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Volumn 3 FEB, Issue , 2013, Pages

Salient features of mesenchymal stem cells-implications for Ewing sarcoma modeling

Author keywords

Ewing sarcoma; EWS FLI1; Mesenchymal stem cells; Models; Molecular; Stem cells

Indexed keywords

CD133 ANTIGEN; COL11A1; INTERSTITIAL COLLAGENASE; PROTEIN P21; PROTEIN P53; SOMATOMEDIN C RECEPTOR; TELOMERASE; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR NKX2; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

EID: 84887448247     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00024     Document Type: Review
Times cited : (9)

References (81)
  • 1
    • 7244226366 scopus 로고    scopus 로고
    • Oncogenic transformation of human cells: shortcomings of rodent model systems
    • Akagi, T. (2004). Oncogenic transformation of human cells: shortcomings of rodent model systems. Trends Mol. Med. 10, 542-548.
    • (2004) Trends Mol. Med. , vol.10 , pp. 542-548
    • Akagi, T.1
  • 2
    • 0032588831 scopus 로고    scopus 로고
    • Relation of neurological marker expression and EWS gene fusion types in MIC2/CD99-positive tumors of the Ewing family
    • Amann, G., Zoubek, A., Salzer-Kuntschik, M., Windhager, R., and Kovar, H. (1999). Relation of neurological marker expression and EWS gene fusion types in MIC2/CD99-positive tumors of the Ewing family. Hum. Pathol. 30, 1058-1064.
    • (1999) Hum. Pathol. , vol.30 , pp. 1058-1064
    • Amann, G.1    Zoubek, A.2    Salzer-Kuntschik, M.3    Windhager, R.4    Kovar, H.5
  • 3
    • 0026032050 scopus 로고
    • MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration
    • Ambros, I. M., Ambros, P. F., Strehl, S., Kovar, H., Gadner, H., and Salzer-Kuntschik, M. (1991). MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 67, 1886-1893.
    • (1991) Cancer , vol.67 , pp. 1886-1893
    • Ambros, I.M.1    Ambros, P.F.2    Strehl, S.3    Kovar, H.4    Gadner, H.5    Salzer-Kuntschik, M.6
  • 4
    • 27144523169 scopus 로고    scopus 로고
    • Gene expression profiling of human sarcomas: insights into sarcoma biology
    • Baird, K., Davis, S., Antonescu, C. R., Harper, U. L., Walker, R. L., Chen, Y., et al. (2005). Gene expression profiling of human sarcomas: insights into sarcoma biology. Cancer Res. 65, 9226-9235.
    • (2005) Cancer Res. , vol.65 , pp. 9226-9235
    • Baird, K.1    Davis, S.2    Antonescu, C.R.3    Harper, U.L.4    Walker, R.L.5    Chen, Y.6
  • 5
    • 34547122719 scopus 로고    scopus 로고
    • Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow
    • Baksh, D., Yao, R., and Tuan, R. S. (2007). Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 25, 1384-1392.
    • (2007) Stem Cells , vol.25 , pp. 1384-1392
    • Baksh, D.1    Yao, R.2    Tuan, R.S.3
  • 6
    • 0035967892 scopus 로고    scopus 로고
    • The evolving concept of a stem cell: entity or function?
    • Blau, H. M., Brazelton, T. R., and Weimann, J. M. (2001). The evolving concept of a stem cell: entity or function? Cell 105, 829-841.
    • (2001) Cell , vol.105 , pp. 829-841
    • Blau, H.M.1    Brazelton, T.R.2    Weimann, J.M.3
  • 7
    • 33845425959 scopus 로고    scopus 로고
    • Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma
    • Braunreiter, C. L., Hancock, J. D., Coffin, C. M., Boucher, K. M., and Lessnick, S. L. (2006). Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma. Cell Cycle 5, 2753-2759.
    • (2006) Cell Cycle , vol.5 , pp. 2753-2759
    • Braunreiter, C.L.1    Hancock, J.D.2    Coffin, C.M.3    Boucher, K.M.4    Lessnick, S.L.5
  • 9
    • 58449135981 scopus 로고    scopus 로고
    • Why are MSCs therapeutic? New data: new insight
    • Caplan, A. I. (2009). Why are MSCs therapeutic? New data: new insight. J. Pathol. 217, 318-324.
