Unique disulfide bonds in epidermal growth factor (EGF) domains of β3 affect structure and function of αIIbβ3 and αvβ3 integrins in different manner

Journal of Biological Chemistry

Volumn 287, Issue 12, 2012, Pages 8879-8891

  Mor Cohen, Ronit ^a   Rosenberg, Nurit ^a   Einav, Yulia ^b   Zelzion, Ehud ^b   Landau, Meytal ^a   Mansour, Wissam ^a   Averbukh, Yulia ^a   Seligsohn, Uri ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b HOLON INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CONSTITUTIVELY ACTIVES; CYSTEINE SUBSTITUTIONS; DISULFIDE BONDS; DITHIOTHREITOL; EPIDERMAL GROWTH FACTORS; HAMSTER KIDNEYS; INTEGRINS; SURFACE EXPRESSION;

AMINO ACIDS; CHEMICAL ACTIVATION; FLOW CYTOMETRY; GLYCOPROTEINS; MOLECULAR DYNAMICS;

COVALENT BONDS;

ALPHA2BETA3 INTEGRIN; CYSTEINE; EPIDERMAL GROWTH FACTOR; FIBRINOGEN; INTEGRIN; SERINE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISULFIDE BOND; ENZYME BINDING; FLOW CYTOMETRY; HUMAN; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CRICETINAE; DISULFIDES; EPIDERMAL GROWTH FACTOR; HUMANS; INTEGRIN ALPHAVBETA3; MOLECULAR SEQUENCE DATA; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

CRICETINAE;

EID: 84858606733     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.311043     Document Type: Article

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