther. 5, 1537-1551.
18. Human gene marker/therapy clinical protocols. (1995). Hum. Gene Ther. 6, 1357-1360.
19. KELLER, G., PAIGE, C., GILBOA, E., and WAGNER, E.F. (1985). Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Nature 318, 149-154.
20. LEWIS, A.D., HICKSON, I.D., ROBSON, C.N., HARRIS, A.L., HAYES, J.D., GRIFFITHS, S.A., MANSON, M.M., HALL, A.E., MOSS, J.E., and WOLF, C.R. (1988). Amplification and increased expression of alpha class glutathione-S-transferase-encoding genes associated with resistance to nitrogen mustards. Proc. Natl. Acad. Sci. USA 85, 8511-8515.
21. LI, H., GYLLENSTEN, U.B., CUI, X., SAIKI, R.K., ERLICH, H.A., and ARNHEIM, N. (1988). Amplification and analysis of DNA sequences in single human sperm and diploid cells. Nature 335, 414-417.
22. LI, M.-X., BANERJE, D., ZHAO, S.-C., SCHWEITZER, B.I., MINEISHI, S., GILBOA, E., and BERTINO, J.R. (1994). Development of a retroviral construct containing a human mutated dihydrofolate reductase cDNA for hematopoietic stem cell transduction. Blood 83, 3403-3408.
23. LOWRY, O.H., Rosebrough, N.J., FARR, A.L., and RANDALL, R.J. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
24. LOZZIO, C.B., and LOZZIO, B.B. (1975). Human chronic myelogenous leukemia cell-line with Philadelphia chromosome. Blood 45, 321-334.
25. MAGLI, M.-C., DICK, J.E., HUSZAR, D., BERNSTEIN, A., and PHILLIPS, R.A. (1987). Modulation of gene expression in multiple hematopoietic cell lineages following retroviral vector gene transfer. Proc. Natl. Acad. Sci. USA 84, 789-793.
26. MANNERVICK, B. (1985). The isoenzymes of glutathione transferase. Adv. Enzymol. 57, 357-117.
27. MANNERVICK, B., and JENSSON, H. (1982). Binary combinations of four protein subunits with different catalytic specificities explain the relationship between six basic glutathione s-transferases in rat liver cytosol. J. Biol. Chem. 257, 9909-9912.
28. MARKOWITZ, D., GOFF, S., and BANK, A. (1988). Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167, 400-406.
29. MCLACHLIN, J.R., EGLITIS, M.A., UEDA, K., KANTOFF, P.W., ANDERSON, F.A., and GOTTESMAN, M.M. (1990). Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursors cells with the use of retroviral gene transfer. J. Natl. Cancer Inst. 82, 1260-1263.
30. MICKISCH, G.H., AKSENTIJEVISH, I., SCHOENLEIN, P.V., GOLDSTEIN, L.J., GALSKI, H., STAHLE, C., SACHS, D.H., PATAN, I., and GOTTESMAN, M.M. (1992). Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice. Blood 79, 1087-1093.
31. MURPHY, W.H., URNOVITZ, H.B., MARYANSKI, J.L., and ABRAMS, G.D. (1978). Characterization of transplantable myelomonocytic leukemia WEHI-3B in syngeneic BALB/C mice. Proc. Soc. Exp. Biol. Med. 157, 556-564.
32. NAKAGAWA, K., SAIJO, N., TSUCHIDA, S., SAKAI, M., TSUNOKAWA, Y., YOKOTA, J., MURAMATSU, M., SATO, K., TERADA, M., and TEW, K.D. (1990). Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines. J. Biol. Chem. 265, 4296-4301.
33. PAGLIA, D.E., and VALENTINE, W.N. (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione-peroxidase. J. Lab. Clin. Med. 70, 158-169.
34. PETERS, W.P. (1985). The rationale for high-dose chemotherapy with autologous bone marrow support in treating breast cancer. In: The First International Symposium on ABMT. K. Dicke, G. Spitzer, and A. Zander, eds. (University of Texas M.D. Anderson Hospital and Tumor Institute), pp. 189-195.