    • (2009) J. Pathol. , vol.217 , pp. 318-324
    • Caplan, A.I.1
  • 10
    • 25444507396 scopus 로고    scopus 로고
    • Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors
    • Castillero-Trejo, Y., Eliazer, S., Xiang, L., Richardson, J. A., and Ilaria, R. L. Jr. (2005). Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors. Cancer Res. 65, 8698-8705.
    • (2005) Cancer Res. , vol.65 , pp. 8698-8705
    • Castillero-Trejo, Y.1    Eliazer, S.2    Xiang, L.3    Richardson, J.A.4    Ilaria Jr., R.L.5
  • 11
    • 36248932643 scopus 로고    scopus 로고
    • Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing
    • Chamberlain, G., Fox, J., Ashton, B., and Middleton, J. (2007). Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25, 2739-2749.
    • (2007) Stem Cells , vol.25 , pp. 2739-2749
    • Chamberlain, G.1    Fox, J.2    Ashton, B.3    Middleton, J.4
  • 12
    • 84863136375 scopus 로고    scopus 로고
    • Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures
    • Chen, H. T., Lee, M. J., Chen, C. H., Chuang, S. C., Chang, L. F., Ho, M. L., et al. (2012). Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures. J. Cell. Mol. Med. 16, 582-593.
    • (2012) J. Cell. Mol. Med. , vol.16 , pp. 582-593
    • Chen, H.T.1    Lee, M.J.2    Chen, C.H.3    Chuang, S.C.4    Chang, L.F.5    Ho, M.L.6
  • 13
    • 0034724369 scopus 로고    scopus 로고
    • Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow
    • Colter, D. C., Class, R., DiGirolamo, C. M., and Prockop, D. J. (2000). Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc. Natl. Acad. Sci. U.S.A. 97, 3213-3218.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 3213-3218
    • Colter, D.C.1    Class, R.2    DiGirolamo, C.M.3    Prockop, D.J.4
  • 14
    • 0033007353 scopus 로고    scopus 로고
    • Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow
    • D'Ippolito, G., Schiller, P. C., Ricordi, C., Roos, B. A., and Howard, G. A. (1999). Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow. J. Bone Miner. Res. 14, 1115-1122.
    • (1999) J. Bone Miner. Res. , vol.14 , pp. 1115-1122
    • D'Ippolito, G.1    Schiller, P.C.2    Ricordi, C.3    Roos, B.A.4    Howard, G.A.5
  • 15
    • 0027932782 scopus 로고
    • The Ewing family of tumors-a subgroup of small-round-cell tumors defined by specific chimeric transcripts
    • Delattre, O., Zucman, J., Melot, T., Garau, X. S., Zucker, J. M., Lenoir, G. M., et al. (1994). The Ewing family of tumors-a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N. Engl. J. Med. 331, 294-299.
    • (1994) N. Engl. J. Med. , vol.331 , pp. 294-299
    • Delattre, O.1    Zucman, J.2    Melot, T.3    Garau, X.S.4    Zucker, J.M.5    Lenoir, G.M.6
  • 16
    • 0030007687 scopus 로고    scopus 로고
    • Differentiation potential of conditionally immortalized mesenchymal progenitor cells from adult marrow of a H-2Kb-tsA58 transgenic mouse
    • Dennis, J. E., and Caplan, A. I. (1996). Differentiation potential of conditionally immortalized mesenchymal progenitor cells from adult marrow of a H-2Kb-tsA58 transgenic mouse. J. Cell. Physiol. 167, 523-538.
    • (1996) J. Cell. Physiol. , vol.167 , pp. 523-538
    • Dennis, J.E.1    Caplan, A.I.2
  • 17
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement
    • Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F., Krause, D., et al. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy 8, 315-317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5    Krause, D.6
  • 18
    • 0037218795 scopus 로고    scopus 로고
    • Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma
    • Eliazer, S., Spencer, J., Ye, D., Olson, E., and Ilaria, R. L. Jr. (2003). Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma. Mol. Cell. Biol. 23, 482-492.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 482-492
    • Eliazer, S.1    Spencer, J.2    Ye, D.3    Olson, E.4    Ilaria Jr., R.L.5
  • 19
    • 77955660007 scopus 로고    scopus 로고
    • Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma
    • Gangwal, K., Close, D., Enriquez, C. A., Hill, C. P., and Lessnick, S. L. (2010). Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma. Genes Cancer 1, 177-187.
