Inhibition of phosphodiesterase 4 modulates cytokine induction from toll like receptor activated, but not rhinovirus infected, primary human airway smooth muscle

Respiratory Research

Volumn 14, Issue 1, 2013, Pages

  Van Ly, David ^a,b   De Pedro, Monique ^a,b   James, Peter ^a,b   Morgan, Lucy ^c   Black, Judith L ^a,b   Burgess, Janette K ^a,b   Oliver, Brian G G ^a,b  

^a WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c Department of Microbiology and Infectious Diseases   (Australia)

Author keywords

Airway smooth muscle; COPD; Formoterol; Imiquimod; Phosphodiesterase 4; Piclamilast; Poly I: C; Rhinovirus

Indexed keywords

CYCLIC AMP; CYTOKINE; FORMOTEROL; IMIQUIMOD; INTERLEUKIN 28B; INTERLEUKIN 29; INTERLEUKIN 6; INTERLEUKIN 8; PHOSPHODIESTERASE IV; PICLAMILAST; POLYINOSINIC POLYCYTIDYLIC ACID; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; AMINOQUINOLINE DERIVATIVE; BENZAMIDE DERIVATIVE; PHOSPHODIESTERASE IV INHIBITOR; PYRIDINE DERIVATIVE; TLR3 PROTEIN, HUMAN; TLR7 PROTEIN, HUMAN; TLR8 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 3;

ADOLESCENT; ADULT; AGED; AIRWAY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; MALE; RHINOVIRUS; SMOOTH MUSCLE FIBER; VIRUS REPLICATION; BRONCHUS; CELL CULTURE; COMORBIDITY; DRUG EFFECT; DRUG POTENTIATION; EPITHELIUM CELL; IN VITRO STUDY; METABOLISM; MIDDLE AGED; PATHOLOGY; PICORNAVIRUS INFECTION; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AMINOQUINOLINES; BENZAMIDES; BRONCHI; CELLS, CULTURED; COMORBIDITY; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYTOKINES; EPITHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; PHOSPHODIESTERASE 4 INHIBITORS; PICORNAVIRIDAE INFECTIONS; POLY I-C; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PYRIDINES; RHINOVIRUS; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TOLL-LIKE RECEPTORS; YOUNG ADULT;

EID: 84887552743     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-14-127     Document Type: Article

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