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Volumn 4, Issue 5-6, 2013, Pages 213-223

EWS and RE1-Silencing Transcription Factor Inhibit Neuronal Phenotype Development and Oncogenic Transformation in Ewing Sarcoma

Author keywords

Ewing sarcoma; EWS; neuronal phenotype; oncogenic transformation; REST

Indexed keywords

NEURON RESTRICTIVE SILENCER ELEMENT; NEURON RESTRICTIVE SILENCER FACTOR; ONCOPROTEIN; UNCLASSIFIED DRUG;

EID: 84887424861     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601913489569     Document Type: Article
Times cited : (16)

References (59)
  • 1
    • 33646366123 scopus 로고    scopus 로고
    • Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma
    • Smith R,Owen LA,Trem DJ, et al.Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.Cancer Cell. 2006;9:405-16.
    • (2006) Cancer Cell , vol.9 , pp. 405-416
    • Smith, R.1    Owen, L.A.2    Trem, D.J.3
  • 2
    • 33845344030 scopus 로고    scopus 로고
    • NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma
    • Kinsey M,Smith R,Lessnick SL.NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma.Mol Cancer Res. 2006;4:851-9.
    • (2006) Mol Cancer Res , vol.4 , pp. 851-859
    • Kinsey, M.1    Smith, R.2    Lessnick, S.L.3
  • 3
    • 70450184674 scopus 로고    scopus 로고
    • GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance
    • Luo W,Gangwal K,Sankar S,Boucher KM,Thomas D,Lessnick SL.GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance.Oncogene. 2009;28:4126-32.
    • (2009) Oncogene , vol.28 , pp. 4126-4132
    • Luo, W.1    Gangwal, K.2    Sankar, S.3    Boucher, K.M.4    Thomas, D.5    Lessnick, S.L.6
  • 4
    • 0035881569 scopus 로고    scopus 로고
    • The EWS protein is dispensable for Ewing tumor growth
    • Kovar H,Jug G,Hattinger C, et al.The EWS protein is dispensable for Ewing tumor growth.Cancer Res. 2001;61:5992-7.
    • (2001) Cancer Res , vol.61 , pp. 5992-5997
    • Kovar, H.1    Jug, G.2    Hattinger, C.3
  • 5
    • 33745945163 scopus 로고    scopus 로고
    • TLS, EWS and TAF15: a model for transcriptional integration of gene expression
    • Law WJ,Cann KL,Hicks GG.TLS, EWS and TAF15: a model for transcriptional integration of gene expression.Brief Funct Genomic Proteomic. 2006;5:8-14.
    • (2006) Brief Funct Genomic Proteomic , vol.5 , pp. 8-14
    • Law, W.J.1    Cann, K.L.2    Hicks, G.G.3
  • 6
    • 79960925229 scopus 로고    scopus 로고
    • The Ewing sarcoma protein regulates DNA damage-induced alternative splicing
    • Paronetto MP,Minana B,Valcarcel J.The Ewing sarcoma protein regulates DNA damage-induced alternative splicing.Mol Cell. 2011;43:353-68.
    • (2011) Mol Cell , vol.43 , pp. 353-368
    • Paronetto, M.P.1    Minana, B.2    Valcarcel, J.3
  • 7
    • 78549288104 scopus 로고    scopus 로고
    • Cotranscriptional exon skipping in the genotoxic stress response
    • Dutertre M,Sanchez G,De Cian MC, et al.Cotranscriptional exon skipping in the genotoxic stress response.Nat Struct Mol Biol. 2010;17:1358-66.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 1358-1366
    • Dutertre, M.1    Sanchez, G.2    de Cian, M.C.3
  • 8
    • 46649093597 scopus 로고    scopus 로고
    • Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription
    • Wang X,Arai S,Song X, et al.Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.Nature. 2008;454:126-30.
    • (2008) Nature , vol.454 , pp. 126-130
    • Wang, X.1    Arai, S.2    Song, X.3
  • 9
    • 84860872161 scopus 로고    scopus 로고
    • Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels
    • Kato M,Han TW,Xie S, et al.Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.Cell. 2012;149:753-67.
