Recent advances in cortisol sensing technologies for point-of-care application

Biosensors and Bioelectronics

Volumn 53, Issue , 2014, Pages 499-512

  Kaushik, Ajeet ^a   Vasudev, Abhay ^a   Arya, Sunil K ^b   Pasha, Syed Khalid ^a   Bhansali, Shekhar ^a  

^a Florida International University   (United States)

^b INSTITUTE OF MICROELECTRONICS   (Singapore)

Author keywords

Cortisol; Electrochemical immunosensing; Immunoassays; Point of care (POC); Psychological stress

Indexed keywords

CENTRAL NERVOUS SYSTEMS; CHROMATOGRAPHIC TECHNIQUES; ELECTROCHEMICAL IMMUNOSENSING; IMMUNOASSAYS; MULTISTEP EXTRACTIONS; PERSONALIZED HEALTHCARE; POINT OF CARE; PSYCHOLOGICAL STRESS;

BIOMARKERS; HEALTH CARE; MICROELECTRODES; PHYSIOLOGY; SENSORS; WEARABLE COMPUTERS;

CORTISOL;

BIOLOGICAL MARKER; HYDROCORTISONE;

BIOSENSOR; CHROMATOGRAPHY; ELECTROCHEMICAL ANALYSIS; ELECTROCHEMICAL IMMUNOSENSING; HAIR ANALYSIS; HORMONE DETERMINATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYDROCORTISONE URINE LEVEL; IMMUNOASSAY; IMMUNOSENSOR; INTERSTITIAL FLUID; PHYSIOLOGICAL STRESS; POINT OF CARE TESTING; REMOTE SENSING; REVIEW; SALIVA ANALYSIS; SWEAT TEST;

CORTISOL; ELECTROCHEMICAL IMMUNOSENSING; IMMUNOASSAYS; POINT-OF-CARE (POC); PSYCHOLOGICAL STRESS;

BIOSENSING TECHNIQUES; HUMANS; HYDROCORTISONE; IMMUNOASSAY; INDIVIDUALIZED MEDICINE; MICROFLUIDICS; POINT-OF-CARE SYSTEMS;

EID: 84887398488     PISSN: 09565663     EISSN: 18734235     Source Type: Journal    
DOI: 10.1016/j.bios.2013.09.060     Document Type: Review

References (114)

