A randomised cross-over pharmacokinetic bioavailability study of synthetic versus kiwifruit-derived vitamin C

Nutrients

Volumn 5, Issue 11, 2013, Pages 4451-4461

  Carr, Anitra C ^a   Bozonet, Stephanie M ^a   Vissers, Margreet C M ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Ascorbate; Ascorbic acid; Human; Kiwi fruit; Plasma; Urine

Indexed keywords

ASCORBIC ACID; CREATININE;

ACTINIDIA CHINENSIS; ADULT; ARTICLE; CHEWABLE TABLET; CONTROLLED STUDY; CREATININE URINE LEVEL; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG EXCRETION; DRUG UPTAKE; ELECTROCHEMICAL DETECTION; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; URINALYSIS; URINARY EXCRETION; VITAMIN BLOOD LEVEL;

ACTINIDIA CHINENSIS; ACTINIDIA DELICIOSA;

ACTINIDIA; ADOLESCENT; ADULT; ANTIOXIDANTS; ASCORBIC ACID; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; FASTING; FLAVONOIDS; FRUIT; HUMANS; MALE; VITAMINS; YOUNG ADULT;

EID: 84887489580     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu5114451     Document Type: Article

References (37)

1. Tsao, C.S. An Overview of Ascorbic Acid Chemistry and Biochemistry. In Vitamin C in Health and Disease; Packer, L., Fuchs, J., Eds.; Marcel Dekker: New York, NY, USA, 1997; pp. 25-58.
2. Sauberlich, H.E. A History of Scurvy and Vitamin C. In Vitamin C in Health and Disease; Packer, L., Fuchs, J., Eds.; Marcel Dekker: New York, NY, USA, 1997; pp. 1-24.
3. Ivanov, V.; Carr, A.C.; Frei, B. Red wine antioxidants bind to human lipoproteins and protect them from metal ion-dependent and-independent oxidation. J. Agric. Food Chem. 2001, 49, 4442-4449.
4. Beker, B.Y.; Sonmezoglu, I.; Imer, F.; Apak, R. Protection of ascorbic acid from copper(II)-catalyzed oxidative degradation in the presence of flavonoids: Quercetin, catechin and morin. Int. J. Food Sci. Nutr. 2011, 62, 504-512.
5. Clemetson, C.A.; Andersen, L. Plant polyphenols as antioxidants for ascorbic acid. Ann. N. Y. Acad. Sci. 1966, 136, 341-376.
6. Lotito, S.B.; Frei, B. Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon? Free Radic. Biol. Med. 2006, 41, 1727-1746.
7. Carr, A.; Frei, B. Does vitamin C act as a pro-oxidant under physiological conditions? Faseb J. 1999, 13, 1007-1024.
8. +-dependent L-ascorbic acid transporters. Nature 1999, 399, 70-75.
9. Savini, I.; Rossi, A.; Pierro, C.; Avigliano, L.; Catani, M.V. SVCT1 and SVCT2: Key proteins for vitamin C uptake. Amino Acids 2008, 34, 347-355.
10. Parada, J.; Aguilera, J.M. Food microstructure affects the bioavailability of several nutrients. J. Food Sci. 2007, 72, R21-R32.
11. Kamp, F.; Jandel, D.; Hoenicke, I.; Pietrzk, K.; Gross, R.; Trugo, N.M.; Donangelo, C.M. Bioavailability of iron, zinc, folate, and vitamin C in the IRIS multi-micronutrient supplement: Effect of combination with a milk-based cornstarch porridge. Food Nutr. Bull. 2003, 24 (3 Suppl.), 20-26.
12. Mangels, A.R.; Block, G.; Frey, C.M.; Patterson, B.H.; Taylor, P.R.; Norkus, E.P.; Levander, O.A. The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid. J. Nutr. 1993, 123, 1054-1061.
13. Carr, A.C.; Bozonet, S.M.; Pullar, J.M.; Simcock, J.W.; Vissers, M.C. A randomised steady-state bioavailability study of synthetic and natural (kiwifruit-derived) vitamin C. Nutrients 2013, 5, 3684-3695.
14. Vissers, M.C.M.; Bozonet, S.M.; Pearson, J.F.; Braithwaite, L.J. Dietary ascorbate affects steady state tissue levels in vitamin C-deficient mice: Tissue deficiency after sub-optimal intake and superior bioavailability from a food source (kiwifruit). Am. J. Clin. Nutr. 2011, 93, 292-301.
15. Uchida, E.; Kondo, Y.; Amano, A.; Aizawa, S.; Hanamura, T.; Aoki, H.; Nagamine, K; Koizumi, T.; Maruyama, N.; Ishigami, A. Absorption and excretion of ascorbic acid alone and in acerola (Malpighia emarginata) juice: Comparison in healthy Japanese subjects. Biol. Pharm. Bull. 2011, 34, 1744-1747.
16. Bates, C.J.; Jones, K.S.; Bluck, L.J. Stable isotope-labelled vitamin C as a probe for vitamin C absorption by human subjects. Br. J. Nutr. 2004, 91, 699-705.
