Genome-wide association study of the five-factor model of personality in young Korean women

Journal of Human Genetics

Volumn 58, Issue 10, 2013, Pages 667-674

  Kim, Han Na ^a   Roh, Seung Ju ^a   Sung, Yeon Ah ^a   Chung, Hye Won ^a   Lee, Jong Young ^b   Cho, Juhee ^c   Shin, Hocheol ^d   Kim, Hyung Lae ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Korea Centers for Disease Control and Prevention   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Big5 personality; Five factor model; Genome wide association; ORIA2; Personality; Psychiatry

Indexed keywords

DOPAMINE 1 RECEPTOR; DRD3 PROTEIN; NKAIN2 PROTEIN; ORIA2 PROTEIN; PROTEIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE D; SEROTONIN 5A RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGREEABLENESS; ARTICLE; BEHAVIOR GENETICS; CONSCIENTIOUSNESS; ENVIRONMENTAL FACTOR; EXTRAVERSION; FEMALE; GENETIC ASSOCIATION; GENETIC MODEL; HUMAN; KOREA; NEO PERSONALITY INVENTORY; NEUROSIS; NORMAL HUMAN; OPENNESS; PERSONALITY; PERSONALITY TEST; PHENOTYPIC VARIATION; REPLICATION STUDY;

ADOLESCENT; ADULT; ANXIETY DISORDERS; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MEMBRANE PROTEINS; PERSONALITY; PERSONALITY INVENTORY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D3; REPUBLIC OF KOREA; YOUNG ADULT;

EID: 84887473103     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2013.75     Document Type: Article

References (68)