    • (2010) Genes Cancer , vol.1 , pp. 177-187
    • Gangwal, K.1    Close, D.2    Enriquez, C.A.3    Hill, C.P.4    Lessnick, S.L.5
  • 21
    • 63349090507 scopus 로고    scopus 로고
    • The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function
    • doi: 10.1371/journal.pone.0004932
    • Guillon, N., Tirode, F., Boeva, V., Zynovyev, A., Barillot, E., and Delattre, O. (2009). The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function. PLoS ONE 4:e4932. doi: 10.1371/journal.pone.0004932
    • (2009) PLoS ONE , vol.4
    • Guillon, N.1    Tirode, F.2    Boeva, V.3    Zynovyev, A.4    Barillot, E.5    Delattre, O.6
  • 22
    • 0029162992 scopus 로고
    • Detection of maternal cells in human umbilical cord blood using fluorescence in situ hybridization
    • Hall, J. M., Lingenfelter, P., Adams, S. L., Lasser, D., Hansen, J. A., and Bean, M. A. (1995). Detection of maternal cells in human umbilical cord blood using fluorescence in situ hybridization. Blood 86, 2829-2832.
    • (1995) Blood , vol.86 , pp. 2829-2832
    • Hall, J.M.1    Lingenfelter, P.2    Adams, S.L.3    Lasser, D.4    Hansen, J.A.5    Bean, M.A.6
  • 23
    • 79955795428 scopus 로고    scopus 로고
    • Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC
    • doi: 10.1186/1478-811X-9-12
    • Hass, R., Kasper, C., Bohm, S., and Jacobs, R. (2011). Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. Cell Commun. Signal. 9:12. doi: 10.1186/1478-811X-9-12
    • (2011) Cell Commun. Signal. , vol.9 , pp. 12
    • Hass, R.1    Kasper, C.2    Bohm, S.3    Jacobs, R.4
  • 24
    • 19644386697 scopus 로고    scopus 로고
    • EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors
    • Hu-Lieskovan, S., Zhang, J., Wu, L., Shimada, H., Schofield, D. E., and Triche, T. J. (2005). EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res. 65, 4633-4644.
    • (2005) Cancer Res. , vol.65 , pp. 4633-4644
    • Hu-Lieskovan, S.1    Zhang, J.2    Wu, L.3    Shimada, H.4    Schofield, D.E.5    Triche, T.J.6
  • 25
    • 39149130361 scopus 로고    scopus 로고
    • Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
    • Jaenisch, R., and Young, R. (2008). Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 132, 567-582.
    • (2008) Cell , vol.132 , pp. 567-582
    • Jaenisch, R.1    Young, R.2
  • 26
    • 28044468016 scopus 로고    scopus 로고
    • EWS-ETS oncoproteins: the linchpins of Ewing tumors
    • Janknecht, R. (2005). EWS-ETS oncoproteins: the linchpins of Ewing tumors. Gene 363, 1-14.
    • (2005) Gene , vol.363 , pp. 1-14
    • Janknecht, R.1
  • 27
    • 65549090018 scopus 로고    scopus 로고
    • A molecular function map of Ewing's sarcoma
    • doi: 10.1371/journal.pone.0005415
    • Kauer, M., Ban, J., Kofler, R., Walker, B., Davis, S., Meltzer, P., et al. (2009). A molecular function map of Ewing's sarcoma. PLoS ONE 4:e5415. doi: 10.1371/journal.pone.0005415
    • (2009) PLoS ONE , vol.4
    • Kauer, M.1    Ban, J.2    Kofler, R.3    Walker, B.4    Davis, S.5    Meltzer, P.6
  • 28
    • 33745437684 scopus 로고    scopus 로고
    • Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    • Kern, S., Eichler, H., Stoeve, J., Kluter, H., and Bieback, K. (2006). Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24, 1294-1301.
    • (2006) Stem Cells , vol.24 , pp. 1294-1301
    • Kern, S.1    Eichler, H.2    Stoeve, J.3    Kluter, H.4    Bieback, K.5
  • 29
    • 33845344030 scopus 로고    scopus 로고
    • NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma
    • Kinsey, M., Smith, R., and Lessnick, S. L. (2006). NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. Mol. Cancer Res. 4, 851-859.
    • (2006) Mol. Cancer Res. , vol.4 , pp. 851-859
    • Kinsey, M.1    Smith, R.2    Lessnick, S.L.3
  • 30
    • 33750310480 scopus 로고    scopus 로고
    • CD99-positive "Ewing's sarcoma" from mouse-bone marrow-derived mesenchymal progenitor cells?
