Are professional soccer players at higher risk for ALS

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Volumn 14, Issue 7-8, 2013, Pages 501-506

  Beghi, Ettore ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Amyotrophic lateral sclerosis; Motor neuron disease; Soccer; Sport

Indexed keywords

PESTICIDE;

AMYOTROPHIC LATERAL SCLEROSIS; ATHLETE; DIET SUPPLEMENTATION; ENVIRONMENTAL FACTOR; EXERCISE; HEAD INJURY; HUMAN; INCIDENCE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SOCCER; SUBSTANCE ABUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CRANIOCEREBRAL TRAUMA; DIETARY SUPPLEMENTS; ENVIRONMENTAL EXPOSURE; EXERCISE; HUMANS; MALE; PESTICIDES; RISK FACTORS; SOCCER;

EID: 84887494939     PISSN: 21678421     EISSN: 21679223     Source Type: Journal    
DOI: 10.3109/21678421.2013.809764     Document Type: Review

References (63)

1. Beghi E, Chiò A, Ferrarese C. The sinister side of Italian soccer (Refl ection & Reaction). Lancet Neurol. 2003; 2:656-7.
2. Chiò A, Benzi G, Dossena M, Mutani R, Mora G. S everely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain. 2005; 128:472-6.
3. Belli S, Vanacore N. P roportionate mortality of Italian soccer players: is amyotrophic lateral sclerosis an occupational disease Eur J Epidemiol. 2005; 20:237-42.
4. Taioli E. A ll causes of mortality in male professional soccer players. Eur J Publ Health. 2007; 17:600-4.
5. Armon C. S ports and trauma in amyotrophic lateral sclerosis revisited. J Neurol Sci. 2007; 262:45-53.
6. Armon C. A myotrophic lateral sclerosis and soccer: a different epidemiological approach strengthens the previous fi ndings. J Neurol Sci. 2008; 269:188-90.
7. Kurland L T, Radhakrishnan K, Smith G E, Armon C, Nemetz PN. Mechanical trauma as a risk factor in classic amyotrophic lateral sclerosis: lack of epidemiological evidence. J Neurol Sci. 1992; 113:133-43.
8. Armon C. A n evidence based medicine approach to the evaluation of the role of exogenous risk factors in sporadic amyotrophic lateral sclerosis. Neuroepidemiology. 2003; 22:217-28.
9. Pupillo E, Messina P, Logroscino G, Zoccolella S, Chiò A, Calvo A, et al; EURALS Consortium. Trauma and amyotrophic lateral sclerosis: a case-control study from a population based registry. Eur J Neurol. 2012; 19:1509-17.
10. Chen H, Richard M, Sandler DP, Umbach DM, Kamel F. Head injury and amyotrophic lateral sclerosis. Am J Epidemiol. 2007; 166:810-6.
11. Beghi E, Millul A, Micheli A, Vitelli E, Logroscino G; SLALOM Group. Incidence of ALS in Lombardy, Italy. Neurology. 2007; 68:141-5.
12. McKee A, Cantu R, Nowinski C, Hedley-Whyte ET, Gavett BE, Budson AE, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repeated head injury. J Neuropathol Exp Neurol. 2009; 68:709-35.
13. McKee AC, Gavett B E, Stern R A, Nowinski C J, Cantu R C, Kowall NW, et al. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2010; 69:918-29.
14. Armon C, Nelson L M. I s head trauma a risk factor for amyotrophic lateral sclerosis An evidence based review. Amyotroph Lateral Scler. 2012; 13:351-6.
15. Harwood CA, McDermott CJ, Shaw PJ. Physical activity as an exogenous risk factor in motor neuron disease (MND): a review of the evidence. Amyotroph Lateral Scler. 2009; 10:191-204.
16. McArdle A, Pattwell D, Vasilaki A, Griffi ths R D, Jackson MJ. Contractile activity-induced oxidative stress: cellular origin and adaptive responses. Am J Physiol Cell Physiol. 2001; 280:621-7.
17. Cleveland D W, Rothstein J. F rom Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci. 2001; 2:806-19.
18. Julien J-P. A myotrophic lateral sclerosis: unfolding the toxicity of the misfolded. Cell. 2001; 104:581-91.
19. Veldink JH, Bar PR, Joosten EAJ, Otten M, Wokke JHJ, van den Berg LH. Sexual differences in onset of disease and response to exercise in a transgenic model of ALS. Neuromusc Disord. 2003; 13:737-43.