1. Abraham G.E., Buster J.E., Teller R.C. Radioimmunoassay of plasma cortisol. Anal. Lett. 1972, 5(11):757-765.
2. Ahn C.H., Choi J.-W., Beaucage G., Nevin J.H., Lee J.-B., Puntambekar A., Lee J.Y. Disposable smart lab on a chip for point-of-care clinical diagnostics. Proc. IEEE 2004, 92(1):154-173.
3. Appel D., Schmid R.D., Dragan C.-A., Bureik M., Urlacher V.B. A fluorimetric assay for cortisol. Anal. Bioanal. Chem. 2005, 383(2):182-186.
4. Arya S.K., Chornokur G., Venugopal M., Bhansali S. Antibody functionalized interdigitated μ-electrode (IDμE) based impedimetric cortisol biosensor. Analyst 2010, 135(8):1941.
5. Arya S.K., Chornokur G., Venugopal M., Bhansali S. Antibody modified gold micro array electrode based electrochemical immunosensor for ultrasensitive detection of cortisol in saliva and ISF. Proc. Eng. 2010, 5:804-807.
6. Arya S.K., Chornokur G., Venugopal M., Bhansali S. Dithiobis(succinimidyl propionate) modified gold microarray electrode based electrochemical immunosensor for ultrasensitive detection of cortisol. Biosens. Bioelectron. 2010, 25(10):2296-2301.
7. Arya S.K., Dey A., Bhansali S. Polyaniline protected gold nanoparticles based mediator and label free electrochemical cortisol biosensor. Biosens. Bioelectron. 2011, 28(1):166-173.
8. Atashbar M.Z., Bejcek B., Vijh A., Singamaneni S. QCM biosensor with ultra thin polymer film. Sensors Actuators B: Chem. 2005, 107(2):945-951.
9. Attili B.S., Suleiman A.A. A piezoelectric immunosensor for the detection of cortisol. Anal. Lett. 1995, 28(12):2149-2159.
10. Belaya Z.E., Iljin A.V., Melnichenko G.A., Rozhinskaya L.Y., Dragunova N.V., Dzeranova L.K., Butrova S.A., Troshina E.A., Dedov I.I. Diagnostic performance of late-night salivary cortisol measured by automated electrochemiluminescence immunoassay in obese and overweight patients referred to exclude Cushing's syndrome. Endocrine 2012, 41(3):494-500.
11. Bennett A., Hayssen V. Hair as a biological indicator of drug use, drug abuse or chronic exposure to environmental toxicants. Int. J. Toxicol. 2006, 25:143-163.
12. Brezina P.R., Haberl E., Wallach E. At home testing: optimizing management for the infertility physician. Fertil. Steril. 2011, 95(6):1867-1878.
13. Brossaud J., Ducint D., Gatta B., Molimard M., Tabarin A., Corcuff J. Urinary cortisol metabolites in corticotroph and adrenal tumours. Endocr. Abstr. 2012, P55. http://www.endocrine-abstracts.org/ea/0029/ea0029p55.htm.
14. Carpenter L.L., Shattuck T.T., Tyrka A.R., Geracioti T.D., Price L.H. Effect of childhood physical abuse on cortisol stress response. Psychopharmacology (Berl.) 2011, 214(1):367-375.
15. Carrozza C., Corsello S.M., Paragliola R.M., Ingraudo F., Palumbo S., Locantore P., Sferrazza A., Pontecorvi A., Zuppi C. Clinical accuracy of midnight salivary cortisol measured by automated electrochemiluminescence immunoassay method in Cushing's syndrome. Ann. Clin. Biochem. 2010, 47(3):228-232.
16. Chan C.P.Y., Mak W.C., Cheung K.Y., Sin K.K., Yu C.M., Rainer T.H., Renneberg R. Evidence-based point-of-care diagnostics: current status and emerging technologies. Annu. Rev. Anal. Chem. 2013, 6(1):191-211.
17. Chantasirichot S., Ishihara K. Electrospun phospholipid polymer substrate for enhanced performance in immunoassay system. Biosens. Bioelectron. 2012, 38(1):209-214.
18. Chen L.-Q., Kang X.-J., Sun J., Deng J.-J., Gu Z.-Z., Lu Z.-H. Application of nanofiber-packed SPE for determination of salivary-free cortisol using fluorescence precolumn derivatization and HPLC detection. J. Sep. Sci. 2010, 33(15):2369-2375.
