Tanshinone IIA prevents doxorubicin-induced cardiomyocyte apoptosis through Akt-dependent pathway

International Journal of Cardiology

Volumn 157, Issue 2, 2012, Pages 174-179

  Hong, Hong Jye ^a   Liu, Ju Chi ^b   Chen, Po Yuan ^a   Chen, Jin Jer ^c,d,e   Chan, Paul ^b   Cheng, Tzu Hurng ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Akt; Cardiomyocyte apoptosis; Doxorubicin; Tanshinone IIA; Traditional Chinese medicine

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CYTOCHROME C; DOXORUBICIN; PROTEIN BCL XL; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TANSHINONE IIA; WORTMANNIN;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL PROTECTION; CELLULAR DISTRIBUTION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; QUANTITATIVE STUDY; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CARDIOTONIC AGENTS; CELLS, CULTURED; DITERPENES, ABIETANE; DOXORUBICIN; DRUGS, CHINESE HERBAL; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION;

EID: 84861093906     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2010.12.012     Document Type: Article

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