Hair cortisol as a biological marker of chronic stress: Current status, future directions and unanswered questions

Psychoneuroendocrinology

Volumn 37, Issue 5, 2012, Pages 589-601

  Russell, Evan ^a   Koren, Gideon ^a,b,c   Rieder, Michael ^b,d   Van Uum, Stan ^b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b WESTERN UNIVERSITY   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d CHILDREN S HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Chronic stress; Cortisol; Hair analysis

Indexed keywords

GLUCOCORTICOID; HYDROCORTISONE;

ACUTE HEART INFARCTION; ADRENAL INSUFFICIENCY; BIOLOGICAL MONITORING; CHRONIC PAIN; CHRONIC STRESS; CLINICAL ASSESSMENT; CUSHING DISEASE; DEPRESSION; DRUG EXPOSURE; DRUG MEGADOSE; DRUG MONITORING; ENZYME LINKED IMMUNOSORBENT ASSAY; FINGER NAIL; HAIR ANALYSIS; HAIR GROWTH; HAIR LEVEL; HORMONE DETERMINATION; HORMONE SUBSTITUTION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INTERVENTION STUDY; LIQUID CHROMATOGRAPHY; LONG TERM CARE; LONG TERM EXPOSURE; MASS SPECTROMETRY; MATERNAL STRESS; MENTAL STRESS; NONHUMAN; OBSERVATIONAL STUDY; PATHOPHYSIOLOGY; PREMATURE LABOR; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; REVIEW; SALIVA LEVEL; STEROID URINE LEVEL;

ANIMALS; BIOLOGICAL MARKERS; CHRONIC DISEASE; FEMALE; GLUCOCORTICOIDS; HAIR; HUMANS; HYDROCORTISONE; MALE; SALIVA; STRESS, PSYCHOLOGICAL;

EID: 84858450848     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2011.09.009     Document Type: Review

References (78)

