Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α4β7

Journal of Cell Science

Volumn 126, Issue 21, 2013, Pages 5030-5041

  Zhang, Kun ^a   Pan, YouDong ^a   Qi, JunPeng ^a   Yue, Jiao ^a   Zhang, MingBo ^b,c   Xu, ChenQi ^a   Li, GuoHui ^b   Chen, JianFeng ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^c LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Disulfide restriction; Integrin clustering; Ligand independent signaling

Indexed keywords

ALPHA4BETA7 INTEGRIN; DISULFIDE; DITHIOTHREITOL; INTEGRIN; MANGANESE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL DISRUPTION; CELL MEMBRANE; CELL SPREADING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; HUMAN; HUMAN CELL; IN VIVO STUDY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SHEAR STRESS; SIGNAL TRANSDUCTION;

DISULFIDE-RESTRICTION; INTEGRIN CLUSTERING; LIGAND-INDEPENDENT SIGNALING;

AMINO ACID SEQUENCE; DISULFIDES; HUMANS; INTEGRIN ALPHA4; INTEGRIN BETA CHAINS; LIGANDS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EID: 84887582496     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.134528     Document Type: Article

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