An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties

Peptides

Volumn 50, Issue , 2013, Pages 153-159

  Mechkarska, Milena ^a   Prajeep, Manju ^a   Radosavljevic, Gordana D ^b   Jovanovic, Ivan P ^b   Baloushi, Amna Al ^a   Sonnevend, Agnes ^a   Lukic, Miodrag L ^b   Conlon, J Michael ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b UNIVERSITY OF KRAGUJEVAC   (Serbia)

Author keywords

Antimicrobial peptide; Carbapenem resistant Enterobacteriaceae; Cytokine; Hymenochirin 1B; MRSA; Structure activity

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPHOTERICIN B; AMPICILLIN; ANTIINFECTIVE AGENT; CARBAPENEM; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; COLISTIN; HYMENOCHIRIN 1B; INTERLEUKIN 10; INTERLEUKIN 4; LYSINE; TIGECYCLINE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ALPHA HELIX; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CANDIDA ALBICANS; CITROBACTER FREUNDII; CONTROLLED STUDY; DRUG POTENCY; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; HOST RESISTANCE; HUMAN; HUMAN CELL; HYDROPHILICITY; IMMUNOMODULATION; KLEBSIELLA PNEUMONIAE; LC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEUS MIRABILIS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STENOTROPHOMONAS MALTOPHILIA; STRUCTURE ACTIVITY RELATION;

ACINETOBACTER BAUMANNII; CITROBACTER FREUNDII; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE; ESCHERICHIA COLI; HYMENOCHIRUS BOETTGERI; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NEGIBACTERIA; PIPIDAE; POSIBACTERIA; STENOTROPHOMONAS MALTOPHILIA; XENOPUS (GENUS);

ANTIMICROBIAL PEPTIDE; CARBAPENEM-RESISTANT ENTEROBACTERIACEAE; CYTOKINE; HYMENOCHIRIN-1B; MRSA; STRUCTURE-ACTIVITY;

AMINO ACID SEQUENCE; AMPHIBIAN PROTEINS; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELLS, CULTURED; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-10; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PIPIDAE; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84887581286     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2013.10.015     Document Type: Article

References (43)