20. Liebetanz D, Hagemann K, von Lewinski F, Kahler E, Paulus W. Extensive exercise is not harmful in amyotrophic lateral sclerosis. Eur J Neurosci. 2004; 20:3115-20.
21. Mahoney D J, Rodriguez C, Devries M, Yasuda N, Tamopolsky MA. Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis. Muscle Nerve. 2004; 29:656-62.
22. Veldink J H, Kalmijn S, Groeneveld G J, Titulaer M J, Wokke JH, van den Berg LH. Physical activity and the association with sporadic ALS. Neurology. 2005; 64:241-5.
23. Tscholl P. The use of medication and nutritional supplements during FIFA World Cups 2002 and 2006. Br J Sports Med. 2008; 42:725-30.
24. Taioli E. U se of permitted drugs in Italian professional soccer players. Br J Sports Med. 2007; 41:439-41.
25. Bilak M, Wu L, Wang Q, Haughey N, Conant K, St. Hillaire C, et al. PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis. Ann Neurol. 2004; 56:240-8.
26. Zhao W, Xie W, Xiao Q, Beers D, Appel S. P rotective effects of an anti-infl ammatory cytokine, interleukin-4, on motor neuron toxicity induced by activated microglia. J Neurochem. 2006; 99:1176-87.
27. Popat RA, Tanner CM, van den Eeden SK, Bernstein A L, Bloch DA, Leimpeter A, et al. Effect of non-steroidal antiinfl ammatory medications on the risk of amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2007; 8:157-63.
28. Qureshi M, Shui A, Dibernardo AB, Brown RH Jr, Schoenfeld DA, Cudkowicz ME. Medications and laboratory parameters as prognostic factors in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2008; 9:369-74.
29. Fondell E, O ' R eilly EJ, Fitzgerald KC, Falcone GJ, McCullough ML, Thun MJ, et al. Non-steroidal antiinfl ammatory drugs and amyotrophic lateral sclerosis: results from fi ve prospective cohort studies. Amyotroph Lateral Scler. 2012; 13:573-9.
30. Abel EL. F ootball increases the risk for Lou Gehrig' s disease, amyotrophic lateral sclerosis. Percept Mot Skills. 2007; 104:1251-4.
31. Italian ALS Study Group. B ranched-chain amino acids and amyotrophic lateral sclerosis: a treatment failure Neurology. 1993; 43:2466-70.
32. Tandan R, Bromberg MB, Forshew D, Fries TJ, Badger GJ, Carpenter J, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology. 1996; 47:1220-6.
33. Carunchio I, Curcio L, Pieri M, Pica F, Caioli S, Viscomi MT, et al. Increased levels of p70S6 phosphorylation in the G93A mouse of amyotrophic lateral sclerosis and in valine-exposed cortical neurons in culture. Exp Neurol. 2010; 226:218-30.
34. Contrusciere V, Paradisi S, Matteucci A, Melchiodi-Albedi F. Branched-chain amino acids induce neurotoxicity in rat cortical cultures. Neurotoxicity Res. 2010; 17:392-8.
35. Manuel M, Heckman C J. S tronger is not always better: could a bodybuilding dietary supplement lead to ALS Exp Neurol. 2011; 228:5-8.
36. Baker DH. T olerance for branched-chain amino acids in experimental animals and humans. J Nutr. 2005; 135:S1585-90.
37. Hutson SM, Sweatt A J, Lanoue KF. B ranched-chain amino acid metabolism: implications for establishing safe intakes. J Nutr. 2005; 135:S1557-64.
38. McGuire V, Longstreth WT Jr, Nelson LM, Koepsell T D, Checkoway H, Morgan MS, et al. Occupational exposures and amyotrophic lateral sclerosis: a population based casecontrol study. Am J Epidemiol. 1997; 145:1076-88.
39. Govoni V, Granieri E, Fallica E, Casetta I. A myotrophic lateral sclerosis, rural environment and agricultural work in the local health district of Ferrare, Italy, in the years 1964-1998. J Neurol. 2005; 252:1322-7.
40. Park RM, Schulte PA, Bowman JD, Walker JT, Bondy SC, Yost MG, et al. Potential occupational risk for neurodegenerative diseases. Am J Ind Med. 2005; 48:63-77.
41. Qureshi MM, Hayden D, Urbinelli L, Ferrante K, Newhall K, Myers D, et al. Analysis of factors that modify susceptibility and rate of progression in amyotrophic lateral sclerosis (ALS). Amyotroph Lateral Scler. 2006; 7:173-82.
