Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway

Acta Pharmacologica Sinica

Volumn 34, Issue 11, 2013, Pages 1386-1396

  Zhang, Mei Qi ^a   Zheng, Yue Liang ^a   Chen, Huan ^a   Tu, Jian Feng ^a   Shen, Ye ^a   Guo, Jun Ping ^a   Yang, Xiang Hong ^a   Yuan, Shu Ren ^b   Chen, Liang Zhong ^b   Chai, Jing Jie ^b   Lu, Jian Hong ^b   Zhai, Chang Lin ^b  

^a ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b HANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

Author keywords

Akt; Apoptosis; Bim; FOXO3a; Heart attack; LY294002; Myocardial ischemia reperfusion; PI3K; Sodium tanshinone IIA sulfonate

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BIM PROTEIN; CASPASE 3; HYDROGEN PEROXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TANSHINONE IIA; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EX VIVO STUDY; FLOW CYTOMETRY; HEART FUNCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE DP-DT; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEART PROTECTION; IMMUNOBLOTTING; MALE; NEWBORN; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; RISK ASSESSMENT; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARDIOTONIC AGENTS; CHROMONES; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; IN SITU NICK-END LABELING; MALE; MEMBRANE PROTEINS; MORPHOLINES; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PHENANTHRENES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84887336835     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.91     Document Type: Article

References (37)