1. P.F. Almeida, and A. Pokorny Mechanisms of antimicrobial, cytolytic, and cell-penetrating peptides: from kinetics to thermodynamics Biochemistry 48 2009 8083 8093
2. R. Bessalle, H. Haas, A. Goria, I. Shalit, and M. Fridkin Augmentation of the antibacterial activity of magainin by positive-charge chain extension Antimicrob Agents Chemother 36 1992 313 317
3. Y. Chen, M.T. Guarnieri, A.I. Vasil, M.L. Vasil, C.T. Mant, and R.S. Hodges Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides Antimicrob Agents Chemother 51 2007 1398 1406
4. Y. Chen, C.T. Mant, S.W. Farmer, R.E. Hancock, M.L. Vasil, and R.S. Hodges Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index J Biol Chem 280 2005 12316 12329
5. Clinical Laboratory and Standards Institute Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically approved standard M07-A8 2008 CLSI Wayne, PA
6. Clinical Laboratory and Standards Institute Reference method for broth dilution antifungal susceptibility testing of yeast approved standard M27-A3 2008 CLS1 Wayne, PA
7. J.M. Conlon Structural diversity and species distribution of host-defense peptides in frog-skin secretions Cell Mol Life Sci 68 2011 2303 2315
8. J.M. Conlon The potential of frog skin antimicrobial peptides for development into therapeutically valuable anti-infective agents K. Rajasekaran, J.W. Cary, J. Jaynes, E. Montesinos, Small wonders: peptides for disease control 2012 American Chemical Society Symposium Series Washington DC 47 60
9. J.M. Conlon, E. Ahmed, and E. Condamine Antimicrobial properties of brevinin-2-related peptide and its analogs: efficacy against multi-drug-resistant Acinetobacter baumannii Chem Biol Drug Des 74 2009 488 493
10. J.M. Conlon, M. Mechkarska, J.M. Pantic, M.L. Lukic, L. Coquet, and J. Leprince An immunomodulatory peptide related to frenatin 2 from skin secretions of the Tyrrhenian painted frog Discoglossus sardus (Alytidae) Peptides 40 2013 65 71
11. J.M. Conlon, and A. Sonnevend Antimicrobial peptides in frog skin secretions Methods Mol Biol 618 2010 3 14
12. A. Eley, M. Ibrahim, S.E. Kurdi, and J.M. Conlon Activities of the frog skin peptide, ascaphin-8 and its lysine-substituted analogs against clinical isolates of extended-spectrum beta-lactamase (ESBL) producing bacteria Peptides 29 2008 25 30
13. H. Giamarellou, and G. Poulakou Multidrug-resistant Gram-negative infections: what are the treatment options? Drugs 69 2009 1879 1901
14. A. Giangaspero, L. Sandri, and A. Tossi Amphipathic alpha helical antimicrobial peptides Eur J Biochem 268 2001 5589 5600
15. L.M. Gottler, and A. Ramamoorthy Structure, membrane orientation, mechanism, and function of pexiganan - a highly potent antimicrobial peptide designed from magainin Biochim Biophys Acta 1788 2009 1680 1686
16. Y. Huang, J. Huang, and Y. Chen Alpha-helical cationic antimicrobial peptides: relationships of structure and function Protein Cell 1 2010 143 152
17. P.A. Jumaa, A. Sonnevend, T. Pàl, M. El Hag, R. Amith, and O. Trad The molecular epidemiology of Stenotrophomonas maltophilia bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000-2004 Ann Clin Microbiol Antimicrob 5 2006 32
18. A.U. Khan, and P. Nordmann NDM-1-producing Enterobacter cloacae and Klebsiella pneumoniae from diabetic foot ulcers in India J Med Microbiol 3 2012 454 456
19. J. Kindrachuk, and S. Napper Structure-activity relationships of multifunctional host defence peptides Mini Rev Med Chem 10 2010 596 614
20. A. Kotsaki, and E.J. Giamarellos-Bourboulis Emerging drugs for the treatment of sepsis Expert Opin Emerg Drugs 17 2012 379 391
21. D.M. Livermore Has the era of untreatable infections arrived? J Antimicrob Chemother 64 2009 i29 i36
22. W.L. Maloy, and U.P. Kari Structure-activity studies on magainins and other host defense peptides Biopolymers 37 1995 105 122
23. M. Mechkarska, M. Prajeep, L. Coquet, J. Leprince, T. Jouenne, and H. Vaudry The hymenochirins: a family of antimicrobial peptides from the Congo dwarf clawed frog Hymenochirus boettgeri (Pipidae) Peptides 35 2012 269 275
24. V. Muñoz, and L. Serrano Elucidating the folding problem of helical peptides using empirical parameters Nat Struct Biol 1 1994 399 409
25. F. Niyonsaba, L. Madera, N. Afacan, K. Okumura, H. Ogawa, and R.E. Hancock The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions J Leukoc Biol 94 2013 159 170
26. P. Nordmann, Couard, D. Sansot, and L. Poirel Emergence of an autochthonous and community-Acquired NDM-1-Producing Klebsiella pneumoniae in Europe Clin Infect Dis 54 2012 150 151
27. P. Nordmann, L. Dortet, and L. Poirel Carbapenem resistance in Enterobacteriaceae: here is the storm Trends Mol Med 18 2012 263 272
28. P. Nordmann, T. Naas, and L. Poirel Global spread of carbapenemase- producing Enterobacteriaceae Emerg Infect Dis 17 2011 1791 1798
29. T. Pál, A. Sonnevend, S. Galadari, and J.M. Conlon Design of potent, non-toxic antimicrobial agents based upon the structure of the frog skin peptide, pseudin-2 Regul Pept 129 2005 85 91
30. S. Popovic, E. Urbán, M. Lukic, and J.M. Conlon Peptides with antimicrobial and anti-inflammatory activities that have therapeutic potential for treatment of Acne vulgaris Peptides 34 2012 275 282
31. M. Schiffer, and A.B. Edmundson Use of helical wheels to represent the structures of proteins and to identify segments with helical potential Biophys J 7 1967 121 135
32. B.W. Senior Investigation of the types and characteristics of the proteolytic enzymes formed by diverse strains of Proteus species J Med Microbiol 48 1999 623 628
33. A. Sonnevend, A. Al Baloushi, A. Ghazawi, R. Hashmey, S. Girgis, and M.B. Hamadeh Emergence and spread of NDM-1 producer Enterobacteriaceae with contribution of IncX3 plasmids in the United Arab Emirates J Med Microbiol 62 2013 1044 1050
34. Á. Sonnevend, I. Blair, M. Alkaabi, P. Jumaa, M. Al Haj, and A. Ghazawi Change in meticillin-resistant Staphylococcus aureus clones at a tertiary care hospital in the United Arab Emirates over a 5-year period J Clin Pathol 65 2012 178 182
35. M. Sowmiya, J. Malathi, and H.N. Madhavan Screening of ocular Enterobacteriaceae isolates for presence of chromosomal blaNDM-1 and ESBL genes: a 2-year study at a tertiary eye care center Invest Ophthalmol Vis Sci 53 2012 5251 5257
36. M. Stark, L.P. Liu, and C.M. Deber Cationic hydrophobic peptides with antimicrobial activity Antimicrob Agents Chemother 46 2002 3585 3590
37. H. Tomioka, K. Sato, W.W. Maw, and H. Saito The role of tumor necrosis factor, interferon-gamma, transforming growth factor-beta, and nitric oxide in the expression of immunosuppressive functions of splenic macrophages induced by Mycobacterium avium complex infection J Leukoc Biol 58 1995 704 712
38. T.R. Walsh, M. Toleman, L. Poirel, and P. Nordmann Metallo-β- lactamases: the quiet before the storm Clin Microbiol Rev 18 2005 306 325
39. T.R. Walsh, J. Weeks, D.M. Livermore, and M.A. Toleman Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study Lancet Infect Dis 11 2011 355 362
40. P. Wang, Y.H. Nan, S.T. Yang, S.W. Kang, Y. Kim, I.S. Park, K.S. Hahm, and S.Y. Shin Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich alpha-helical model antimicrobial peptide and its diastereomeric peptides Peptides 31 2010 1251 1261
41. A.T. Yeung, S.L. Gellatly, and R.E. Hancock Multifunctional cationic host defence peptides and their clinical applications Cell Mol Life Sci 68 2011 2161 2176
42. M. Zaiou Multifunctional antimicrobial peptides: therapeutic targets in several human diseases J Mol Med 85 2007 317 329
43. W. Ziehbur, V. Krimmer, S. Rachid, I. Lössner, F. Götz, and J. Hacker A novel mechanism of phase variation of virulence in Staphylococcus epidermidis: evidence for control of the polysaccharide intercellular adhesion synthesis by alternating insertion and excision of the insertion sequence element IS256 Mol Microbiol 32 1999 345 356