    • (2012) Cell , vol.149 , pp. 753-767
    • Kato, M.1    Han, T.W.2    Xie, S.3
  • 10
    • 84866671948 scopus 로고    scopus 로고
    • Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions
    • Blechingberg J,Luo Y,Bolund L,Damgaard CK,Nielsen AL.Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions.PLoS One. 2012;7:e46251.
    • (2012) PLoS One , vol.7
    • Blechingberg, J.1    Luo, Y.2    Bolund, L.3    Damgaard, C.K.4    Nielsen, A.L.5
  • 11
    • 0242574348 scopus 로고    scopus 로고
    • Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein
    • Spahn L,Siligan C,Bachmaier R,Schmid JA,Aryee DN,Kovar H.Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein.Oncogene. 2003;22:6819-29.
    • (2003) Oncogene , vol.22 , pp. 6819-6829
    • Spahn, L.1    Siligan, C.2    Bachmaier, R.3    Schmid, J.A.4    Aryee, D.N.5    Kovar, H.6
  • 12
    • 66249118406 scopus 로고    scopus 로고
    • Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in Zebrafish embryos and human cell lines
    • Embree LJ,Azuma M,Hickstein DD.Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in Zebrafish embryos and human cell lines.Cancer Res. 2009;69:4363-71.
    • (2009) Cancer Res , vol.69 , pp. 4363-4371
    • Embree, L.J.1    Azuma, M.2    Hickstein, D.D.3
  • 13
    • 0034353182 scopus 로고    scopus 로고
    • EWS.Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing
    • Yang L,Chansky HA,Hickstein DD.EWS.Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing.J Biol Chem. 2000;275:37612-8.
    • (2000) J Biol Chem , vol.275 , pp. 37612-37618
    • Yang, L.1    Chansky, H.A.2    Hickstein, D.D.3
  • 14
    • 0023184780 scopus 로고
    • Characterization of neural cell adhesion molecules (NCAM) expressed by Ewing and neuroblastoma cell lines
    • Lipinski M,Hirsch MR,Deagostini-Bazin H,Yamada O,Tursz J,Goridis C.Characterization of neural cell adhesion molecules (NCAM) expressed by Ewing and neuroblastoma cell lines.Int J Cancer. 1987;40:81-6.
    • (1987) Int J Cancer , vol.40 , pp. 81-86
    • Lipinski, M.1    Hirsch, M.R.2    Deagostini-Bazin, H.3    Yamada, O.4    Tursz, J.5    Goridis, C.6
  • 15
    • 0023215290 scopus 로고
    • Experimental evidence for a neural origin of Ewing's sarcoma of bone
    • Cavazzana AO,Miser JS,Jefferson J,Triche TJ.Experimental evidence for a neural origin of Ewing's sarcoma of bone.Am J Pathol. 1987;127:507-18.
    • (1987) Am J Pathol , vol.127 , pp. 507-518
    • Cavazzana, A.O.1    Miser, J.S.2    Jefferson, J.3    Triche, T.J.4
  • 16
  • 17
    • 19644386697 scopus 로고    scopus 로고
    • EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors
    • Hu-Lieskovan S,Zhang J,Wu L,Shimada H,Schofield DE,Triche TJ.EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors.Cancer Res. 2005;65:4633-44.
    • (2005) Cancer Res , vol.65 , pp. 4633-4644
    • Hu-Lieskovan, S.1    Zhang, J.2    Wu, L.3    Shimada, H.4    Schofield, D.E.5    Triche, T.J.6
  • 18
    • 0021252642 scopus 로고
    • Chromosome study of Ewing's sarcoma (ES) cell lines: consistency of a reciprocal translocation t(11;22)(q24;q12)
    • Turc-Carel C,Philip I,Berger MP,Philip T,Lenoir GM.Chromosome study of Ewing's sarcoma (ES) cell lines: consistency of a reciprocal translocation t(11;22)(q24;q12).Cancer Genet Cytogenet. 1984;12:1-19.