1. Aardal E., Holm A.C. Cortisol in saliva-reference ranges and relation to cortisol in serum. Eur. J. Clin. Chem. Clin. Biochem. 1995, 33:927-932.
2. Andenaes R., Kalfoss M.H., Wahl A. Psychological distress and quality of life in hospitalized patients with chronic obstructive pulmonary disease. J. Adv. Nurs. 2004, 46:523-530.
3. Anderson N.B., Nordal K.C., Breckler S.J., Ballard D., Bufka L., Bossolo L., Bethune S., Brownawell A., Kelly K. Stress in America 2011, pp. 1-68, http://www.apa.org/monitor/2011/01/stressed-america.aspx (accessed June 11, 2011).
4. Appels A. Mental precursors of myocardial infarction. Br. J. Psychiatry 1990, 156:465-471.
5. Appels A., Bar F.W., Bar J., Bruggeman C., de Baets M. Inflammation, depressive symptomtology, and coronary artery disease. Psychosom. Med. 2000, 62:601-605.
6. Ashley N.T., Barboza P.S., Macbeth B.J., Janz D.M., Cattet M.R., Booth R.K., Wasser S.K. Glucocorticosteroid concentrations in feces and hair of captive caribou and reindeer following adrenocorticotropic hormone challenge. Gen. Comp. Endocrinol. 2011, 172:382-391.
7. Bechshoft T.O., Sonne C., Dietz R., Born E.W., Novak M.A., Henchey E., Meyer J.S. Cortisol levels in hair of East Greenland polar bears. Sci. Total Environ. 2011, 409:831-834.
8. Bellingrath S., Weigl T., Kudielka B.M. Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance. Biol. Psychol. 2008, 78:104-113.
9. Ben Khelil M., Tegethoff M., Meinlschmidt G., Jamey C., Ludes B., Raul J.S. Simultaneous measurement of endogenous cortisol, cortisone, dehydroepiandrosterone, and dehydroepiandrosterone sulfate in nails by use of UPLC-MS-MS. Anal. Bioanal. Chem. 2011, 401:1153-1162.
10. Bennett A., Hayssen V. Measuring cortisol in hair and saliva from dogs: coat color and pigment differences. Domest. Anim. Endocrinol. 2010, 39:171-180.
11. Boumba V.A., Ziavrou K.S., Vougiouklakis T. Hair as a biological indicator of drug use, drug abuse or chronic exposure to environmental toxicants. Int. J. Toxicol. 2006, 25:143-163.
12. Brady K.T., Sinha R. Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress. Am. J. Psychiatry 2005, 162:1483-1493.
13. Burch W.M. Urine free-cortisol determination. A useful tool in the management of chronic hypoadrenal states. JAMA 1982, 247:2002-2004.
14. Cirimele V., Kintz P., Dumestre V., Goulle J.P., Ludes B. Identification of ten corticosteroids in human hair by liquid chromatography-ionspray mass spectrometry. Forensic Sci. Int. 2000, 107:381-388.
15. Cohen S., Kamarck T., Mermelstein R. A global measure of perceived stress. J. Health Soc. Behav. 1983, 24:385-396.
16. D'Anna-Hernandez K.L., Ross R.G., Natvig C.L., Laudenslager M.L. Hair cortisol levels as a retrospective marker of hypothalamic-pituitary axis activity throughout pregnancy: comparison to salivary cortisol. Physiol. Behav. 2011, 104:348-353.
17. Davenport M.D., Tiefenbacher S., Lutz C.K., Novak M.A., Meyer J.S. Analysis of endogenous cortisol concentrations in the hair of rhesus macaques. Gen. Comp. Endocrinol. 2006, 147:255-261.
18. Dettenborn L., Tietze A., Bruckner F., Kirschbaum C. Higher cortisol content in hair among long-term unemployed individuals compared to controls. Psychoneuroendocrinology 2010, 35:1404-1409.
19. Dettmer A.M., Novak M.A., Suomi S.J., Meyer J.S. Physiological and behavioral adaptation to relocation stress in differentially reared rhesus monkeys: hair cortisol as a biomarker for anxiety-related responses. Psychoneuroendocrinology 2011, 10.1016/j.psyneuen.2011.06.003.
20. Dimsdale J.E. Psychological stress and cardiovascular disease. J. Am. Coll. Cardiol. 2008, 51:1237-1246.