    • author reply: 9786
    • Kovar, H., and Bernard, A. (2006). CD99-positive "Ewing's sarcoma" from mouse-bone marrow-derived mesenchymal progenitor cells? Cancer Res. 66, 9786. author reply: 9786.
    • (2006) Cancer Res. , vol.66 , pp. 9786
    • Kovar, H.1    Bernard, A.2
  • 31
    • 0025362710 scopus 로고
    • Overexpression of the pseudoautosomal gene MIC2 in Ewing's sarcoma and peripheral primitive neuroectodermal tumor
    • Kovar, H., Dworzak, M., Strehl, S., Schnell, E., Ambros, I. M., Ambros, P. F., et al. (1990). Overexpression of the pseudoautosomal gene MIC2 in Ewing's sarcoma and peripheral primitive neuroectodermal tumor. Oncogene 5, 1067-1070.
    • (1990) Oncogene , vol.5 , pp. 1067-1070
    • Kovar, H.1    Dworzak, M.2    Strehl, S.3    Schnell, E.4    Ambros, I.M.5    Ambros, P.F.6
  • 32
    • 1442356953 scopus 로고    scopus 로고
    • Isolation of multipotent mesenchymal stem cells from umbilical cord blood
    • Lee, O. K., Kuo, T. K., Chen, W. M., Lee, K. D., Hsieh, S. L., and Chen, T. H. (2004). Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 103, 1669-1675.
    • (2004) Blood , vol.103 , pp. 1669-1675
    • Lee, O.K.1    Kuo, T.K.2    Chen, W.M.3    Lee, K.D.4    Hsieh, S.L.5    Chen, T.H.6
  • 33
    • 0029116176 scopus 로고
    • A chemically defined medium supports in vitro proliferation and maintains the osteochondral potential of rat marrow-derived mesenchymal stem cells
    • Lennon, D. P., Haynesworth, S. E., Young, R. G., Dennis, J. E., and Caplan, A. I. (1995). A chemically defined medium supports in vitro proliferation and maintains the osteochondral potential of rat marrow-derived mesenchymal stem cells. Exp. Cell Res. 219, 211-222.
    • (1995) Exp. Cell Res. , vol.219 , pp. 211-222
    • Lennon, D.P.1    Haynesworth, S.E.2    Young, R.G.3    Dennis, J.E.4    Caplan, A.I.5
  • 34
    • 0036560740 scopus 로고    scopus 로고
    • The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
    • Lessnick, S. L., Dacwag, C. S., and Golub, T. R. (2002). The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 1, 393-401.
    • (2002) Cancer Cell , vol.1 , pp. 393-401
    • Lessnick, S.L.1    Dacwag, C.S.2    Golub, T.R.3
  • 35
    • 78049248010 scopus 로고    scopus 로고
    • The Ewing's sarcoma fusion protein, EWS-FLI, binds Runx2 and blocks osteoblast differentiation
    • Li, X., McGee-Lawrence, M. E., Decker, M., and Westendorf, J. J. (2010). The Ewing's sarcoma fusion protein, EWS-FLI, binds Runx2 and blocks osteoblast differentiation. J. Cell. Biochem. 111, 933-943.
    • (2010) J. Cell. Biochem. , vol.111 , pp. 933-943
    • Li, X.1    McGee-Lawrence, M.E.2    Decker, M.3    Westendorf, J.J.4
  • 36
    • 55349094311 scopus 로고    scopus 로고
    • EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model
    • Lin, P. P., Pandey, M. K., Jin, F., Xiong, S., Deavers, M., Parant, J. M., et al. (2008). EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res. 68, 8968-8975.
    • (2008) Cancer Res. , vol.68 , pp. 8968-8975
    • Lin, P.P.1    Pandey, M.K.2    Jin, F.3    Xiong, S.4    Deavers, M.5    Parant, J.M.6
  • 38
    • 33746936122 scopus 로고    scopus 로고
    • Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials
    • Lu, L. L., Liu, Y. J., Yang, S. G., Zhao, Q. J., Wang, X., Gong, W., et al. (2006). Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica 91, 1017-1026.
    • (2006) Haematologica , vol.91 , pp. 1017-1026
    • Lu, L.L.1    Liu, Y.J.2    Yang, S.G.3    Zhao, Q.J.4    Wang, X.5    Gong, W.6
  • 39
    • 70450184674 scopus 로고    scopus 로고
    • GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance
    • Luo, W., Gangwal, K., Sankar, S., Boucher, K. M., Thomas, D., and Lessnick, S. L. (2009). GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance. Oncogene 28, 4126-4132.