    • (1984) Cancer Genet Cytogenet , vol.12 , pp. 1-19
    • Turc-Carel, C.1    Philip, I.2    Berger, M.P.3    Philip, T.4    Lenoir, G.M.5
  • 19
    • 0021262110 scopus 로고
    • Translocation involving chromosome 22 in Ewing's sarcoma: a cytogenetic study of four fresh tumors
    • Aurias A,Rimbaut C,Buffe D,Zucker JM,Mazabraud A.Translocation involving chromosome 22 in Ewing's sarcoma: a cytogenetic study of four fresh tumors.Cancer Genet Cytogenet. 1984;12:21-5.
    • (1984) Cancer Genet Cytogenet , vol.12 , pp. 21-25
    • Aurias, A.1    Rimbaut, C.2    Buffe, D.3    Zucker, J.M.4    Mazabraud, A.5
  • 21
    • 0033135879 scopus 로고    scopus 로고
    • Knockout of REST/NRSF shows that the protein is a potent repressor of neuronally expressed genes in non-neural tissues
    • Jones FS,Meech R.Knockout of REST/NRSF shows that the protein is a potent repressor of neuronally expressed genes in non-neural tissues.BioEssays. 1999;21:372-6.
    • (1999) BioEssays , vol.21 , pp. 372-376
    • Jones, F.S.1    Meech, R.2
  • 22
    • 33748921564 scopus 로고    scopus 로고
    • REST in good times and bad: roles in tumor suppressor and oncogenic activities
    • Majumder S.REST in good times and bad: roles in tumor suppressor and oncogenic activities.Cell Cycle. 2006;5:1929-35.
    • (2006) Cell Cycle , vol.5 , pp. 1929-1935
    • Majumder, S.1
  • 23
    • 70350126990 scopus 로고    scopus 로고
    • Regulation of non-coding RNA networks in the nervous system: what's the REST of the story?
    • Qureshi IA,Mehler MF.Regulation of non-coding RNA networks in the nervous system: what's the REST of the story?.Neurosci Lett. 2009;466:73-80.
    • (2009) Neurosci Lett , vol.466 , pp. 73-80
    • Qureshi, I.A.1    Mehler, M.F.2
  • 24
    • 20444376939 scopus 로고    scopus 로고
    • A genetic screen for candidate tumor suppressors identifies REST
    • Westbrook TF,Martin ES,Schlabach MR, et al.A genetic screen for candidate tumor suppressors identifies REST.Cell. 2005;121:837-48.
    • (2005) Cell , vol.121 , pp. 837-848
    • Westbrook, T.F.1    Martin, E.S.2    Schlabach, M.R.3
  • 25
    • 0034127794 scopus 로고    scopus 로고
    • A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker
    • Coulson JM,Edgson JL,Woll PJ,Quinn JP.A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker.Cancer Res. 2000;60:1840-4.
    • (2000) Cancer Res , vol.60 , pp. 1840-1844
    • Coulson, J.M.1    Edgson, J.L.2    Woll, P.J.3    Quinn, J.P.4
  • 26
    • 0041335557 scopus 로고    scopus 로고
    • Reduced expression of the neuron restrictive silencer factor permits transcription of glycine receptor alpha1 subunit in small-cell lung cancer cells
    • Gurrola-Diaz C,Lacroix J,Dihlmann S,Becker CM,von Knebel Doeberitz M.Reduced expression of the neuron restrictive silencer factor permits transcription of glycine receptor alpha1 subunit in small-cell lung cancer cells.Oncogene. 2003;22:5636-45.
    • (2003) Oncogene , vol.22 , pp. 5636-5645
    • Gurrola-Diaz, C.1    Lacroix, J.2    Dihlmann, S.3    Becker, C.M.4    von Knebel Doeberitz, M.5
  • 27
    • 15944374306 scopus 로고    scopus 로고
    • Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16
    • Fuller GN,Su X,Price RE, et al.Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16.Mol Cancer Ther. 2005;4:343-9.
    • (2005) Mol Cancer Ther , vol.4 , pp. 343-349
    • Fuller, G.N.1    Su, X.2    Price, R.E.3
  • 30
    • 78651240858 scopus 로고    scopus 로고
    • Chromogranin A: serum marker for prostate cancer
    • Khan MO,Ather MH.Chromogranin A: serum marker for prostate cancer.J Pak Med Assoc. 2011;61:108-11.