42. Morahan JM, Pamphlett R. A myotrophic lateral sclerosis and exposure to environmental toxins: an Australian casecontrol study. Neuroepidemiology. 2006; 27:130-5.
43. Furby A, Beauvais K, Kolev I, Rivain J G, Sebille V. R ural environment and risk factors of amyotrophic lateral sclerosis: a case-control study. J Neurol. 2010; 257:792-8.
44. Bonvicini F, Marcello N, Mandrioli J, Pietrini V, Vinceti M. Exposure to pesticides and risk of amyotrophic lateral sclerosis: a population based case-control study. Ann Ist Super Sanita. 2010; 46:284-7.
45. Wills AM, Cronin S, Sloweik A, Kasperaviciute D, van Es MA, Morahan JM, et al. A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology. 2008; 73:16-24.
46. Sutedja N A, Fischer K, Veldink J H, van der Heijden GJ, Kromhout H, Heederik D, et al. What we truly know about occupation as a risk factor for ALS: a critical and systematic review. Amyotroph Lateral Scler. 2009; 10:295-301.
47. Sutedja NA, Veldink JH, Fisher K, Kromhout H, Heederik D, Huisman MH, et al. Exposure to chemicals and metals and risk of amyotrophic lateral sclerosis: a systematic review. Amyotroph Lateral Scler. 2009; 10:302-9.
48. Lehman EJ, Hein MJ, Baron SL, Gersic CM. N eurodegenerative causes of death among retired national Football League players. Neurology. 2012; 79:1970-4.
49. Chiò A, Calvo A, Dossena M, Ghiglione P, Mutani R, Mora G. ALS is Italian professional soccer players: the risk is still present and could be soccer-specifi c. Amyotroph Lateral Scler. 2009; 10:205-9.
50. Wicks P, Ganesalingham J, Collin C, Prevett M, Leigh NP, Al-Chalabi A. Three soccer playing friends with simultaneous amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2007; 8:177-9.
51. Mattsson P, Lö n nstedt I, Nygren I, Askmark H. P hysical fi tness, but not muscle strength, is a risk factor for death in amyotrophic lateral sclerosis at an early age. J Neurol Neurosurg Psychiatry. 2010; 83:390-4.
52. Scarmeas N, Shih T, Stern Y, Ottman R, Rowland LP. Premorbid weight, body mass, and university athletics in ALS. Neurology. 2002; 59:773-5.
53. Al-Chalabi A, Leigh PN. T rouble on the pitch: are professional football players at increased risk of developing amyotrophic lateral sclerosis Brain. 2005; 128:451-3.
54. Holden C. P eering under the hood of Africa' s runners. Science. 2004; 305:637-9.
55. Le Galliard JF, Clobert J, Ferriere R. P hysical performance and Darwinian fi tness in lizards. Nature. 2004; 432:502-5.
56. Vivekananda U, Manjalay Z, Ganesalingam J, Simms J, Shaw CE, Leigh PN, et al. Low index-to-ring fi nger length ratio in sporadic ALS supports prenatally defi ned motor neuronal vulnerability. J Neurol Neurosurg Psychiatry. 2011; 82:635-7.
57. Manning J T, Fink B. D igit ratio (2D:4D), dominance, reproductive success, asymmetry, and sociosexuality in the BBC Internet Study. Am J Hum Biol. 2008; 20:451-61.
58. Hö n ekopp J, Schuster M. A meta-analysis on 2D:4D and athletic prowess: substantial relationships but neither hand out-predicts the other. Pers Indiv Differ. 2010; 48:4-10.
59. Tester N, Campbell A. S porting achievement: what is the contribution of digit ratio J Pers. 2007; 75:663-78.
60. Manning J T, Morris L, Caswell N. E ndurance running and digit ratio (2D: 4D): implications for foetal testosterone effects on running speed and vascular health. Am J Hum Biol. 2007; 19:416-21.
61. Turner M R, Wotton C, Talbot K, Goldacre M J. C ardiovascular fi tness as a risk factor for amyotrophic lateral sclerosis: indirect evidence from record linkage study. J Neurol Neurosurg Psychiatry. 2012; 83:395-8.
62. Huisman MHB, de Jong DW, Verwijs MC, Schelhass HJ, van der Kooi AJ, de Visser M, et al. Family history of neurodegenerative and vascular diseases in ALS, apopulation based study. Neurology. 2011; 77:1363-9.
63. Beghi E. 1 27t h ENMC International Workshop: implementation of a European registry of ALS. Naarden, The Netherlands, 8-10 October 2004. Neuromuscul Disord. 2006; 16:46-53.