19. Cooper M.A. Label-free screening of bio-molecular interactions. Anal. Bioanal. Chem. 2003, 377(5):834-842.
20. Corbalan-Tutau M.D., Madrid J.A., Nicolas F., Garaulet M. Daily profile in two circadian markers "melatonin and cortisol" and associations with metabolic syndrome components. Physiol. Behav 2012.
21. Czeisler C.A., Ede M.C.M., Regestein Q.R., Kosch E.S., Fang V.S., Ehrlich E.N. Episodic 24-hour cortisol secretory patterns in patients awaiting elective cardiac surgery. J. Clin. Endocrinol. Metabol. 1976, 42(2):273-283.
22. Dash R., England B.G., Midgley A.R., Niswender G.D. A specific, non-chromatographic radioimmunoassay for human plasma cortisol. Steroids 1975, 26(5):647-661.
23. Delahanty D.L., Raimonde A.J., Spoonster E. Initial posttraumatic urinary cortisol levels predict subsequent PTSD symptoms in motor vehicle accident victims. Biol. Psychiatry 2000, 48(9):940-947.
24. Djuric Z., Bird C.E., Furumoto-Dawson A., Rauscher G.H., Ruffin Iv M.T., Stowe R.P., Tucker K.L., Masi C.M. Biomarkers of psychological stress in health disparities research. Open Biomark. J. 2008, 1(1):7-19.
25. Dobson H., Smith R.F. What is stress, and how does it affect reproduction?. Anim. Reproduct. Sci. 2000, 60 and 61(0):743-752.
26. de Kloet E.R., M.J., Holsboer Florian Stress and the brain: from adaptation to disease. Nature Rev. Neurosci. 2005, 6(6):13.
27. Edwards O., Galley J.M., Courtenay-Evans R.J., Hunter J., Tait A. Changes in cortisol metabolism following rifampicin therapy. Lancet 1974, 304(7880):549-551.
28. El-Laboudi A., Oliver N.S., Cass A., Johnston D. Use of microneedle array devices for continuous glucose monitoring: a review. Diabetes Technol. Ther. 2013, 15(1):101-115.
29. Frasconi M., Mazzarino M., Botrè F., Mazzei F. Surface plasmon resonance immunosensor for cortisol and cortisone determination. Anal. Bioanal. Chem. 2009, 394(8):2151-2159.
30. Fulford R., Stone G. Dr. Fulford's Touch of Life: The Healing Power of the Natural Life Force 1997, Gallery Books.
31. Funk W., Kerler R., Boll E., Dammann V. High-performance thin-layer chromatographic determination of fluorescence-labelled cortisol. J. Chromatogr. A 1981, 217(0):349-355.
32. Gao W., Xie Q., Jin J., Qiao T., Wang H., Chen L., Deng H., Lu Z. HPLC-FLU detection of cortisol distribution in human hair. Clin. Biochem. 2010, 43(7 and 8):677-682.
33. Gatti R., Antonelli G., Prearo M., Spinella P., Cappellin E., De Palo E.F. Cortisol assays and diagnostic laboratory procedures in human biological fluids. Clin. Biochem. 2009, 42(12):1205-1217.
34. Glaros C., Fotiadis D. Wearable devices in healthcare. Intelligent Paradigms for Healthcare Enterprises 2005, 237-264. Springer, Berlin, Heidelberg. B. Silverman, A. Jain, A. Ichalkaranje, L. Jain (Eds.).
35. Goldman E.R., Anderson G.P., Conway J., Sherwood L.J., Fech M., Vo B., Liu J.L., Hayhurst A. Thermostable Llama single domain antibodies for detection of botulinum a neurotoxin complex. Anal. Chem. 2008, 80(22):8583-8591.
36. Gomez-Sanchez C., Milewich L., Holland O.B. Radioiodinated derivatives for steroid radioimmunoassay. Application to the radioimmunoassay of cortisol. J. Lab. Clin. Med. (United States) 1977, 89:4.
37. Gow R., Thomson S., Reider M., Van Uum S., Koren G. An assessment of cortisol analysis in hair and its clinical applications. Forensic Sci. Int. 2010, 196(1-3):32-37.