21. Dowlati Y., Herrmann N., Swardfager W., Thomson S., Oh P.I., Van Uum S., Koren G., Lanctot K.L. Relationship between hair cortisol concentrations and depressive symptoms in patients with coronary artery disease. Neuropsychiatr. Dis. Treat. 2010, 6:393-400.
22. Ebbesen S.M., Zachariae R., Mehlsen M.Y., Thomsen D., Hojgaard A., Ottosen L., Petersen T., Ingerslev H.J. Stressful life events are associated with a poor in-vitro fertilization (IVF) outcome: a prospective study. Hum. Reprod. 2009, 24:2173-2182.
23. Esler M., Eikelis N., Schlaich M., Lambert G., Alvarenga M., Dawood T., Kaye D., Barton D., Pier C., Guo L., Brenchley C., Jennings G., Lambert E. Chronic mental stress is a cause of essential hypertension: presence of biological markers of stress. Clin. Exp. Pharmacol. Physiol. 2008, 35:498-502.
24. Fairbanks L.A., Jorgensen M.J., Bailey J.N., Breidenthal S.E., Grzywa R., Laudenslager M.L. Heritability and genetic correlation of hair cortisol in vervet monkeys in low and higher stress environments. Psychoneuroendocrinology 2011, 36:1201-1208.
25. Feng X., Wang L., Yang S., Qin D., Wang J., Li C., Lv L., Ma Y., Hu X. Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:14312-14317.
26. Gaillard Y., Vayssette F., Balland A., Pepin G. Gas chromatographic-tandem mass spectrometric determination of anabolic steroids and their esters in hair. Application in doping control and meat quality control. J. Chromatogr. B: Biomed. Sci. Appl. 1999, 735:189-205.
27. Gao W., Xie Q., Jin J., Qiao T., Wang H., Chen L., Deng H., Lu Z. HPLC-FLU detection of cortisol distribution in human hair. Clin. Biochem. 2010, 43:677-682.
28. Gatti R., Antonelli G., Prearo M., Spinella P., Cappellin E., De Palo E.F. Cortisol assays and diagnostic laboratory procedures in human biological fluids. Clin. Biochem. 2009, 42:1205-1217.
29. Goldstein D.S. Clinical assessment of sympathetic responses to stress. Ann. N.Y. Acad. Sci. 1995, 771:570-593.
30. Gow R., Koren G., Rieder M., Van Uum S. Hair cortisol content in patients with adrenal insufficiency on hydrocortisone replacement therapy. Clin. Endocrinol. (Oxf.) 2011, 74:687-693.
31. Gow R., Thomson S., Rieder M., Van Uum S., Koren G. An assessment of cortisol analysis in hair and its clinical applications. Forensic Sci. Int. 2010, 196:32-37.
32. Hamel A.F., Meyer J.S., Henchey E., Dettmer A.M., Suomi S.J., Novak M.A. Effects of shampoo and water washing on hair cortisol concentrations. Clin. Chim. Acta 2011, 412:382-385.
33. Ito N., Ito T., Kromminga A., Bettermann A., Takigawa M., Kees F., Straub R.H., Paus R. Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J. 2005, 19:1332-1334.
34. Kalra S., Einarson A., Karaskov T., Van Uum S., Koren G. The relationship between stress and hair cortisol in healthy pregnant women. Clin. Invest. Med. 2007, 30:E103-E107.
35. Kessler R.C., Price R.H., Wortman C.B. Social factors in psychopathology: stress, social support, and coping processes. Annu. Rev. Psychol. 1985, 36:531-572.
36. Kim E.Y., Miklowitz D.J., Biuckians A., Mullen K. Life stress and the course of early-onset bipolar disorder. J. Affect. Disord. 2007, 99:37-44.
37. King J.A., Mandansky D., King S., Fletcher K.E., Brewer J. Early sexual abuse and low cortisol. Psychiatry Clin. Neurosci. 2001, 55:71-74.
38. Kirschbaum C., Tietze A., Skoluda N., Dettenborn L. Hair as a retrospective calendar of cortisol production-increased cortisol incorporation into hair in the third trimester of pregnancy. Psychoneuroendocrinology 2009, 34:32-37.
39. Koren L., Mokady O., Geffen E. Social status and cortisol levels in singing rock hyraxes. Horm. Behav. 2008, 54:212-216.
40. Koren L., Mokady O., Karaskov T., Klein J., Koren G., Geffen E. A novel method using hair for determining hormonal levels in wildlife. Anim. Behav. 2002, 63:403-406.
