Thioredoxin 1 is inactivated due to oxidation induced by peroxiredoxin under oxidative stress and reactivated by the glutaredoxin system

Journal of Biological Chemistry

Volumn 288, Issue 45, 2013, Pages 32241-32247

  Du, Yatao ^a   Zhang, Huihui ^a   Zhang, Xu ^a   Lu, Jun ^a   Holmgren, Arne ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE RESIDUES; DISULFIDE REDUCTASE; GLUTATHIONE REDUCTASE; PHYSIOLOGICAL CONCENTRATIONS; REDOX REGULATION; REDOX SIGNALING; REDUCTASE ACTIVITY; REVERSIBLE OXIDATION;

AMINO ACIDS; ENZYMES; MAMMALS; OXIDATION; OXIDATIVE STRESS; PEPTIDES;

SULFUR COMPOUNDS;

CYSTEINE; CYSTEINE 32; CYSTEINE 35; CYSTEINE 62; CYSTEINE 69; DISULFIDE; EBSELEN; GLUTAREDOXIN; GLUTATHIONE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; PEROXIREDOXIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL; THIOREDOXIN 1; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME REACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

HYDROGEN PEROXIDE; OXIDATIVE STRESS; PEROXIREDOXIN; REDOX SIGNALING; THIOL; THIOREDOXIN;

GLUTAREDOXINS; GLUTATHIONE; GLUTATHIONE REDUCTASE; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; NADP; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEROXIREDOXINS; SIGNAL TRANSDUCTION; THIOREDOXINS;

EID: 84887478834     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.495150     Document Type: Article

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