38. Granger, A., Henry, A., Lilliencrantz, L., Smith, A., Srnis, P., Van Schepen, W., Injeti, E., 2012. Effects of Physical Stress and Maturational Changes on Hypothalamic Pituitary Adrenal Axis Function Through Cortisol Analysis. http://works.bepress.com/elisha_injeti/4/.
39. Holsboer F., Ising M. Stress hormone regulation: biological role and translation into therapy. Annu. Rev. Psychol. 2010, 61:81-109.
40. Hung, K., Zhang, Y.T., Tai, B., 2004. Wearable medical devices for tele-home healthcare. In: Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE, pp. 5384-5387.
41. Jia M., He Z., Jin W. Capillary electrophoretic enzyme immunoassay with electrochemical detection for cortisol. J. Chromatogr. A 2002, 966(1 and 2):187-194.
42. Kabra P.M., Tsai L.L., Marton L.J. Improved liquid-chromatographic method for determination of serum cortisol. Clin. Chem. 1979, 25(7):1293-1296.
43. Kalra S., Einarson A., Karaskov T., van Uum S., Koren G. The relationship between stress and hair cortisol in healthy pregnant women. Clin. Invest. Med. 2007, 30(2):103-107.
44. Kao M., Voina S., Nichols A., Horton R. Parallel radioimmunoassay for plasma cortisol and 11-deoxycortisol. Clin. Chem. 1975, 21(11):1644-1647.
45. Kaushik A., Vasudev A., Arya S.K., Bhansali S. Mediator and label free estimation of stress biomarker using electrophoretically deposited Ag@AgO-polyaniline hybrid nanocomposite. Biosens. Bioelectron. 2013, 50(0):35-41.
46. Khanna P., Strom J.A., Malone J.I., Bhansali S. Microneedle-based automated therapy for diabetes mellitus. J. Diabetes Sci. Technol. 2008, 2(6):1122-1129.
47. Kim S.B., Takenaka Y., Torimura M. A bioluminescent probe for salivary cortisol. Bioconjug. Chem. 2011, 22(9):1835-1841.
48. Klopfenstein B.J., Purnell J.Q., Brandon D.D., Isabelle L.M., DeBarber A.E. Determination of cortisol production rates with contemporary liquid chromatography-mass spectrometry to measure cortisol-d3 dilution after infusion of deuterated tracer. Clin. Biochem. 2011, 44(5 and 6):430-434.
49. Kobayashi Y., Amitani K., Watanabe F., Miyai K. Fluorescence polarization immunoassay for cortisol. Clin. Chim. Acta 1979, 92(2):241-247.
50. Koren L., Mokady O., Karaskov T., Klein J., Koren G., Geffen E. A novel method using hair for determining hormonal levels in wildlife. Anim. Behav. 2002, 63(2):403-406.
51. Koutny L.B., Schmalzing D., Taylor T.A., Fuchs M. Microchip electrophoretic immunoassay for serum cortisol. Anal. Chem. 1996, 68(1):18-22.
52. Krischbaum C., Tietze A., Skoluda N., Dettenborn L. Hair as a retrospective calendar of cortisol production: increased cortisol incorporation into hair in the third trimester of pregnancy. Psychoneuroendocrinology 2009, 34(1):32-37.
53. Kumar A., Aravamudhan S., Gordic M., Bhansali S., Mohapatra S.S. Ultrasensitive detection of cortisol with enzyme fragment complementation technology using functionalized nanowire. Biosens. Bioelectron. 2007, 22(9 and 10):2138-2144.
54. Le Roux C.W., Chapman G., Kong W., Dhillo W., Jones J., Alaghband-Zadeh J. Free cortisol index is better than serum total cortisol in determining hypothalamic-pituitary-adrenal status in patients undergoing surgery. J. Clin. Endocrinol. Metabol. 2003, 88(5):2045-2048.
55. Levine A., Zagoory-Sharon O., Feldman R., Lewis J.G., Weller A. Measuring cortisol in human psychobiological studies. Physiol. Behav. 2007, 90(1):43-53.
56. Lewis J., Elder P. An enzyme-linked immunosorbent assay (ELISA) for plasma cortisol. J. Steroid. Biochem. 1985, 22(5):673-676.