1. McCrae, R. R. & Costa, P. T. Personality in Adulthood: A Five-Factor Theory Perspective. 2nd edn, (Guilford Press, New York, NY, USA, 2003
2. Costa, P. & McCrae, R. Professional Manual: Tevised NEO Personality Inventory (NEOPI- R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual (Psychological Assessment Resources: Odessa, Odessa, FL, USA (1992
3. Soto, C. J., John, O. P., Gosling, S. D. & Potter, J. Age Differences in Personality Traits From 10 to 65: Big Five Domains and Facets in a Large Cross-Sectional Sample. J. Pers. Soc. Psychol. 100, 330-348 (2011
4. Srivastava, S., John, O. P., Gosling, S. D. & Potter, J. Development of personality in early and middle adulthood: Set like plaster or persistent change? J. Pers. Soc. Psychol. 84, 1041-1053 (2003
5. Allemand, M., Zimprich, D. & Hendriks, A. A. J. Age differences in five personality domains across the life span. Dev. Psychol. 44, 758-770 (2008
6. Roberts, B. W., Walton, K. E. & Viechtbauer, W. Patterns of mean-level change in personality traits across the life course: A meta-Analysis of longitudinal studies. Psychol. Bull. 132, 1-25 (2006
7. Horn, J. M., Plomin, R. & Rosenman, R. Heritability of personality traits in adult male twins. Behav. Genet. 6, 17-30 (1976
8. Floderus-Myrhed, B., Pedersen, N. & Rasmuson, I. Assessment of heritability for personality, based on a short-form of the Eysenck Personality Inventory: A study of 12,898 twin pairs. Behav. Genet. 10, 153-162 (1980
9. Jang, K. L., Livesley, W. J. & Vernon, P. A. Heritability of the big five personality dimensions and their facets: A twin study. J. Pers. 64, 577-591 (1996
10. Benjamin, J., Li, L., Patterson, C., Greenberg, B. D., Murphy, D. L. & Hamer, D. H. Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat. Genet. 12, 81-84 (1996
11. Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D. et al. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nat. Genet. 12, 78-80 (1996
12. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S. et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527-1531 (1996
13. Alfimova, M. V., Monakhov, M. V., Golimbet, V. E., Korovaitseva, G. I. & Lyashenko, G. L. Analysis of associations between 5-HTT, 5-HTR2A, and GABRA6 gene polymorphisms and health-Associated personality traits. Bull. Exp. Biol. Med. 149, 434-436 (2010
14. Ebstein, R. P., Segman, R., Benjamin, J., Osher, Y., Nemanov, L. & Belmaker, R. H. 5- HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: Interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms. Am. J. Med. Genet. 74, 65-72 (1997
15. Terracciano, A., Sanna, S., Uda, M., Deiana, B., Usala, G., Busonero, F. et al. Genomewide association scan for five major dimensions of personality. Mol. Psychiatry 15 647-656 (2010
16. Verweij, K. J., Zietsch, B. P., Medland, S. E., Gordon, S. D., Benyamin, B., Nyholt, D. R. et al. A genome-wide association study of Cloninger's temperament scales: Implications for the evolutionary genetics of personality. Biol. Psychol. 85, 306-317 (2010
17. de Moor, M. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J., Toshiko, T. et al. Meta-Analysis of genome-wide association studies for personality. Mol. Psychiatry 17, 337-349 (2012
18. Service, S. K., Verweij, K. J., Lahti, J., Congdon, E., Ekelund, J., Hintsanen, M. et al. A genome-wide meta-Analysis of association studies of Cloninger's Temperament Scales. Transl. Psychiatry 2, e116 (2012
19. Ahn, C. K. & Chae, J. H. Standardization of the Korean version of the Revised NEO Personality Inventory. Korean J. Counsel. Psychother. 9, 443-473 (1997
20. Piedmont, R. L. & Chae, J. H. Cross-cultural generalizability of the Five-Factor Model of personality: Development and validation of the NEO-PI-R for Koreans. J. Cross. Cult. Psychol. 28, 131-155 (1997
21. McCrae, R. R. & Terracciano, A. Personality Profiles of Cultures P. Universal features of personality traits from the observer's perspective: Data from 50 cultures. J. Pers. Soc. Psychol. 88, 547-561 (2005
22. Costa, P. & McCrae, R. Trait Psychology Comes of Age (University of Nebraska Press Lincoln, Nebraska Symp on Motivation 1991, 1992
23. Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A., Bender, D. et al. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007
24. Browning, B. L. & Browning, S. R. A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am. J. Hum. Genet. 84, 210-223 (2009
25. Li, M. X., Yeung, J. M., Cherny, S. S. & Sham, P. C. Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets. Hum. Genet. 131, 747-756 (2012
26. Devlin, B & Roeder, K. Genomic control for association studies. Biometrics 55 997-1004 (1999
27. Perlis, R. H., Purcell, S., Fagerness, J., Kirby, A., Petryshen, T. L., Fan, J. et al. Familybased association study of lithium-related and other candidate genes in bipolar disorder. Arch. Gen. Psychiatry 65, 53-61 (2008
28. Zhu, F., Yan, C. X., Wang, Q., Zhu, Y. S., Zhao, Y., Huang, J. et al. An association study between dopamine D1 receptor gene polymorphisms and the risk of schizophrenia. Brain. Res. 1420, 106-113 (2011
29. Hettinger, J. A., Liu, X., Schwartz, C. E., Michaelis, R. C. & Holden, J. J. A DRD1 haplotype is associated with risk for autism spectrum disorders in male-only affected sib-pair families. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 147B, 628-636 (2008
30. Gao, X. P., Su, L. Y., Zhao, A. L., Luo, X. R. & Xia, K. [Association of 14 polymorphisms in the five candidate genes and attention deficit hyperactivity disorder]. Zhongguo dang dai er ke za zhi 11, 617-622 (2009
31. Huang, W., Ma, J. Z., Payne, T. J., Beuten, J., Dupont, R. T. & Li, M. D. Significant association of DRD1 with nicotine dependence. Hum. Genet. 123, 133-140 (2008
32. Batel, P., Houchi, H., Daoust, M., Ramoz, N., Naassila, M. & Gorwood, P. A haplotype of the DRD1 gene is associated with alcohol dependence. Alcohol. Clin. Exp. Res. 32 567-572 (2008
33. Croy, I., Springborn, M., Lotsch, J., Johnston, A. N. & Hummel, T. Agreeable smellers and sensitive neurotics-correlations among personality traits and sensory thresholds. PLoS One 6, e18701 (2011
34. Calboli, F. C., Tozzi, F., Galwey, N. W., Antoniades, A., Mooser, V., Preisig, M. et al. A genome-wide association study of neuroticism in a population-based sample. PLoS One 5, e11504 (2010
35. Bocciardi, R., Giorda, R., Marigo, V., Zordan, P., Montanaro, D., Gimelli, S. et al. Molecular characterization of a t(2;6) balanced translocation that is associated with a complex phenotype and leads to truncation of the TCBA1 gene. Hum. Mutat. 26 426-436 (2005
36. Terracciano, A., Tanaka, T., Sutin, A. R., Deiana, B., Balaci, L., Sanna, S. et al. BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology 35, 1083-1089 (2010
37. Yosifova, A., Mushiroda, T., Stoianov, D., Vazharova, R., Dimova, I., Karachanak, S. et al. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. J. Affect. Disord. 117, 87-97 (2009
38. Dominguez, E., Loza, M. I., Padin, F., Gesteira, A., Paz, E., Paramo, M. et al. Extensive linkage disequilibrium mapping at HTR2A and DRD3 for schizophrenia susceptibility genes in the Galician population. Schizophr. Res. 90, 123-129 (2007
39. Staner, L., Hilger, C., Hentges, F., Monreal, J., Hoffmann, A., Couturier, M. et al. Association between novelty-seeking and the dopamine D3 receptor gene in bipolar patients: A preliminary report. Am. J. Med. Genet. 81, 192-194 (1998
40. Henderson, A. S., Korten, A. E., Jorm, A. F., Jacomb, P. A., Christensen, H., Rodgers B. et al. COMT and DRD3 polymorphisms, environmental exposures, and personality traits related to common mental disorders. Am. J. Med. Genet. 96, 102-107 (2000
41. Grupe, A., Li, Y., Rowland, C., Nowotny, P., Hinrichs, A. L., Smemo, S. et al. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Am. J. Hum. Genet. 78, 78-88 (2006
42. Shifman, S., Bhomra, A., Smiley, S., Wray, N. R., James, M. R., Martin, N. G. et al. A whole genome association study of neuroticism using DNA pooling. Mol. Psychiatry 13, 302-312 (2008
43. van den Oord, E. J., Kuo, P. H., Hartmann, A. M., Webb, B. T., Moller, H. J. Hettema, J. M. et al. Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. Arch. Gen. Psychiatry 65 1062-1071 (2008
44. Costa, P. T. Jr, Terracciano, A. & McCrae, R. R. Gender differences in personality traits across cultures: Tobust and surprising findings. J. Pers. Soc. Psychol. 81, 322-331 (2001
