Induction of apoptosis in human hepatoma SMMC-7721 cells using 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone, a chalcone from buds of Cleistocalyx operculatus

Food Science and Biotechnology

Volumn 22, Issue 5, 2013, Pages 1-7

  Ye, Chun Lin ^a   Liu, Xuan Gan ^a   Huang, Qi ^a   Zhao, Xian Liang ^a  

^a ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

apoptosis; caspase; Cleistocalyx operculatus; flavonoid; mitochondria

Indexed keywords

CASPASES; CLEISTOCALYX OPERCULATUS; FLAVONOID; FLUORESCENCE INTENSITIES; MITOCHONDRIAL MEMBRANE POTENTIAL; MORPHOLOGICAL CHANGES; POTENTIAL ANTICANCER AGENTS; SIGNAL TRANSDUCTION PATHWAYS;

MITOCHONDRIA; SIGNAL TRANSDUCTION;

CELL DEATH;

EID: 84887556813     PISSN: 12267708     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10068-013-0232-4     Document Type: Article

References (37)

1. Park HS, Park KI, Lee DH, Kang SR, Nagappan A, Kim JA, Lee WS, Shin SC, Hah YS, Kim GS. Polyphenolic extract isolated from Korean Lonicera japonica Thunb. induce G2/M cell cycle arrest and apoptosis in HepG2 Cells: Involvements of PI3K/Akt and MAPKs. Food Chem. Toxicol. 50: 2407-2416 (2012).
2. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod. 66: 1022-1037 (2003).
3. Johnson JJ, Syed DN, Heren CR, Suh Y, Adhami VM, Mukhtar H. Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5-AMP-activated protein kinase (AMPK) pathway. Pharm. Res. 25: 2125-2134 (2008).
4. Cha JD, Kim YH, Kim JY. Essential oil and 1, 8-cineole from Artemisia lavandulaefolia induces apoptosis in KB cells via mitochondrial stress and caspase activation. Food Sci. Biotechnol. 19: 185-191 (2010).
5. Park KW, Ye SH, Kim YJ, Jung SR, Bang MH, Lee HW, Park KM. In vitro and in vivo anti-tumor effects of oiental herbal mixtures. Food Sci. Biotechnol. 19: 1019-1027 (2010).
6. Yoon H, Lee CY. Effect of selected phytochemicals on cell proliferation in A549 lung cancer cells. Food Sci. Biotechnol. 19: 1063-1068 (2010).
7. Woo AYH, Waye MMY, Kwan HS, Chan MCY, Chau CF, Cheng CHK. Inhibition of ATPases by Cleistocalyx operculatus: A possible mechanism for the cardiotonic actions of the herb. Vasc. Pharmacol. 38: 163-168 (2002).
8. Mai TT, Chuyen NV. Anti-hyperglycemic activity of an aqueous extract from flower buds of Cleistocalyx operculatus (Roxb.) Merr and Perry. Biosci. Biotech. Bioch. 71: 69-76 (2007).
9. Ye CL, Lu YH, Wei DZ. Flavonoids from Cleistocalyx operculatus. Phytochemistry 65: 445-447 (2004).
10. Anto RJ, Sukumara K, Kuttan G, Rao MNA, Subbaraju V, Kuttan R. Anticancer and antioxidant of synthetic chalcones and related compounds. Cancer Lett. 97: 33-37 (1995).
11. Parmar VS, Sharma NK, Husain M, Watterson AC, Kumar J, Samuelson LA, Cholli AL, Prasad AK, Kumar A, Malhotra S, Kumar N, Jha A, Singh I, Himanshu, Vats A, Shakil NA, Trikha S, Mukhejee S, Sharma SK, Singh SK, Kumar A, Jha HN, Olsen CE, Stove CP, Bracke ME, Mareef MM. Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds. Bioorgan. Med. Chem. 11: 913-929 (2003).
12. Le Bail JC, Pouget C, Fagnere C, Basly JP, Chulia AJ, Habrioux G. Chalcones are potent inhibitors of aromatase and 17β-hydroxysteroid dehydrogenase activities. Life Sci. 68: 751-761 (2001).
13. Saydam G, Aydin H, Sahin F, Kucukoglu O, Ericiyas E, Terzioglu E, Buyukkececi F, Omay SB. Cytotoxic and inhibitory effects of 4′, 4′-dihydroxy chalcone (RVC-588) on proliferation of human leukemic HL-60 cells. Leukemia Res. 27: 57-64 (2003).