57. Lillehoj P.B., Huang M.-C., Truong N., Ho C.-M. Rapid electrochemical detection on a mobile phone. Lab. Chip. 2013, 13(15):2950-2955.
58. Lippi G., De Vita F., Salvagno G.L., Gelati M., Montagnana M., Guidi G.C. Measurement of morning saliva cortisol in athletes. Clin. Biochem. 2009, 42(9):904-906.
59. Loncaric C., Tang Y., Ho C., Parameswaran M.A., Yu H.-Z. A USB-based electrochemical biosensor prototype for point-of-care diagnosis. Sensors Actuators B: Chem. 2012, 161(1):908-913.
60. Lovas K., Thorsen T., Husebye E. Saliva cortisol measurement: simple and reliable assessment of the glucocorticoid replacement therapy in Addison's disease. J. Endocrinol. Invest. 2006, 29(8):727.
61. Manenschijn L., Koper J.W., Lamberts S.W.J., van Rossum E.F.C. Evaluation of a method to measure long term cortisol levels. Steroids 2011, 76(10 and 11):1032-1036.
62. McEwen B.S. Cortisol, Cushing's syndrome, and a shrinking brain-new evidence for reversibility. J. Clin. Endocrinol. Metabol. 2002, 87(5):1947-1948.
63. McRae A.L., Saladin M.E., Brady K.T., Upadhyaya H., Back S.E., Timmerman M.A. Stress reactivity: biological and subjective responses to the cold pressor and Trier social stressors. Human Psychopharmacol.: Clin. Exp. 2006, 21(6):377-385.
64. Mitchell J.S., Lowe T.E., Ingram J.R. Rapid ultrasensitive measurement of salivary cortisol using nano-linker chemistry coupled with surface plasmon resonance detection. Analyst 2008, 134(2):380-386.
65. Mitchell J.S., Lowe T.E., Ingram J.R. Rapid ultrasensitive measurement of salivary cortisol using nano-linker chemistry coupled with surface plasmon resonance detection. Analyst (Lond.) 2009, 134(2):380.
66. Moreno-Guzman M., Eguilaz M., Campuzano S., Gonzalez-Cortes A., Yanez-Sedeno P., Pingarron J.M. Disposable immunosensor for cortisol using functionalized magnetic particles. Analyst (Lond.) 2010, 135(8):1926.
67. Mukerjee E.V., Collins S.D., Isseroff R.R., Smith R.L. Microneedle array for transdermal biological fluid extraction and in situ analysis. Sensors Actuat. A: Phys. 2004, 114(2 and 3):267-275.
68. Nicolson, N.A., 2008. Measurement of Cortisol, Handbook of Physiological Research Methods in Health Psychology, Sage Publications, Inc., pp. 37-74.
69. Pervanidou P., Kolaitis G., Charitaki S., Lazaropoulou C., Papassotiriou I., Hindmarsh P., Bakoula C., Tsiantis J., Chrousos G.P. The natural history of neuroendocrine changes in pediatric posttraumatic stress disorder (PTSD) after motor vehicle accidents: progressive divergence of noradrenaline and cortisol concentrations over time. Biol. Psychiatry 2007, 62(10):1095-1102.
70. Petkus M.M., McLauchlin M., Vuppu A.K., Rios L., Garcia A.A., Hayes M.A. Detection of FITC-cortisol via modulated supraparticle lighthouses. Anal. Chem. 2006, 78(5):1405-1411.
71. Prausnitz M.R. Microneedles for transdermal drug delivery. Adv. Drug. Deliv. Rev. 2004, 56(5):581-587.
72. Price C.P., Kricka L.J. Improving healthcare accessibility through point-of-care technologies. Clin. Chem. 2007, 53(9):1665-1675.
73. Price D., Close G., Fielding B. Age of appearance of circadian rhythm in salivary cortisol values in infancy. Arch. Dis. Child. 1983, 58(6):454-456.
74. Prunty H., Andrews K., Reddy-Kolanu G., Quinlan P., Wood P. Sweat patch cortisol-a new screen for Cushing's syndrome. Endocr. Abstr. 2004, P202.
75. Raff H., Raff J.L., Findling J.W. Late-night salivary cortisol as a screening test for Cushing's syndrome. J. Clin. Endocrinol. Metabol. 1998, 83(8):2681-2686.
