Mechanism of formation of the internal aldimine in pyridoxal 5′-phosphate-dependent enzymes

Journal of the American Chemical Society

Volumn 133, Issue 39, 2011, Pages 15496-15505

  Oliveira, Eduardo F ^a   Cerqueira, Nuno M F S A ^a   Fernandes, Pedro A ^a   Ramos, Maria J ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; B3LYP/6-31G; FINAL ENERGY; MECHANISM OF FORMATION; MODEL-BASED OPC; NUCLEOPHILIC ATTACK; ORNITHINE DECARBOXYLASE; OVERALL REACTIONS; RATE-LIMITING STEPS; REACTION MECHANISM;

AMINO ACIDS; CRYSTAL ATOMIC STRUCTURE; DEHYDRATION; DEWATERING;

ENZYMES;

AMINE; CYSTEINE; HYDROGEN; IMINE; INTERNAL ALDIMINE; LYSINE; METHANOLAMINE; ORNITHINE DECARBOXYLASE; PYRIDOXAL 5 PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME REACTIVATION; HUMAN; METHODOLOGY; ONIOM METHODOLOGY; REACTION ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINES; HUMANS; IMINES; LYSINE; MODELS, MOLECULAR; ORNITHINE DECARBOXYLASE; PROTEIN STRUCTURE, QUATERNARY; VITAMIN B 6; WATER;

EID: 80053318335     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja204229m     Document Type: Article

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