35. PODDA, S., WARD, M., HIMELSTEIN, A., RICHARDSON, C., DE LA FLOR-WEISS, E., SMITH, L., GOTTESMAN, M., PASTAN, I., and BANK, A. (1992). Transfer and expression of the human multiple drug resistance gene into live mice. Proc. Natl. Acad. Sci. USA 89, 9676-9680.
36. POWIS, G., and PROUGH, R.A. (1987). Metabolism and Action of Anti-Cancer Drugs. (Taylor and Francis, London).
37. PUCHALSKI, R.B., and FAHL, W.E., (1990). Expression of recombinant glutathione S-transferase pi, Ya or Ybl confers resistance to alkylating agents. Proc. Natl. Acad. Sci. USA 87, 2443-2447.
38. ROBSON, C.N., LEWIS, A.D., WOLF, C.R., HAYES, J.D., HALL, A., PROCTOR, S.J., HARRIS, A.L., and HICKSON, I.D. (1987). Reduced levels of drug-induced DNA cross linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione-S-transferase activity. Cancer Res. 47, 6022-6027.
39. SCHECTER, R.L., ALAOUI-JAMALI, M.A., WOO, A., FAHL, W.E., and BATIST, G. (1993). Expression of rat glutathione S-transferase Yc complementary DNA in rat mammary carcinoma cells: impact upon alkylator-induced toxicity. Cancer Res. 53, 4900-4906.
40. SCHECTER, R.L., COURNOYER, D., and BATIST, G. (1994). Glutathione S-transferase expression in mammary tumors and bone marrow cells. Cell. Pharmacol. 1, 153-157.
41. SHINNICK, T.M., LERNER, R.A., and SUTCLIFFE, J.G. (1981). Nucleotide sequence of Moloney murine leukemia virus. Nature 293, 543-548.
42. SORRENTINO, B.P., BRANDT, S.J., BODINE, D., GOTTESMAN, M., PASTAN, I., CLINE, A., and NIENHUIS, A.W. (1992). Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDRI. Science 257, 99-103.
43. SREERAMA, L., and SLADEK, N.E. (1993). Overexpression of polycyclic aromatic hydrocarbon-mediated induction of an apparently novel class 3 aldehyde dehydrogenase in human breast adenocarcinoma cells and its relationship to oxazaphosphorine-specific acquired resistance. Adv. Exp. Med. Biol. 328, 99-113.
44. TELAKOWSKI-HOPKINS, C.A., RODKEY, J.A., BENNETT, C.D., LU, A.Y., and PICKETT, C.B. (1985). Rat liver glutathione S-transferases. Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid-sequence of a Yc subunit. J. Biol. Chem. 260, 5820-5825.
45. TEW, K.D. (1994). Gluathione-associated enzymes in anticancer drug resistance. Cancer Res. 54, 4313-4320.
46. TORMEY, D., KLINE, J., KALISH-BLACK, D., LOVE, R., and CARBONE, P. (1984). Aggressive systemic therapy for metastatic breast cancer. In Current Controversies in Breast Cancer. F. Ames, G. Blumenschein, and E. Montague, eds. (University Texas Press, Houston) pp. 273-282.
47. WILLIAMS, D.A., HSIEH, K., DESILVA A., and MULLIGAN, R.C. (1987). Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexare-resistant bone marrow. J. Exp. Med. 166, 210-218.
48. WOLF, C.R., HAYWARD, I.P., LAURIE, S.S., BUCLON, K., MCINTYRE, M.A., ADAMS, D.J., LEWIS, A.D., SCOTT, A.R., and SMYTH, J.F. (1987). Cellular heterogeneity and drug resistance in two ovarian adenocarcinoma cell lines derived from a single patient. Int. J. Cancer. 39, 695-702.
49. YOSHIDA, A., DAVE, V., HAN, H., and SCANLON, K.J. (1993). Enhanced transcription of the cytosolic ALDH gene in cyclophosphamide resistant human carcinoma cells. Adv. Exp. Med. Biol. 328, 63-72.