76. Raul J.-S., Cirimele V., Ludes B., Kintz P. Detection of physiological concentrations of cortisol and cortisone in human hair. Clin. Biochem. 2004, 37(12):1105-1111.
77. Ricci F., Adornetto G., Palleschi G. A review of experimental aspects of electrochemical immunosensors. Electrochim. Acta 2012, 84(0):74-83.
78. Ruder H.J., Guy R.L., Lipsett M.B. A radioimmunoassay for cortisol in plasma and urine. J. Clin. Endocrinol. Metabol. 1972, 35(2):219-224.
79. Russell E., Koren G., Reider M., Van Uum S. The detection of cortisol in human sweat: implications for measurement of cortisol in hair. Endocr. Rev. 2012, 33:03.
80. Russell E., Koren G., Rieder M., Van Uum S. Hair cortisol as a biological marker of chronic stress: current status, future directions and unanswered questions. Psychoneuroendocrinology 2012, 37(5):589-601.
81. Sauve B., Koren G., Walsh G., Tokmakejian S., Van Uum S. Measurement of cortisol in human hair as a biomarker of systemic exposure. Clin. Invest. Med. 2007, 30(5):83-91.
82. Schmalzing D., Nashabeh W., Yao X.-W., Mhatre R., Regnier F.E., Afeyan N.B., Fuchs M. Capillary electrophoresis-based immunoassay for cortisol in serum. Anal. Chem. 1995, 67(3):606-612.
83. Shankaran D.R., Gobi K.V., Miura N. Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical, food and environmental interest. Sensors Actuators B: Chem. 2007, 121(1):158-177.
84. Shi H., Xu X., Ding Y., Liu S., Li L., Kang W. Determination of cortisol in human blood sera by a new Ag(III) complex-luminol chemiluminescent system. Anal. Biochem. 2009, 387(2):178-183.
85. Shimada M., Takahashi K., Ohkawa T., Segawa M., Higurashi M. Determination of salivary cortisol by ELISA and its application to the assessment of the circadian rhythm in children. Horm. Res. Paediatr. 1995, 44(5):213-217.
86. Small B.C., Davis K.B. Validation of a time-resolved fluoroimmunoassay for measuring plasma cortisol in channel catfish Ictalurus punctatus. J. World Aquac. Soc. 2007, 33(2):184-187.
87. Soper S.A., Brown K., Ellington A., Frazier B., Garcia-Manero G., Gau V., Gutman S.I., Hayes D.F., Korte B., Landers J.L. Point-of-care biosensor systems for cancer diagnostics/prognostics. Biosens. Bioelectron. 2006, 21(10):1932-1942.
88. Stalder T., Steudte S., Alexander N., Miller R., Gao W., Dettenborn L., Kirschbaum C. Cortisol in hair, body mass index and stress-related measures. Biol. Psychol. 2012, 90(3):218-223.
89. Stevens R.C., Soelberg S.D., Near S., Furlong C.E. Detection of cortisol in saliva with a flow-filtered, portable surface plasmon resonance biosensor system. Anal. Chem. 2008, 80(17):6747-6751.
90. Sun K., Ramgir N., Bhansali S. An immunoelectrochemical sensor for salivary cortisol measurement. Sensors Actuators B: Chem. 2008, 133(2):533-537.
91. Teruhisa U., Ryoji H., Taisuke I., Tatsuya S., Fumihiro M., Tatsuo S. Use of saliva for monitoring unbound free cortisol levels in serum. Clin. Chim. Acta 1981, 110(2):245-253.
92. Tilden R. New, advantageous approach to the direct radioimmunoassay of cortisol. Clin. Chem. 1977, 23(2):211-215.
93. Tlili C., Myung N.V., Shetty V., Mulchandani A. Label-free, chemiresistor immunosensor for stress biomarker cortisol in saliva. Biosens. Bioelectron. 2011, 26(11):4382-4386.
94. Turner A.P.F. Biosensors: sense and sensibility. Chem. Soc. Rev. 2013, 42(8):3184-3196.
95. Turpeinen U., Markkanen H., Välimäki M., Stenman U.-H. Determination of urinary free cortisol by HPLC. Clin. Chem. 1997, 43(8):1386-1391.