    • (2009) Oncogene , vol.28 , pp. 4126-4132
    • Luo, W.1    Gangwal, K.2    Sankar, S.3    Boucher, K.M.4    Thomas, D.5    Lessnick, S.L.6
  • 41
    • 78649733250 scopus 로고    scopus 로고
    • Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art
    • Malgieri, A., Kantzari, E., Patrizi, M. P., and Gambardella, S. (2010). Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art. Int. J. Clin. Exp. Med. 3, 248-269.
    • (2010) Int. J. Clin. Exp. Med. , vol.3 , pp. 248-269
    • Malgieri, A.1    Kantzari, E.2    Patrizi, M.P.3    Gambardella, S.4
  • 42
    • 0030885841 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow
    • Martin, I., Muraglia, A., Campanile, G., Cancedda, R., and Quarto, R. (1997). Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 138, 4456-4462.
    • (1997) Endocrinology , vol.138 , pp. 4456-4462
    • Martin, I.1    Muraglia, A.2    Campanile, G.3    Cancedda, R.4    Quarto, R.5
  • 43
    • 0027230568 scopus 로고
    • Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation
    • May, W. A., Gishizky, M. L., Lessnick, S. L., Lunsford, L. B., Lewis, B. C., Delattre, O., et al. (1993a). Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc. Natl. Acad. Sci. U.S.A. 90, 5752-5756.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 5752-5756
    • May, W.A.1    Gishizky, M.L.2    Lessnick, S.L.3    Lunsford, L.B.4    Lewis, B.C.5    Delattre, O.6
  • 44
    • 0027362619 scopus 로고
    • The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
    • May, W. A., Lessnick, S. L., Braun, B. S., Klemsz, M., Lewis, B. C., Lunsford, L. B., et al. (1993b). The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol. Cell. Biol. 13, 7393-7398.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7393-7398
    • May, W.A.1    Lessnick, S.L.2    Braun, B.S.3    Klemsz, M.4    Lewis, B.C.5    Lunsford, L.B.6
  • 46
    • 33745433769 scopus 로고    scopus 로고
    • Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation
    • Miura, M., Miura, Y., Padilla-Nash, H. M., Molinolo, A. A., Fu, B., Patel, V., et al. (2006). Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells 24, 1095-1103.
    • (2006) Stem Cells , vol.24 , pp. 1095-1103
    • Miura, M.1    Miura, Y.2    Padilla-Nash, H.M.3    Molinolo, A.A.4    Fu, B.5    Patel, V.6
  • 47
    • 41149089612 scopus 로고    scopus 로고
    • Inducible expression of chimeric EWS/ETS proteins confers Ewing's family tumor-like phenotypes to human mesenchymal progenitor cells
    • Miyagawa, Y., Okita, H., Nakaijima, H., Horiuchi, Y., Sato, B., Taguchi, T., et al. (2008). Inducible expression of chimeric EWS/ETS proteins confers Ewing's family tumor-like phenotypes to human mesenchymal progenitor cells. Mol. Cell. Biol. 28, 2125-2137.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 2125-2137
    • Miyagawa, Y.1    Okita, H.2    Nakaijima, H.3    Horiuchi, Y.4    Sato, B.5    Taguchi, T.6
  • 48
    • 47649121002 scopus 로고    scopus 로고
    • PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages
    • Ng, F., Boucher, S., Koh, S., Sastry, K. S., Chase, L., Lakshmipathy, U., et al. (2008). PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages. Blood 112, 295-307.
    • (2008) Blood , vol.112 , pp. 295-307
    • Ng, F.1    Boucher, S.2    Koh, S.3    Sastry, K.S.4    Chase, L.5    Lakshmipathy, U.6
  • 49
    • 33749661948 scopus 로고    scopus 로고
    • Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma
    • Owen, L. A., and Lessnick, S. L. (2006). Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma. Cell Cycle 5, 2049-2053.
    • (2006) Cell Cycle , vol.5 , pp. 2049-2053
    • Owen, L.A.1    Lessnick, S.L.2
  • 50
    • 0024252149 scopus 로고
    • Stromal stem cells: marrow-derived osteogenic precursors
    • Owen, M., and Friedenstein, A. J. (1988). Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found. Symp. 136, 42-60.
    • (1988) Ciba Found. Symp. , vol.136 , pp. 42-60
    • Owen, M.1    Friedenstein, A.J.2
  • 51
    • 84863011366 scopus 로고    scopus 로고
    • Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription
    • Patel, M., Simon, J. M., Iglesia, M. D., Wu, S. B., McFadden, A. W., Lieb, J. D., et al. (2012). Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription. Genome Res. 22, 259-270.