    • (2011) J Pak Med Assoc , vol.61 , pp. 108-111
    • Khan, M.O.1    Ather, M.H.2
  • 31
    • 0031033247 scopus 로고    scopus 로고
    • Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the rat CNS
    • Berton F,Iborra C,Boudier JA,Seagar MJ,Marqueze B.Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the rat CNS.J Neurosci. 1997;17:1206-16.
    • (1997) J Neurosci , vol.17 , pp. 1206-1216
    • Berton, F.1    Iborra, C.2    Boudier, J.A.3    Seagar, M.J.4    Marqueze, B.5
  • 32
    • 0001398513 scopus 로고    scopus 로고
    • Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance
    • Hahm S,Mizuno TM,Wu TJ, et al.Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance.Neuron. 1999;23:537-48.
    • (1999) Neuron , vol.23 , pp. 537-548
    • Hahm, S.1    Mizuno, T.M.2    Wu, T.J.3
  • 33
    • 0344629700 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity
    • Alder J,Thakker-Varia S,Bangasser DA, et al.Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity.J Neurosci. 2003;23:10800-8.
    • (2003) J Neurosci , vol.23 , pp. 10800-10808
    • Alder, J.1    Thakker-Varia, S.2    Bangasser, D.A.3
  • 34
    • 84867704444 scopus 로고    scopus 로고
    • Dysregulated expression of secretogranin III is involved in neurotoxin-induced dopaminergic neuron apoptosis
    • Li F,Tian X,Zhou Y, et al.Dysregulated expression of secretogranin III is involved in neurotoxin-induced dopaminergic neuron apoptosis.J Neurosci Res. 2012;90:2237-46.
    • (2012) J Neurosci Res , vol.90 , pp. 2237-2246
    • Li, F.1    Tian, X.2    Zhou, Y.3
  • 35
    • 0010394995 scopus 로고    scopus 로고
    • Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains
    • Perletti L,Talarico D,Trecca D, et al.Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains.Genomics. 1997;46:251-9.
    • (1997) Genomics , vol.46 , pp. 251-259
    • Perletti, L.1    Talarico, D.2    Trecca, D.3
  • 36
    • 0034007505 scopus 로고    scopus 로고
    • Elevated serum chromogranin A is detectable in patients with carcinomas at advanced disease stages
    • Wu JT,Erickson AJ,Tsao KC,Wu TL,Sun CF.Elevated serum chromogranin A is detectable in patients with carcinomas at advanced disease stages.Ann Clin Lab Sci. 2000;30:175-8.
    • (2000) Ann Clin Lab Sci , vol.30 , pp. 175-178
    • Wu, J.T.1    Erickson, A.J.2    Tsao, K.C.3    Wu, T.L.4    Sun, C.F.5
  • 37
    • 58849115512 scopus 로고    scopus 로고
    • SCG3 transcript in peripheral blood is a prognostic biomarker for REST-deficient small cell lung cancer
    • Moss AC,Jacobson GM,Walker LE,Blake NW,Marshall E,Coulson JM.SCG3 transcript in peripheral blood is a prognostic biomarker for REST-deficient small cell lung cancer.Clin Cancer Res. 2009;15:274-83.
    • (2009) Clin Cancer Res , vol.15 , pp. 274-283
    • Moss, A.C.1    Jacobson, G.M.2    Walker, L.E.3    Blake, N.W.4    Marshall, E.5    Coulson, J.M.6
  • 38
    • 76649105782 scopus 로고    scopus 로고
    • A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis
    • Matsumoto T,Kawashima Y,Nagashio R, et al.A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis.Int J Biol Markers. 2009;24:282-5.