41. Kramer M.S., Lydon J., Seguin L., Goulet L., Kahn S.R., McNamara H., Genest J., Dassa C., Chen M.F., Sharma S., Meaney M.J., Thomson S., Van Uum S., Koren G., Dahhou M., Lamoureux J., Platt R.W. Stress pathways to spontaneous preterm birth: the role of stressors, psychological distress, and stress hormones. Am. J. Epidemiol. 2009, 169:1319-1326.
42. Latendresse G. The interaction between chronic stress and pregnancy: preterm birth from a biobehavioral perspective. J. Midwifery Womens Health 2009, 54:8-17.
43. Laudenslager M.L., Jorgensen M.J., Grzywa R., Fairbanks L.A. A novelty seeking phenotype is related to chronic hypothalamic-pituitary-adrenal activity reflected by hair cortisol. Physiol. Behav. 2011, 104:291-295.
44. Lee S., Jeong J., Kwak Y., Park S.K. Depression research: where are we now?. Mol. Brain 2010, 3:8.
45. Loussouarn G., El R.C., Genain G. Diversity of hair growth profiles. Int. J. Dermatol. 2005, 44(Suppl 1):6-9.
46. Macbeth B.J., Cattet M.R.L., Stenhouse G.B., Gibeau M.L., Janz D.M. Hair cortisol concentration as a noninvasive measure of long-term stress in free-ranging grizzly bears (Ursus arctos): considerations with implications for other wildlife. Can. J. Zool. 2010, 88:935-949.
47. Malhotra S.K., Mehta V. Role of stressful life events in induction or exacerbation of psoriasis and chronic urticaria. Indian J. Dermatol. Venereol. Leprol. 2008, 74:594-599.
48. Manenschijn L., Jetten A.M., van Wamel W.J., Tavakol M., Koper J.W., van den Akker E.L., van B.A., van Rossum E.F. Long-term cortisol levels are not associated with nasal carriage of Staphylococcus aureus. Eur. J. Clin. Microbiol. Infect. Dis. 2011, 10.1007/s10096-011-1282-2.
49. Manenschijn L., Koper J.W., Lamberts S.W., van Rossum E.F. Evaluation of a method to measure long term cortisol levels. Steroids 2011, 76:1032-1036.
50. Mason J.W., Giller E.L., Kosten T.R., Ostroff R.B., Podd L. Urinary free-cortisol levels in posttraumatic stress disorder patients. J. Nerv. Ment. Dis. 1986, 174:145-149.
51. Mawdsley J.E., Macey M.G., Feakins R.M., Langmead L., Rampton D.S. The effect of acute psychologic stress on systemic and rectal mucosal measures of inflammation in ulcerative colitis. Gastroenterology 2006, 131:410-419.
52. McEwen B.S. Stress, adaptation, and disease. Allostasis and allostatic load. Ann. N.Y. Acad. Sci. 1998, 840:33-44.
53. Miller G.E., Chen E., Zhou E.S. If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol. Bull. 2007, 133:25-45.
54. Pereg D., Gow R., Mosseri M., Lishner M., Rieder M., Van Uum S., Koren G. Hair cortisol and the risk for acute myocardial infarction in adult men. Stress 2011, 14:73-81.
55. Pouwer F., Kupper N., Adriaanse M.C. Does emotional stress cause type 2 diabetes mellitus? A review from the European Depression in Diabetes (EDID) Research Consortium. Discov. Med. 2010, 9:112-118.
56. Pragst F., Balikova M.A. State of the art in hair analysis for detection of drug and alcohol abuse. Clin. Chim. Acta 2006, 370:17-49.
57. Puchala R., Prieto I., Banskalieva V., Goetsch A.L., Lachica M., Sahlu T. Effects of bovine somatotropin and thyroid hormone status on hormone levels, body weight gain, and mohair fiber growth of Angora goats. J. Anim. Sci. 2001, 79:2913-2919.
58. Raul J.S., Cirimele V., Ludes B., Kintz P. Detection of physiological concentrations of cortisol and cortisone in human hair. Clin. Biochem. 2004, 37:1105-1111.
59. Sandberg S., Jarvenpaa S., Penttinen A., Paton J.Y., McCann D.C. Asthma exacerbations in children immediately following stressful life events: a Cox's hierarchical regression. Thorax 2004, 59:1046-1051.
60. Sauve B., Koren G., Walsh G., Tokmakejian S., Van Uum S.H. Measurement of cortisol in human hair as a biomarker of systemic exposure. Clin. Invest. Med. 2007, 30:E183-E191.