    • (2012) Genome Res. , vol.22 , pp. 259-270
    • Patel, M.1    Simon, J.M.2    Iglesia, M.D.3    Wu, S.B.4    McFadden, A.W.5    Lieb, J.D.6
  • 52
    • 78651237401 scopus 로고    scopus 로고
    • Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture
    • doi: 10.1371/journal.pone.0015689
    • Peters, R., Wolf, M. J., van den Broek, M., Nuvolone, M., Dannenmann, S., Stieger, B., et al. (2010). Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture. PLoS ONE 5:e15689. doi: 10.1371/journal.pone.0015689
    • (2010) PLoS ONE , vol.5
    • Peters, R.1    Wolf, M.J.2    van den Broek, M.3    Nuvolone, M.4    Dannenmann, S.5    Stieger, B.6
  • 54
    • 56649114486 scopus 로고    scopus 로고
    • Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors
    • Potikyan, G., France, K. A., Carlson, M. R., Dong, J., Nelson, S. F., and Denny, C. T. (2008). Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors. Lab. Invest. 88, 1291-1302.
    • (2008) Lab. Invest. , vol.88 , pp. 1291-1302
    • Potikyan, G.1    France, K.A.2    Carlson, M.R.3    Dong, J.4    Nelson, S.F.5    Denny, C.T.6
  • 55
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur, A., Tirode, F., Cohen, P., and Delattre, O. (2004). EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol. Cell. Biol. 24, 7275-7283.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 56
    • 47749084684 scopus 로고    scopus 로고
    • Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue
    • Rebelatto, C. K., Aguiar, A. M., Moretao, M. P., Senegaglia, A. C., Hansen, P., Barchiki, F., et al. (2008). Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. Exp. Biol. Med. 233, 901-913.
    • (2008) Exp. Biol. Med. , vol.233 , pp. 901-913
    • Rebelatto, C.K.1    Aguiar, A.M.2    Moretao, M.P.3    Senegaglia, A.C.4    Hansen, P.5    Barchiki, F.6
  • 57
    • 29244447707 scopus 로고    scopus 로고
    • Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells
    • Riggi, N., Cironi, L., Provero, P., Suva, M. L., Kaloulis, K., Garcia-Echeverria, C., et al. (2005). Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells. Cancer Res. 65, 11459-11468.
    • (2005) Cancer Res. , vol.65 , pp. 11459-11468
    • Riggi, N.1    Cironi, L.2    Provero, P.3    Suva, M.L.4    Kaloulis, K.5    Garcia-Echeverria, C.6
  • 58
    • 77951785861 scopus 로고    scopus 로고
    • EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells
    • Riggi, N., Suva, M. L., De Vito, C., Provero, P., Stehle, J. C., Baumer, K., et al. (2010). EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells. Genes Dev. 24, 916-932.
    • (2010) Genes Dev. , vol.24 , pp. 916-932
    • Riggi, N.1    Suva, M.L.2    De Vito, C.3    Provero, P.4    Stehle, J.C.5    Baumer, K.6
  • 59
    • 42049089299 scopus 로고    scopus 로고
    • EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells
    • Riggi, N., Suva, M. L., Suva, D., Cironi, L., Provero, P., Tercier, S., et al. (2008). EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells. Cancer Res. 68, 2176-2185.
    • (2008) Cancer Res. , vol.68 , pp. 2176-2185
    • Riggi, N.1    Suva, M.L.2    Suva, D.3    Cironi, L.4    Provero, P.5    Tercier, S.6
  • 60
    • 1242293672 scopus 로고    scopus 로고
    • The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors
    • Rorie, C. J., Thomas, V. D., Chen, P., Pierce, H. H., O'Bryan, J. P., and Weissman, B. E. (2004). The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors. Cancer Res. 64, 1266-1277.
    • (2004) Cancer Res. , vol.64 , pp. 1266-1277
    • Rorie, C.J.1    Thomas, V.D.2    Chen, P.3    Pierce, H.H.4    O'Bryan, J.P.5    Weissman, B.E.6
  • 61
    • 80054782854 scopus 로고    scopus 로고
    • Promiscuous partnerships in Ewing's sarcoma
    • Sankar, S., and Lessnick, S. L. (2011). Promiscuous partnerships in Ewing's sarcoma. Cancer Genet. 204, 351-365.