    • (2009) Int J Biol Markers , vol.24 , pp. 282-285
    • Matsumoto, T.1    Kawashima, Y.2    Nagashio, R.3
  • 39
    • 0029796093 scopus 로고    scopus 로고
    • Identification of potential target genes for the neuron-restrictive silencer factor
    • Schoenherr CJ,Paquette AJ,Anderson DJ.Identification of potential target genes for the neuron-restrictive silencer factor.Proc Natl Acad Sci U S A. 1996;93:9881-6.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9881-9886
    • Schoenherr, C.J.1    Paquette, A.J.2    Anderson, D.J.3
  • 40
    • 34250815056 scopus 로고    scopus 로고
    • A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions
    • Otto SJ,McCorkle SR,Hover J, et al.A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions.J Neurosci. 2007;27:6729-39.
    • (2007) J Neurosci , vol.27 , pp. 6729-6739
    • Otto, S.J.1    McCorkle, S.R.2    Hover, J.3
  • 41
    • 65549095495 scopus 로고    scopus 로고
    • REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells
    • Jørgensen HF,Terry A,Beretta C, et al.REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells.Development. 2009;136:715-21.
    • (2009) Development , vol.136 , pp. 715-721
    • Jørgensen, H.F.1    Terry, A.2    Beretta, C.3
  • 42
    • 0031935157 scopus 로고    scopus 로고
    • EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes
    • Bertolotti A,Melot T,Acker J,Vigneron M,Delattre O,Tora L.EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes.Mol Cell Biol. 1998;18:1489-97.
    • (1998) Mol Cell Biol , vol.18 , pp. 1489-1497
    • Bertolotti, A.1    Melot, T.2    Acker, J.3    Vigneron, M.4    Delattre, O.5    Tora, L.6
  • 43
    • 1842843228 scopus 로고    scopus 로고
    • The pro-oncoprotein EWS (Ewing's sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription
    • Thomas GR,Latchman DS.The pro-oncoprotein EWS (Ewing's sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription.Cancer Biol Ther. 2002;1:428-32.
    • (2002) Cancer Biol Ther , vol.1 , pp. 428-432
    • Thomas, G.R.1    Latchman, D.S.2
  • 44
    • 79960007644 scopus 로고    scopus 로고
    • The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells
    • Gao Z,Ure K,Ding P, et al.The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells.J Neurosci1999. 2011;31:9772-86.
    • (2011) J Neurosci1999 , vol.31 , pp. 9772-9786
    • Gao, Z.1    Ure, K.2    Ding, P.3
  • 45
    • 84863011366 scopus 로고    scopus 로고
    • Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription
    • Patel M,Simon JM,Iglesia MD, et al.Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription.Genome Res. 2012;22:259-70.
    • (2012) Genome Res , vol.22 , pp. 259-270
    • Patel, M.1    Simon, J.M.2    Iglesia, M.D.3
  • 46
    • 79960614727 scopus 로고    scopus 로고
    • ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions
    • Rashid NU,Giresi PG,Ibrahim JG,Sun W,Lieb JD.ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions.Genome Biol. 2011;12:R67.
    • (2011) Genome Biol , vol.12
    • Rashid, N.U.1    Giresi, P.G.2    Ibrahim, J.G.3    Sun, W.4    Lieb, J.D.5
  • 47
    • 77949771793 scopus 로고    scopus 로고
    • CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis
    • Rocchi A,Manara MC,Sciandra M, et al.CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis.J Clin Invest. 2010;120:668-80.
    • (2010) J Clin Invest , vol.120 , pp. 668-680
    • Rocchi, A.1    Manara, M.C.2    Sciandra, M.3
  • 48
    • 43149105398 scopus 로고    scopus 로고
    • Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer
    • Sanchez G,Bittencourt D,Laud K, et al.Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer.Proc Natl Acad Sci U S A. 2008;105:6004-9.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 6004-6009
    • Sanchez, G.1    Bittencourt, D.2    Laud, K.3
  • 49
    • 84886093785 scopus 로고    scopus 로고
    • Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma
    • Sankar S,Bell R,Stephens B, et al.Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.Oncogene. 2012;:.