61. Selye H. Stress and the general adaptation syndrome. Br. Med. J. 1950, 1:1383-1392.
62. Sharpley C.F., Kauter K.G., McFarlane J.R. An initial exploration of in vivo hair cortisol responses to a brief pain stressor: latency, localization and independence effects. Physiol. Res. 2009, 58:757-761.
63. Stalder T., Kirschbaum C., Heinze K., Steudte S., Foley P., Tietze A., Dettenborn L. Use of hair cortisol analysis to detect hypercortisolism during active drinking phases in alcohol-dependent individuals. Biol. Psychol. 2010, 85:357-360.
64. Steudte S., Kolassa I.T., Stalder T., Pfeiffer A., Kirschbaum C., Elbert T. Increased cortisol concentrations in hair of severely traumatized Ugandan individuals with PTSD. Psychoneuroendocrinology 2011, 36:1193-1200.
65. Steudte S., Stalder T., Dettenborn L., Klumbies E., Foley P., Beesdo-Baum K., Kirschbaum C. Decreased hair cortisol concentrations in generalised anxiety disorder. Psychiatry Res. 2011, 186:310-314.
66. Thomson S., Koren G., Fraser L.A., Rieder M., Friedman T.C., Van Uum S.H. Hair analysis provides a historical record of cortisol levels in Cushing's syndrome. Exp. Clin. Endocrinol. Diabetes 2010, 118:133-138.
67. Tiganescu A., Walker E.A., Hardy R.S., Mayes A.E., Stewart P.M. Localization, age- and site-dependent expression, and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in skin. J. Invest. Dermatol. 2011, 131:30-36.
68. Van Rossum E.F.C., Manenschijn L., Spijker A.T., Koper J.W., Jetten A.M., Giltay E.J., Haffmans J., Hoencamp E. Long-term cortisol measured in scalp hair in patients with bipolar disorder: associations with age of onset and psychiatric comorbidity. International Society of Psychoneuroendocrinology 2011, 64-65. http://www.ispne.org/conference/agenda-final.pdf.
69. Van Uum S.H., Sauve B., Fraser L.A., Morley-Forster P., Paul T.L., Koren G. Elevated content of cortisol in hair of patients with severe chronic pain: a novel biomarker for stress. Stress 2008, 11:483-488.
70. Vicennati V., Pasqui F., Cavazza C., Pagotto U., Pasquali R. Stress-related development of obesity and cortisol in women. Obesity 2009, 17:1678-1683.
71. Vining R.F., McGinley R.A., Maksvytis J.J., Ho K.Y. Salivary cortisol: a better measure of adrenal cortical function than serum cortisol. Ann. Clin. Biochem. 1983, 20(Pt 6):329-335.
72. Vogelzangs N., Beekman A.T., Milaneschi Y., Bandinelli S., Ferrucci L., Penninx B.W. Urinary cortisol and six-year risk of all-cause and cardiovascular mortality. J. Clin. Endocrinol. Metab. 2010, 95:4959-4964.
73. Warnock F., McElwee K., Seo R.J., McIsaac S., Seim D., Ramirez-Aponte T., Macritchie K.A., Young A.H. Measuring cortisol and DHEA in fingernails: a pilot study. Neuropsychiatr. Dis. Treat. 2010, 6:1-7.
74. Webb E., Thomson S., Nelson A., White C., Koren G., Rieder M., Van Uum S. Assessing individual systemic stress through cortisol analysis of archaeological hair. J. Archeol. Sci. 2011, 37:807-812.
75. Wennig R. Potential problems with the interpretation of hair analysis results. Forensic Sci. Int. 2000, 107:5-12.
76. Yamada J., Stevens B., de S.N., Gibbins S., Beyene J., Taddio A., Newman C., Koren G. Hair cortisol as a potential biologic marker of chronic stress in hospitalized neonates. Neonatology 2007, 92:42-49.
77. Yehuda R., Halligan S.L., Golier J.A., Grossman R., Bierer L.M. Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder. Psychoneuroendocrinology 2004, 29:389-404.
78. Yehuda R., Levengood R.A., Schmeidler J., Wilson S., Guo L.S., Gerber D. Increased pituitary activation following metyrapone administration in post-traumatic stress disorder. Psychoneuroendocrinology 1996, 21:1-16.