    • (2011) Cancer Genet. , vol.204 , pp. 351-365
    • Sankar, S.1    Lessnick, S.L.2
  • 62
    • 13744254666 scopus 로고    scopus 로고
    • Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors
    • Sarugaser, R., Lickorish, D., Baksh, D., Hosseini, M. M., and Davies, J. E. (2005). Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors. Stem Cells 23, 220-229.
    • (2005) Stem Cells , vol.23 , pp. 220-229
    • Sarugaser, R.1    Lickorish, D.2    Baksh, D.3    Hosseini, M.M.4    Davies, J.E.5
  • 64
    • 3042699460 scopus 로고    scopus 로고
    • Adult human mesenchymal stem cell as a target for neoplastic transformation
    • Serakinci, N., Guldberg, P., Burns, J. S., Abdallah, B., Schrodder, H., Jensen, T., et al. (2004). Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene 23, 5095-5098.
    • (2004) Oncogene , vol.23 , pp. 5095-5098
    • Serakinci, N.1    Guldberg, P.2    Burns, J.S.3    Abdallah, B.4    Schrodder, H.5    Jensen, T.6
  • 65
    • 33646366123 scopus 로고    scopus 로고
    • Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma
    • Smith, R., Owen, L. A., Trem, D. J., Wong, J. S., Whangbo, J. S., Golub, T. R., et al. (2006). Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell 9, 405-416.
    • (2006) Cancer Cell , vol.9 , pp. 405-416
    • Smith, R.1    Owen, L.A.2    Trem, D.J.3    Wong, J.S.4    Whangbo, J.S.5    Golub, T.R.6
  • 66
    • 33745266607 scopus 로고    scopus 로고
    • Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells
    • Sotiropoulou, P. A., Perez, S. A., Salagianni, M., Baxevanis, C. N., and Papamichail, M. (2006). Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. Stem Cells 24, 462-471.
    • (2006) Stem Cells , vol.24 , pp. 462-471
    • Sotiropoulou, P.A.1    Perez, S.A.2    Salagianni, M.3    Baxevanis, C.N.4    Papamichail, M.5
  • 67
    • 8544237013 scopus 로고    scopus 로고
    • DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets
    • Staege, M. S., Hutter, C., Neumann, I., Foja, S., Hattenhorst, U. E., Hansen, G., et al. (2004). DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets. Cancer Res. 64, 8213-8221.
    • (2004) Cancer Res. , vol.64 , pp. 8213-8221
    • Staege, M.S.1    Hutter, C.2    Neumann, I.3    Foja, S.4    Hattenhorst, U.E.5    Hansen, G.6
  • 68
    • 0347627149 scopus 로고    scopus 로고
    • Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells
    • Stenderup, K., Justesen, J., Clausen, C., and Kassem, M. (2003). Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone 33, 919-926.
    • (2003) Bone , vol.33 , pp. 919-926
    • Stenderup, K.1    Justesen, J.2    Clausen, C.3    Kassem, M.4
  • 70
    • 34250854663 scopus 로고    scopus 로고
    • Neuroepithelial cells supply an initial transient wave of MSC differentiation
    • Takashima, Y., Era, T., Nakao, K., Kondo, S., Kasuga, M., Smith, A. G., et al. (2007). Neuroepithelial cells supply an initial transient wave of MSC differentiation. Cell 129, 1377-1388.
    • (2007) Cell , vol.129 , pp. 1377-1388
    • Takashima, Y.1    Era, T.2    Nakao, K.3    Kondo, S.4    Kasuga, M.5    Smith, A.G.6
  • 71
    • 33744979059 scopus 로고    scopus 로고
    • Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells
    • Tamama, K., Fan, V. H., Griffith, L. G., Blair, H. C., and Wells, A. (2006). Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. Stem Cells 24, 686-695.
    • (2006) Stem Cells , vol.24 , pp. 686-695
    • Tamama, K.1    Fan, V.H.2    Griffith, L.G.3    Blair, H.C.4    Wells, A.5
  • 72
    • 14844301705 scopus 로고    scopus 로고
    • Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway
    • Terai, M., Uyama, T., Sugiki, T., Li, X. K., Umezawa, A., and Kiyono, T. (2005). Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. Mol. Biol. Cell 16, 1491-1499.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1491-1499
    • Terai, M.1    Uyama, T.2    Sugiki, T.3    Li, X.K.4    Umezawa, A.5    Kiyono, T.6
  • 73
    • 33750570283 scopus 로고    scopus 로고
    • Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells
    • Tirado, O. M., Mateo-Lozano, S., Villar, J., Dettin, L. E., Llort, A., Gallego, S., et al. (2006). Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells. Cancer Res. 66, 9937-9947.
