Stable isotope-labelled vitamin C as a probe for vitamin C absorption by human subjects

British Journal of Nutrition

Volumn 91, Issue 5, 2004, Pages 699-705

  Bates, Christopher J ^a   Jones, Kerry S ^a   Bluck, Leslie J C ^a  

^a MRC HUMAN NUTRITION RESEARCH   (United Kingdom)

Author keywords

Absorption; Ascorbate; Human subjects; Stable isotope; Vitamin C

Indexed keywords

ASCORBIC ACID; CARBON 13; FERROUS FUMARATE; POLYPHENOL; TRIMETHYLSILYL DERIVATIVE; VOLATILE AGENT;

ADULT; ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET SUPPLEMENTATION; DILUTION; DRUG ABSORPTION; DRUG DETERMINATION; FLUOROMETRY; GAS CHROMATOGRAPHY; GRAPE JUICE; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; MASS SPECTROMETRY; MOLECULAR PROBE; NORMAL HUMAN; VITAMIN BLOOD LEVEL;

ABSORPTION; ADMINISTRATION, ORAL; ADULT; ASCORBIC ACID; BODY WEIGHT; CARBON DIOXIDE; CARBON ISOTOPES; CITRUS PARADISI; DIETARY SUPPLEMENTS; FEMALE; FERROUS COMPOUNDS; HUMANS; MALE; MIDDLE AGED;

VITIS SP.;

EID: 2542561211     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN20041103     Document Type: Article

References (47)