    • (2012) Oncogene
    • Sankar, S.1    Bell, R.2    Stephens, B.3
  • 50
    • 0345451010 scopus 로고    scopus 로고
    • Desmoplastic small round cell tumor, I: a histopathologic study of 39 cases with emphasis on unusual histological patterns
    • Ordonez NG.Desmoplastic small round cell tumor, I: a histopathologic study of 39 cases with emphasis on unusual histological patterns.Am J Surg Pathol. 1998;22:1303-13.
    • (1998) Am J Surg Pathol , vol.22 , pp. 1303-1313
    • Ordonez, N.G.1
  • 51
    • 0035569282 scopus 로고    scopus 로고
    • Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation
    • Goh YW,Spagnolo DV,Platten M, et al.Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation.Histopathology. 2001;39:514-24.
    • (2001) Histopathology , vol.39 , pp. 514-524
    • Goh, Y.W.1    Spagnolo, D.V.2    Platten, M.3
  • 52
    • 77954572735 scopus 로고    scopus 로고
    • Long noncoding RNA as modular scaffold of histone modification complexes
    • Tsai MC,Manor O,Wan Y, et al.Long noncoding RNA as modular scaffold of histone modification complexes.Science. 2010;329:689-93.
    • (2010) Science , vol.329 , pp. 689-693
    • Tsai, M.C.1    Manor, O.2    Wan, Y.3
  • 53
    • 84857710881 scopus 로고    scopus 로고
    • PRAS40 is a functionally critical target for EWS repression in Ewing sarcoma
    • Huang L,Nakai Y,Kuwahara I,Matsumoto K.PRAS40 is a functionally critical target for EWS repression in Ewing sarcoma.Cancer Res. 2012;72:1260-9.
    • (2012) Cancer Res , vol.72 , pp. 1260-1269
    • Huang, L.1    Nakai, Y.2    Kuwahara, I.3    Matsumoto, K.4
  • 54
    • 19344378845 scopus 로고    scopus 로고
    • IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation
    • Tawadros T,Martin D,Abderrahmani A,Leisinger HJ,Waeber G,Haefliger JA.IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation.Cell Signal. 2005;17:929-39.
    • (2005) Cell Signal , vol.17 , pp. 929-939
    • Tawadros, T.1    Martin, D.2    Abderrahmani, A.3    Leisinger, H.J.4    Waeber, G.5    Haefliger, J.A.6
  • 55
    • 12844250536 scopus 로고    scopus 로고
    • Small CTD phosphatases function in silencing neuronal gene expression
    • Yeo M,Lee SK,Lee B,Ruiz EC,Pfaff SL,Gill GN.Small CTD phosphatases function in silencing neuronal gene expression.Science. 2005;307:596-600.
    • (2005) Science , vol.307 , pp. 596-600
    • Yeo, M.1    Lee, S.K.2    Lee, B.3    Ruiz, E.C.4    Pfaff, S.L.5    Gill, G.N.6
  • 56
    • 0036560740 scopus 로고    scopus 로고
    • The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
    • Lessnick SL,Dacwag CS,Golub TR.The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts.Cancer Cell. 2002;1:393-401.
    • (2002) Cancer Cell , vol.1 , pp. 393-401
    • Lessnick, S.L.1    Dacwag, C.S.2    Golub, T.R.3
  • 57
    • 0028821578 scopus 로고
    • Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene
    • Lessnick SL,Braun BS,Denny CT,May WA.Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene.Oncogene. 1995;10:423-31.
    • (1995) Oncogene , vol.10 , pp. 423-431
    • Lessnick, S.L.1    Braun, B.S.2    Denny, C.T.3    May, W.A.4
  • 58
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A,Tamayo P,Mootha VK, et al.Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Proc Natl Acad Sci U S A. 2005;102:15545-50.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 59
    • 84855170482 scopus 로고    scopus 로고
    • MotifMap: integrative genome-wide maps of regulatory motif sites for model species
    • Daily K,Patel VR,Rigor P,Xie X,Baldi P.MotifMap: integrative genome-wide maps of regulatory motif sites for model species.BMC Bioinformatics. 2011;12:495.
    • (2011) BMC Bioinformatics , vol.12 , pp. 495
    • Daily, K.1    Patel, V.R.2    Rigor, P.3    Xie, X.4    Baldi, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.