    • (2006) Cancer Res. , vol.66 , pp. 9937-9947
    • Tirado, O.M.1    Mateo-Lozano, S.2    Villar, J.3    Dettin, L.E.4    Llort, A.5    Gallego, S.6
  • 75
    • 36048942033 scopus 로고    scopus 로고
    • EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice
    • Torchia, E. C., Boyd, K., Rehg, J. E., Qu, C., and Baker, S. J. (2007). EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol. Cell. Biol. 27, 7918-7934.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 7918-7934
    • Torchia, E.C.1    Boyd, K.2    Rehg, J.E.3    Qu, C.4    Baker, S.J.5
  • 76
    • 0037742405 scopus 로고    scopus 로고
    • Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells
    • Torchia, E. C., Jaishankar, S., and Baker, S. J. (2003). Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells. Cancer Res. 63, 3464-3468.
    • (2003) Cancer Res. , vol.63 , pp. 3464-3468
    • Torchia, E.C.1    Jaishankar, S.2    Baker, S.J.3
  • 77
    • 0036383532 scopus 로고    scopus 로고
    • Implication of maternal-cell contamination in the clinical banking of umbilical cord blood
    • Tsang, K. S., Wong, A. P., Cheung, M. S., Tang, S. H., Leung, Y., Li, C. K., et al. (2002). Implication of maternal-cell contamination in the clinical banking of umbilical cord blood. Cytotherapy 4, 375-383.
    • (2002) Cytotherapy , vol.4 , pp. 375-383
    • Tsang, K.S.1    Wong, A.P.2    Cheung, M.S.3    Tang, S.H.4    Leung, Y.5    Li, C.K.6
  • 78
    • 79955748357 scopus 로고    scopus 로고
    • Modeling initiation of Ewing sarcoma in human neural crest cells
    • doi: 10.1371/journal.pone.0019305
    • von Levetzow, C., Jiang, X., Gwye, Y., von Levetzow, G., Hung, L., Cooper, A., et al. (2011). Modeling initiation of Ewing sarcoma in human neural crest cells. PLoS ONE 6:e19305. doi: 10.1371/journal.pone.0019305
    • (2011) PLoS ONE , vol.6
    • von Levetzow, C.1    Jiang, X.2    Gwye, Y.3    von Levetzow, G.4    Hung, L.5    Cooper, A.6
  • 79
    • 27544441193 scopus 로고    scopus 로고
    • Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood
    • Wagner, W., Wein, F., Seckinger, A., Frankhauser, M., Wirkner, U., Krause, U., et al. (2005). Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp. Hematol. 33, 1402-1416.
    • (2005) Exp. Hematol. , vol.33 , pp. 1402-1416
    • Wagner, W.1    Wein, F.2    Seckinger, A.3    Frankhauser, M.4    Wirkner, U.5    Krause, U.6
  • 80
    • 67650688417 scopus 로고    scopus 로고
    • Telomerase immortalized human amnion-and adipose-derived mesenchymal stem cells: maintenance of differentiation and immunomodulatory characteristics
    • Wolbank, S., Stadler, G., Peterbauer, A., Gillich, A., Karbiener, M., Streubel, B., et al. (2009). Telomerase immortalized human amnion-and adipose-derived mesenchymal stem cells: maintenance of differentiation and immunomodulatory characteristics. Tissue Eng. Part A 15, 1843-1854.
    • (2009) Tissue Eng. Part A , vol.15 , pp. 1843-1854
    • Wolbank, S.1    Stadler, G.2    Peterbauer, A.3    Gillich, A.4    Karbiener, M.5    Streubel, B.6
  • 81
    • 33845341472 scopus 로고    scopus 로고
    • Spontaneous transformation of cultured mouse bone marrow-derived stromal cells
    • Zhou, Y. F., Bosch-Marce, M., Okuyama, H., Krishnamachary, B., Kimura, H., Zhang, L., et al. (2006). Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Res. 66, 10849-10854.
    • (2006) Cancer Res. , vol.66 , pp. 10849-10854
    • Zhou, Y.F.1    Bosch-Marce, M.2    Okuyama, H.3    Krishnamachary, B.4    Kimura, H.5    Zhang, L.6


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