96. van Aken M.O., Romijn J.A., Miltenburg J.A., Lentjes E.G.W.M. Automated measurement of salivary cortisol. Clin. Chem. 2003, 49(8):1408-1409.
97. Van Caenegem E., Wierckx K., Fiers T., Segers H., Vandersypt E., Kaufman J., T'Sjoen G. Salivary cortisol and testosterone: a comparison of salivary sample collection methods in healthy controls. Endocr. Abstr. 2011, P355.
98. VanBruggen M., Hackney A., McMurray R., Ondrak K. The relationship between serum and salivary cortisol levels in response to different intensities of exercise. Int. J. Sports Physiol. Perform. 2011, 6(3):396.
99. Vasudev A., Kaushik A., Tomizawa Y., Norena N., Bhansali S. An LTCC-based microfluidic system for label-free, electrochemical detection of cortisol. Sensors Actuators B: Chem. 2013, 182(0):139-146.
100. Venugopal M., Arya S.K., Chornokur G., Bhansali S. A realtime and continuous assessment of cortisol in ISF using electrochemical impedance spectroscopy. Sensors Actuators A: Phys. 2011, 172(1):154-160.
101. Venugopal M., Feuvrel K.E., Mongin D., Bambot S., Faupel M., Panangadan A., Talukder A., Pidva R. Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring. Sensors J. IEEE 2008, 8(1):71-80.
102. Wade S.E., Haegele A.D. Differential measurement of cortisol and cortisone in human saliva by HPLC with Uv detection. J. Liq. Chromatogr. 1991, 14(9):1813-1827.
103. Wan Y., Su Y., Zhu X., Liu G., Fan C. Development of electrochemical immunosensors towards point of care diagnostics. Biosens. Bioelectron. 2013, 47(0):1-11.
104. Wang J. Electrochemical biosensors: towards point-of-care cancer diagnostics. Biosens. Bioelectron. 2006, 21(10):1887-1892.
105. Wang P.M., Cornwell M., Prasunitz M.R. Minimally invasive extraction of dermal interstitial fluid for glucose monitoring using microneedles. Diabetes Technol. Ther. 2005, 7(1):131-141.
106. Xing S., Jiang J., Pan T. Interfacial microfluidic transport on micropatterned superhydrophobic textile. Lab. Chip. 2013, 13(10):1937-1947.
107. Yager P., Domingo G.J., Gerdes J. Point-of-care diagnostics for global health. Annu. Rev. Biomed. Eng. 2008, 10(1):107-144.
108. Yamaguchi M., Matsuda Y., Sasaki S., Sasaki M., Kadoma Y., Imai Y., Niwa D., Shetty V. Immunosensor with fluid control mechanism for salivary cortisol analysis. Biosens. Bioelectron. 2013, 41:186-191.
109. Yamaguchi, M., Yoshikawa, S., Tahara, Y., Niwa, D., Imai, Y., Shetty, V., 2009. Point-of-use measurement of salivary cortisol levels. In: Sensors, 2009 IEEE, pp. 343-346.
110. Yaneva M., Kirilov G., Zacharieva S. Midnight salivary cortisol, measured by highly sensitive electrochemiluminescence immunoassay, for the diagnosis of Cushing's syndrome. Centr. Eur. J. Med. 2009, 4(1):59-64.
111. Yang X.-D., Chang W.-B., Ci Y.-X. Time-resolved fluorescence immunoassay with measurement of a europium chelate in solution: dissociation conditions and application for determination of cortisol. Anal. Chem. 1994, 66(15):2590-2594.
112. Yehuda R., Halligan S.L., Bierer L.M. Cortisol levels in adult offspring of Holocaust survivors: relation to PTSD symptom severity in the parent and child. Psychoneuroendocrinology 2002, 27(1):171-180.
113. Yehuda R., Halligan S.L., Grossman R. Childhood trauma and risk for PTSD: Relationship to intergenerational effects of trauma, parental PTSD, and cortisol excretion. Dev. Psychopathol. 2001, 13(03):733-753.
114. Zhang Y., Kang X., Chen L., Pan C., Yao Y., Gu Z.-Z. Fiber-packed SPE tips based on electrospun fibers. Anal. Bioanal. Chem. 2008, 391(6):2189-2197.