45. Berenbaum, S. A. Effects of early androgens on sex-Typed activities and interests in adolescents with congenital adrenal hyperplasia. Horm. Behav. 35, 102-110 (1999
46. Hollis, J., Allen, P. M., Fleischmann, D. & Aulak, R. Personality dimensions of people who suffer from visual stress. Ophthalmic Physiol. Opt. 27, 603-610 (2007
47. Welge-Lussen, A. Ageing, neurodegeneration, and olfactory and gustatory loss. B-Ent 5 (Suppl 13), 129-132 (2009
48. Fillingim, R. B., King, C. D., Ribeiro-Dasilva, M. C., Rahim-Williams, B. & Riley, J. L. 3rd Sex, gender, and pain: A review of recent clinical and experimental findings. J. Pain 10, 447-485 (2009
49. P., Mettina, M. F., Roman, & G., Fehm-Wolfsdorf Personality and olfactory sensitivity. J. Res. Pers. 32, 510-518 (1998
50. Eysenck, H. J. & Eysenck, M. W. Personality and Individual Differences (Plenum Press: New York, NY, USA 1985
51. Johnson, K. G. & Van Vactor, D. Receptor protein tyrosine phosphatases in nervous system development. Physiol. Rev. 83, 1-24 (2003
52. Van Vactor, D. Protein tyrosine phosphatases in the developing nervous system. Curr. Opin. Cell Biol. 10, 174-181 (1998
53. De Fruyt, F., Van De Wiele, L. & Van Heeringen, C. Cloninger's psychobiological model of temperament and character and the five-factor model of personality. Pers. Individ. Dif. 29, 441-452 (2000
54. Zhang, P., Xiang, N., Chen, Y., Sliwerska, E., McInnis, M. G., Burmeister, M. et al. Family-based association analysis to finemap bipolar linkage peak on chromosome 8q24 using 2500 genotyped SNPs and 15000 imputed SNPs. Bipolar. Disord. 12 786-792 (2010
55. Chen, C., Zhou, Z., Li, M., Qu, M., Ma, Q., Zhong, M. et al. Presenilin-2 polymorphisms and risk of sporadic AD: Evidence from a meta-Analysis. Gene 503, 194-199 (2012
56. Shamir, A., Kwon, O. B., Karavanova, I., Vullhorst, D., Leiva-Salcedo, E., Janssen, M. J. et al. The importance of the NRG-1/ErbB4 pathway for synaptic plasticity and behaviors associated with psychiatric disorders. J. Neurosci. 32, 2988-2997 (2012
57. Rutten, K., Van Donkelaar, E. L., Ferrington, L., Blokland, A., Bollen, E., Steinbusch H. W. et al. Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats. Neuropsychopharmacology 34 1914-1925 (2009
58. Tang, J., Chen, X., Xu, X., Wu, R., Zhao, J., Hu, Z. et al. Significant linkage and association between a functional (GT)n polymorphism in promoter of the N-methyl-Daspartate receptor subunit gene (GRIN2A) and schizophrenia. Neurosci. Lett. 409 80-82 (2006
59. Wang, K. S., Liu, X. F. & Aragam, N. A genome-wide meta-Analysis identifies novel loci associated with schizophrenia and bipolar disorder. Schizophr. Res. 124, 192-199 (2010
60. Fon, E. A., Sarrazin, J., Meunier, C., Alarcia, J., Shevell, M. I., Philippe, A. et al. Adenylosuccinate lyase (ADSL) and infantile autism: Absence of previously reported point mutation. Am. J. Med. Genet. 60, 554-557 (1995
61. Vogler, C., Spalek, K., Aerni, A., Demougin, P., Muller, A., Huynh, K. D. et al. CPEB3 is associated with human episodic memory. Front. Behav. Neurosci. 3, 4 (2009
62. Denkova, E., Dolcos, S. & Dolcos, F. Reliving emotional personal memories: Affective biases linked to personality and sex-related differences. Emotion 12, 515-528 (2012
63. Carlson, R. & Levy, N. Studies of Jungian typology. I. Memory, social perception, and social action. J. Pers. 41, 559-576 (1973
64. Cuttler, C. & Graf, P. Personality predicts prospective memory task performance: An adult lifespan study. Scand. J. Psychol. 48, 215-231 (2007
65. Prinzie, P., Stams, G. J., Dekovic, M., Reijntjes, A. H. & Belsky, J. The relations between parents' Big Five personality factors and parenting: A meta-Analytic review. J. Pers. Soc. Psychol. 97, 351-362 (2009
66. Haan, N., Millsap, R. & Hartka, E. As time goes by: Change and stability in personality over fifty years. Psychol. Aging. 1, 220-232 (1986
67. Hogan, R. A Socioanalytic Perspective on the Five-Factor Model (Guilford Press, New York, NY, USA, 1996
68. Zhong, H. & Prentice, R. L. Correcting 'winner's curse' in odds ratios from genomewide association findings for major complex human diseases. Genet. Epidemiol. 34, 78-91 (2010