14. Nam N, Kim Y, You Y, Hong D, Kim H, Ahn B. Cytotoxic 2′, 4′-dihydroxychalcones with unexpected antiangiogenic activity. Eur. J. Med. Chem. 38: 179-187 (2003).
15. Iwashita K, Kobori M, Yamaki K, Tsushida T. Falvonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci. Biotech. Bioch. 64: 1813-1820 (2000).
16. Kobori M, Iwashita K, Shinmoto H, Tsushida T. Phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL-60 human leukemia cells. Biosci. Biotech. Bioch. 63: 719-725 (1999).
17. Li CC, Yang CZ, Li XM, Zhao XM, Zou Y, Fan L, Zhou L, Liu JC, Niu YC. Hydroxysafflor yellow A induces apoptosis in activated hepatic stellate cells through ERK1/2 pathway in vitro. Eur. J. Pharm. Sci. 46: 397-404 (2012).
18. Ye CL, Liu JW, Wei DZ, Lu YH, Qian F. In vitro anti-tumor activity of 2′, 4′-dihydroxy-6′-methoxy-3′, 5′-dimethylchalcone against six established human cancer cell lines. Pharmacol. Res. 50: 505-510 (2004).
19. Ye CL, Liu JW, Wei DZ, Lu YH, Qian F. In vivo antitumor activity by 2′, 4′-dihydroxy-6′-methoxy-3′, 5′-dimethylchalcone in a solid human carcinoma xenograft model. Cancer Chemother. Pharmacol. 55: 447-452 (2005).
20. Ye CL, Lu YH, Li XD, Wei DZ. HPLC analysis of bioactive chalcone and triterpene in the buds of Cleistocalyx operculatus. S. Afr. J. Bot. 71: 312-315 (2005).
21. Ye M, Liu JK, Lu ZX, Zhao Y, Liu SF, Li LL, Tan M, Weng XX, Li W, Cao Y. Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro. FEBS Lett. 579: 3437-3443 (2005).
22. Wang ZH, Tang XL, Zhang YL, Qi RZ, Li ZW, Zhang KM, Liu ZW, Yang XY. Lobaplatin induces apoptosis and arrests cell cycle progression in human cholangiocarcinoma cell line RBE. Biomed. Pharmacother. 66: 161-166 (2012).
23. Cao J, Liu Y, Jia L, Zhou HM, Kong Y, Yang G, Jiang LP, Li QJ, Zhong LF. Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells. Free Radic. Biol. Med. 43: 968-975 (2007).
24. Xu HL, Yu XF, Qu SC, Qu XR, Jiang YF, Sui DY. Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen speciesdependent mechanism. Food Chem. Toxicol. 50: 590-596 (2012).
25. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254 (1976).
26. Ji YB, Qu ZY, Zou X. Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Exp. Toxicol. Pathol. 63: 69-78 (2011).
27. Ly JD, Grubb DR, Lawen A. The mitochondrial membrane potential [deltapsi (m)] in apoptosis; An update. Apoptosis 8: 115-128 (2003).
28. Zhou PH, Liu SQ, Peng H. The effect of hyaluronic acid on IL-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. J. Orthop. Res. 26: 1643-1648 (2008).
29. Herr I, Debatin KM. Cellular stress response and apoptosis in cancer therapy. Blood 98: 2603-2614 (2001).
30. Liu HB, Xiao YL, Xiong CM, Wei AH, Ruan JL. Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation. Eur. J. Pharmacol. 654: 209-216 (2011).
31. Stennicke HR, Salvesen GS. Properties of the caspases, Biochim. Biophys. Acta 1387: 17-31 (1998).
32. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43 (1995).
33. Patel T, Gores GJ, Kaufmann SH. The role of proteases during apoptosis. FASEB J. 10: 587-597 (1996).
34. Olsson AR, Lindgren H, Pero RW, Leanderson T. Mechanism of action for N-substituted benzamide-induced apoptosis. Brit. J. Cancer 86: 971-978 (2002).
35. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251 (1993).
36. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J. Cell Mol. Med. 7: 249-257 (2003).
37. Oltral ZN, Millman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog Bax that accelerates programmed cell death. Cell 74: 609-619 (1993).