1. Choi H, Kim SH, Chun YS, Cho YS, Park JW, Kim MS. In vivo hyperoxic preconditioning prevents myocardial infarction by expressing bcl-2. Exp Biol Med 2006; 231: 463-72.
2. Tian Y, Zhang W, Xia D, Modi P, Liang D, Wei M. Postconditioning inhibits myocardal apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway. J Biomed Sci 2011; 18: 53.
3. Zhai CL, Zhang MQ, Zhang Y, Xu HX, Wang JM, An GP, et al. Glycyrrhizin protects rat heart against ischemia-reperfusion injury through the blockade of HMGB1-dependent phospho-JNK/Bax pathway. Acta Pharmacol Sin 2012; 33: 1477-87.
4. Freude B, Masters TN, Robicsek F, Fokin A, Kostin S, Zimmermann R, et al. Apoptosis is initiated by myocardial ischemia and executed during reperfusion. J Mol Cell Cardiol 2000; 32: 197-208. (Pubitemid 30670343)
5. Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the reperfusion injury salvage kinase (RISK)-pathway. Cardiovasc Res 2004; 61: 448-60. (Pubitemid 38210151)
6. Skurk C, Izumiya Y, Maatz H, Razeqhi P, Shiojima I, Sandri M, et al. The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J Biol Chem 2005; 280: 20814-23. (Pubitemid 40776786)
7. Yang JY, Xia W, Hu MC. Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. Int J Oncol 2006; 29: 643-8.
8. Yang JY, Hung MC. Deciphering the role of the forkhead transcription factors in cancer therapy. Curr Drug Targets 2011; 12: 1284-90.
9. Weston CR, Balmanno K, Chalmers C, Hadfield K, Molton SA, Lev R, et al. Activation of ERK1/2 deltaRaf-1: ER represses Bim expression independently of the JNK or PI3K pathways. Oncogene 2003; 22: 1281-93. (Pubitemid 36388747)
10. Zhou GY, Zhao BL, Hou JW, Ma GE, Xin WJ. Protective effects of sodium tanshione IIA sulphonate against adriamycin-induced lipid peroxidation in mice hearts in vivo and in vitro. Pharmacol Res 1999; 40: 487-91.
11. Shang Q, Xu H, Huang L. Tanshinone IIA: a promising natural cardio-protective agent. Evid Based Complement Alternat Med 2012. Doi: 10.1155/2012/716459.
12. Cheng TO. Cardiovascular effects of Danshen. Int J Cardiol 2007; 121: 9-22. (Pubitemid 47287779)
13. Jiang B, Zhang L, Wang Y, Li M, Wu W, Guan S, et al. Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo. Food Chem Toxicol 2009; 47: 1538-44.
14. Yang R, Liu A, Ma X, Li L, Su D, Liu J. Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation. J Cardiovasc Pharmacol 2008; 51: 396-401. (Pubitemid 351572239)
15. Juhasz B, Thirunavukkarasu M, Pant R, Zhan L, Penumathsa SV, Secor ER Jr, et al. Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium. Am J Physiol Heart Circ Physiol 2008; 294: H1365-70. (Pubitemid 351468735)
16. Penumathsa SV, Koneru S, Thirunavukkarasu M, Zhan L, Prasad K, Maulik N. Secoisolariciresinol diglucoside: relevance to angiogenesis and cardioprotection against ishcemia-reperfusion injury. J Pharmacol Exp Ther 2007; 320: 951-9. (Pubitemid 46147980)
17. Penumathsa SV, Thirunavukkarasu M, Koneru S, Juhasz B, Zhan L, Pant R, et al. Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat. J Mol Cell Cardiol 2007; 42: 508-16. (Pubitemid 46349117)
18. Hu X, Zhou X, He B, Xu C, Wu L, Cui B, et al. Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Eur J Pharmacol 2010; 638: 84-9.
19. Sgobbo P, Pacelli C, Grattagliano I, Villani G, Cocco T. Carvedilol inhibits mitochondrial complex I and induces resistance to H2O2-mediated oxidative insult in H9C2 myocardial cells. Biochim Biophys Acta 2007; 1767: 222-32. (Pubitemid 46400605)
20. Kim CH, Hao J, Ahn HY, Kim SW. Activation of Akt/protein kinase B mediates the protective effects of mechanical streching against myocardial ischemia-reperfusion injury. J Vet Sci 2012; 13: 235-44.
21. Hong HJ, Liu JC, Chen JJ, Chan P, Cheng TH. Tanshinone IIA prevents doxorubicin-induced cardiomyocyte apoptosis through Akt-dependent pathway. Int J Cardiol 2012; 157: 174-9.
22. Zhang Y, Wei L, Sun D, Cao F, Gao H, Zhao L, et al. Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats. Diabetes Obes Metab 2010; 12: 316-22.
23. Li XH, Tang RY. Relationship between inhibitory action of tanshinone on neutrophil function and its prophylactic effects on myocardial infarction. Zhongguo Yao Li Xue Bao 1999 ; 12: 269-72.
24. Shanghai Cooperative Group for the Study of Tanshinone IIA. Thera-peutic effect of sodium tanshinone IIA sulfonate in patients with coronary heart diseases: a double blind study. J Tradit Clin Med 1984; 4: 20-4.
25. Fan HY, Yang L, Fu FH, Xu H, Meng QG, Zhu HB, et al. Cardioprotective effects of salvianolic acid a on myocardial ischemia-reperfusion injury in vivo and in vitro. Evidence-based complementary and alternative medicine. 2011; doi: 10.1155/2012/508938.
26. Zhou G, Jiang W, Zhao Y, Ma G, Xin W, Yin J, et al. Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria. Biochem Pharmacol 2003; 65: 51-7. (Pubitemid 35447838)
27. Xu CQ, Cang JS, He XM. Inhibition effect of tanshinone IIA on electron current of L-calcium in rat heart cell. Acta Pharmacol Toxicol Sin 1996; 12: 85-8.
28. +-ATPase in rat heart and brain. Acta Pharmacol Toxicol Sin 1994; 8: 19-23.
29. Zuo YJ, Li YQ, Wang G. Effect of tanshinone IIA sulfonic acid natrium injection on angina pectoris and hemorrheology in patients with coronary artery disease. Prog Mod Biomed 2007; 7: 732-4.
30. Zhao H, Sapolsky RM, Steinberg GK. Phosphoinositide-3-kinase/Akt survival pathways are implicated in neuronal survival after stroke. Mol Neurobiol 2006; 34: 249-70.
31. Alloatti G, Arnoletti E, Bassino E, Penna C, Perrelli MG, Ghe C, et al. Obestatin affords cardioprotection to the ischemic-reperfused isolated rat heart and inhibits apoptosis in cultures of similary stressed cardiomyocytes. Am J Physiol Heart Circ Physiol 2010; 299: H470-81.
32. Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004; 117: 421-6. (Pubitemid 38610228)
33. Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, et al. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem 2004; 279: 1513-25. (Pubitemid 38082681)
34. Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005; 24: 7410-25. (Pubitemid 41637981)
35. Brunet A, Bonni A, Ziqmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcriptin factor. Cell 1999; 96: 857-68. (Pubitemid 29165088)
36. Gilley J, Coffer PJ, Ham J. FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 2003; 162: 613-22. (Pubitemid 37022939)
37. Urbich C, Knau A, Fichtlscherer S, Walter DH, Bruhl T, Potente M, et al. FOXO-dependent expression of the proapoptotic protein Bim: Pivotal role for apoptosis signaling in endothelial progenitor cells. FASEB J 2005; 19: 974-6. (Pubitemid 40827722)