17. Jones, E.; Hughes, R.E. The influence of bioflavonoids on the absorption of vitamin C. IRCS Med. Sci. 1984, 12, 320.
18. Pelletier, O.; Keith, M.O. Bioavailability of synthetic and natural ascorbic acid. J. Am. Diet. Assoc. 1974, 64, 271-275.
19. Levine, M.; Conry-Cantilena, C.; Wang, Y.; Welch, R.W.; Washko, P.W.; Dhariwal, K.R.; Park, J.B.; Lazarev, A.; Graumlich, J.K.; King, J.; Cantilena, L.R. Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance. Proc. Natl. Acad. Sci. USA 1996, 93, 3704-3709.
20. Kondo, Y.; Higashi, C.; Iwama, M.; Ishihara, K.; Handa, S.; Mugita, H.; Maruyama, N.; Koga, H.; Ishigami, A. Bioavailability of vitamin C from mashed potatoes and potato chips after oral administration in healthy Japanese men. Br. J. Nutr. 2012, 107, 885-892.
21. Carr, A.C.; Pullar, J.M.; Moran, S.; Vissers, M.C.M. Bioavailability of vitamin C from kiwifruit in non-smoking males: Determination of 'healthy' and 'optimal' intakes. J. Nutr. Sci. 2012, 1, e14, doi:10.1017/jns.2012.15.
22. Sato, Y.; Uchiki, T.; Iwama, M.; Kishimoto, Y.; Takahashi, R.; Ishigami, A. Determination of dehydroascorbic acid in mouse tissues and plasma by using tris(2-carboxyethyl)phosphine hydrochloride as reductant in metaphosphoric acid/ethylenediaminetetraacetic acid solution. Biol. Pharm. Bull. 2010, 33, 364-369.
23. Carter, B.; Monsivais, P.; Drewnowski, A. Absorption of folic acid and ascorbic acid from nutrient comparable beverages. J. Food Sci. 2010, 75, H289-H293.
24. Nadler, S.B.; Hidalgo, J.H.; Bloch, T. Prediction of blood volume in normal human adults. Surgery 1962, 51, 224-232.
25. Guarnieri, S.; Riso, P.; Porrini, M. Orange juice vs. vitamin C: Effect on hydrogen peroxide-induced DNA damage in mononuclear blood cells. Br. J. Nutr. 2007, 97, 639-643.
26. Nelson, E.W.; Streiff, R.R.; Cerda, J.J. Comparative bioavailability of folate and vitamin C from a synthetic and a natural source. Am. J. Clin. Nutr. 1975, 28, 1014-1019.
27. Vinson, J.A.; Bose, P. Comparative bioavailability of synthetic and natural vitamin C in guinea pigs. Nutr. Rep. Int. 1983, 27, 875-879.
28. Vinson, J.A.; Bose, P. Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. Am. J. Clin. Nutr. 1988, 48, 601-604.
29. Graumlich, J.F.; Ludden, T.M.; Conry-Cantilena, C.; Cantilena, L.R., Jr.; Wang, Y.; Levine, M. Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletion. Pharm. Res. 1997, 14, 1133-1139.
30. Carr, A.C.; Bozonet, S.M.; Pullar, J.M.; Simcock, J.W.; Vissers, M.C. Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations. Am. J. Clin. Nutr. 2013, 97, 800-807.
31. Sims, I.M.; Monro, J.A. Fiber: Composition, structures, and functional properties. Adv. Food Nutr. Res. 2013, 68, 81-99.
32. Keltz, F.R.; Kies, C.; Fox, H.M. Urinary ascorbic acid excretion in the human as affected by dietary fiber and zinc. Am. J. Clin. Nutr. 1978, 31, 1167-1171.
33. Lee, D.E.; Shin, B.J.; Hur, H.J.; Kim, J.H.; Kim, J.; Kang, N.J.; Kim, D.O.; Lee, C.Y.; Lee, K.W.; Lee, H.J. Quercetin, the active phenolic component in kiwifruit, prevents hydrogen peroxide-induced inhibition of gap-junction intercellular communication. Br. J. Nutr. 2010, 104, 164-170.
34. Song, J.; Kwon, O.; Chen, S.; Daruwala, R.; Eck, P.; Park, J.B.; Levine, M. Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and glucose. J. Biol. Chem. 2002, 277, 15252-15260.
35. Corpe, C.P.; Tu, H.; Eck, P.; Wang, J.; Faulhaber-Walter, R.; Schnermann, J.; Margolis, S.; Padayatty, S.; Sun, H.; Wang, Y.; Nussbaum, R.L.; Espey, M.G.; Leine, M. Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J. Clin. Investig. 2010, 120, 1069-1083.
36. Yalcin, O.; Karatas, F.; Erulas, F.A.; Ozdemir, E. The levels of glutathione peroxidase, vitamin A, E, C and lipid peroxidation in patients with transitional cell carcinoma of the bladder. BJU Int. 2004, 93, 863-866.
37. Ochoa-Brust, G.J.; Fernandez, A.R.; Villanueva-Ruiz, G.J.; Velasco, R.; Trujillo-Hernandez, B.; Vasquez, C. Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy. Acta Obstet. Gynecol. Scand. 2007, 86, 783-787.