1. Atkins GL, Dean BM, Griffin WJ & Watts RWE (1964) Quantitative aspects of ascorbic acid metabolism in man. J Biol Chem 239, 2975-2980.
2. Baker EM, Hodges RE, Hood J, Sauberlich HE & March SC (1969) Metabolism of ascorbic-1-14C acid in experimental human scurvy. Am J Clin Nutr 22, 549-558.
3. Bates CJ (1997) Bioavailability of vitamin C. Eur J Clin Nutr 51, S28-S33.
4. Blanchard J (1991) Effects of gender on vitamin C pharmacokinetics in man. J Am Coll Nutr 10, 453-459.
5. Blanchard J, Conrad KA, Mead RA & Garry PJ (1990) Vitamin C disposition in young and elderly men. Am J Clin Nutr 51, 837-845.
6. Blanchard J, Tozer TT & Rowland M (1997) Pharmacokinetic perspectives on megadoses of ascorbic acid. Am J Clin Nutr 66, 1165-1171.
7. Bluck LJC & Coward WA (1997) Peak measurement in gas chromatographic/mass spectrometric isotope studies. J Mass Spectrom 32, 1212-1218.
8. Bluck LJC, Izzard AP & Bates CJ (1996) Measurement of ascorbic acid kinetics in man using stable isotopes and gas chromatography/mass spectrometry. J Mass Spectrom 31, 741-748.
9. 13C labelled tracers compared for kinetic studies of ascorbic acid metabolism in man - a factor analytical approach. Rapid Commun Mass Spectrom 16, 879-883.
10. Clayton MM & Borden RA (1943) The availability for human nutrition of the vitamin C in raw cabbage and home-canned tomato juice. J Nutr 25, 349-369.
11. Clayton MM & Folsom MT (1940) A method for the study of the availability for human nutrition of the vitamin C in foods, with an application to the study of the potato. J Home Econ 32, 390-395.
12. Clegg KM & Morton AD (1968) The phenolic compounds of blackcurrant juice and their protective effects on ascorbic acid. II. The stability of ascorbic acid in model systems containing some of the phenolic compounds associated with blackcurrant juice. J Fd Technol 3, 277-284.
13. Diaz M, Rosado JL, Allen LH & Garcia OP (2003) The efficacy of a local ascorbic acid-rich food in improving iron absorption from Mexican diets: a field study using stable isotopes. Am J Clin Nutr 78, 436-440.
14. Frankel EN, Bosanek CA, Meyer AS, Silliman K & Kirk LL (1998) Commercial grape juices inhibit the in vitro oxidation of human low-density lipoproteins. J Agric Food Chem 46, 834-838.
15. Graumlich JF, Ludden TM, Conry-Cantilena C, Cantilena LR, Wang Y & Levine M (1997) Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletion. Pharmaceut Res 14, 1133-1139.
16. Hankes LV, Jansen CR & Schmaeler M (1974) Ascorbic acid catabolism in Bantu with haemosiderosis (scurvy). Biochem Med 9, 244-255.
17. Harper KA, Morton AD & Rolfe EJ (1969) The phenolic compounds of blackcurrant juice and their protective effects on ascorbic acid. III. The mechanisms of ascorbic acid oxidation and its inhibition by flavonoids. J Fd Technol 4, 255-267.
18. Hartzler ER (1945) The availability of ascorbic acid in papayas and guavas. J Nutr 30, 355-365.
19. Hawley EE, Stephens DJ & Anderson G (1936) The excretion of vitamin C in normal individuals following a comparable quantitative administration in the form of orange juice, cevitamic acid by mouth and cevitamic acid intravenously. J Nutr 11, 135-145.
20. Hopper FC & Ayres AD (1950) The enzymatic degradation of ascorbic acid. Part I - The inhibition of the enzymatic oxidation of ascorbic acid by substances occurring in blackcurrants. J Sci Fd Agric 1, 5-8.
21. Hornig D, Vuilleumier J-P & Hartmann D (1980) Absorption of large, single, oral intakes of ascorbic acid. Int J Vit Nutr Res 50, 309-314.
22. Izzard AP, Bluck LJC & Bates CJ (1996) Measurement of stable isotope [13-C] ascorbate using gas chromatography with mass spectrometry (GCMS). Proc Nutr Soc 55, 88A.
23. Johnston CS & Luo B (1994) Comparison of the absorption and excretion of three commercially available sources of vitamin C. J Am Diet Assoc 94, 779-781.
24. Jones E & Hughes RE (1984) The influence of bioflavonoids on the absorption of vitamin C. IRCS Med Sci 12, 320.
25. Kallner A, Hartmann D & Hornig D (1977a) Determination of bodypool size and turnover rate of ascorbic acid in man. Nutr Metab 21, 31-35.
26. Kallner A, Hartmann D & Hornig D (1977b) On the absorption of ascorbic acid in man. Int J Vit Nutr Res 47, 383-388.
27. Kallner A, Hartmann D & Hornig D (1979) Steady-state turnover and body pool of ascorbic acid in man. Am J Clin Nutr 32, 530-539.
28. Kallner A, Hartmann D & Hornig D (1981) On the requirements of ascorbic acid in man: steady-state turnover and body pool in smokers. Am J Clin Nutr 34, 1347-1355.
29. Kallner A, Hornig D & Pellikka R (1985) Formation of carbon dioxide from ascorbate in man. Am J Clin Nutr 41, 609-613.
30. Lapidot T, Harel S, Granit R & Kanner J (1998) Bioavailability of red wine anthocyanins as detected in human urine. J Agric Food Chem 46, 4297-4302.
31. Levine M, Conry-Cantilena C, Wang Y, et al. (1996) Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 93, 3704-3709.
32. Liang W-J, Johnson D & Jarvis SM (2001) Vitamin C transport systems of mammalian cells. Mol Membr Biol 18, 87-95.
33. Lynch SR, Seftel HC, Torrance JD, Charlton RW & Bothwell TH (1967) Accelerated oxidative catabolism of ascorbic acid in siderotic Bantu. Am J Clin Nutr 20, 641-647.
34. Mangels AR, Block G, Frey CM, Patterson BH, Taylor PR, Norkus EP & Levander OA (1993) The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid. J Nutr 123, 1054-1061.
35. Miller NJ (1998) Flavonoids and phenylpropanols as contributors to the antioxidant activity of fruit juices. In Flavonoids in Health and Disease pp. 387-403 [CA Rice-Evans and L Packer, editors]. New York: Marcel Dekker.
36. Nelson EW, Streiff RR & Cerda JJ (1975) Comparative bioavailability of folate and vitamin C from a synthetic and a natural source. Am J Clin Nutr 28, 1014-1019.
37. Pelletier O & Keith MO (1974) Bioavailability of synthetic and natural ascorbic acid. J Am Diet Assoc 64, 271-275.
38. Piotrovskij VK, Kallay Z, Gajdos M, Gerykova M & Trnovec T (1993) The use of a nonlinear absorption model in the study of ascorbic acid bioavailability in man. Biopharm Drug Dispos 14, 429-442.
39. Rehman A, Collis CS, Yang M, Kelly M, Diplock AT, Halliwell B & Rice-Evans C (1998) The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers. Biochem Biophys Res Commun 246, 293-298.
40. Serafini M, Maiani G & Ferro-Luzzi A (1998) Alcohol-free red wine enhances plasma antioxidant capacity in humans. J Nutr 128, 1003-1007.
41. Song J, Kwon O, Chen S, Daruwala R, Eck P, Park JB & Levine M (2002) Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and glucose. J Biol Chem 277, 15252-15260.
42. Timberlake CF (1960) Metallic components of fruit juices IV. Oxidation and stability of ascorbic acid in blackcurrant juice. J Sci Fd Agric 11, 268-273.
43. Todhunter EN & Fatzer AS (1940) A comparison of the utilisation by college women of equivalent amounts of ascorbic acid (vitamin C) in red raspberries and in crystalline form. J Nutr 19, 121-130.
44. Vinson JA & Bose P (1988) Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. Am J Clin Nutr 48, 601-604.
45. Vuilleumier JP & Keck E (1989) Fluorometric assay of vitamin C in biological materials, using a centrifugal analyser with fluorescence attachment. J Micronutr Anal 5, 25-34.
46. Yang M, Collis CS, Kelly M, Diplock AT & Rice-Evans C (1999) Do iron and vitamin C co-supplementation influence platelet function or LDL oxidizability in healthy volunteers? Eur J Clin Nutr 53, 367-374.
47. Zetler G, Seidel G, Siegers C-P & Iven H (1976) Pharmacokinetics of ascorbic acid in man. Eur J Clin Pharmacol 10, 273-282.