How does the cell overcome LCP nanoparticle-induced calcium toxicity?

Molecular Pharmaceutics

Volumn 10, Issue 11, 2013, Pages 4391-4395

  Tseng, Yu Cheng ^a   Yang, Angela ^a   Huang, Leaf ^a  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

Author keywords

calcium indicator; intracellular calcium; LCP; nanoparticle toxicity

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; LIPID CALCIUM PHOSPHATE NANOPARTICLE; NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE; CELLS; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCIUM; CELL LINE, TUMOR; HUMANS; MICE; MICE, NUDE; NANOPARTICLES;

EID: 84887333383     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400028m     Document Type: Article

References (22)

1. Zhang, Y.; Kim, W. Y.; Huang, L. Systemic Delivery of Gemcitabine Triphosphate Via LCP Nanoparticles for NSCLC and Pancreatic Cancer Therapy Biomaterials 2013, 34, 3447-3458
2. Zhang, Y.; Schwerbrock, N. M.; Rogers, A. B.; Kim, W. Y.; Huang, L. Codelivery of VEGF SiRNA and Gemcitabine Monophosphate in a Single Nanoparticle Formulation for Effective Treatment of NSCLC Mol. Ther. 2013, 21, 1559-1569
3. Li, J.; Yang, Y.; Huang, L. Calcium Phosphate Nanoparticles with an Asymmetric Lipid Bilayer Coating for Sirna Delivery to the Tumor J. Controlled Release 2012, 158, 108-14
4. Yang, Y.; Hu, Y.; Wang, Y.; Li, J.; Liu, F.; Huang, L. Nanoparticle Delivery of Pooled siRNA for Effective Treatment of Non-Small Cell Lung Caner Mol. Pharmaceutics 2012, 9 (8) 2280-9
5. Yang, Y.; Li, J.; Liu, F.; Huang, L. Systemic Delivery of Sirna Via Lcp Nanoparticle Efficiently Inhibits Lung Metastasis Mol. Ther. 2012, 20, 609-15
6. Li, J.; Chen, Y. C.; Tseng, Y. C.; Mozumdar, S.; Huang, L. Biodegradable Calcium Phosphate Nanoparticle with Lipid Coating for Systemic siRNA Delivery J. Controlled Release 2010, 142, 416-21
7. Kingston, R. E.; Chen, C. A.; Rose, J. K. Calcium Phosphate Transfection Curr. Protoc. Mol. Biol. 2003, 9.1.1-9.1.11
8. Clapham, D. E. Calcium Signaling Cell 2007, 131, 1047-58
9. Burgoyne, R. D. Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling Nat. Rev. Neurosci. 2007, 8, 182-93
10. Petersen, O. H. Ca2+ Signalling and Ca2+-Activated Ion Channels in Exocrine Acinar Cells Cell Calcium 2005, 38, 171-200
11. Rizzuto, R.; Pozzan, T. Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences Physiol. Rev. 2006, 86, 369-408
12. Zong, W. X.; Thompson, C. B. Necrotic Death as a Cell Fate Genes Dev. 2006, 20, 1-15
13. Vanlangenakker, N.; Vanden Berghe, T.; Krysko, D. V.; Festjens, N.; Vandenabeele, P. Molecular Mechanisms and Pathophysiology of Necrotic Cell Death Curr. Mol. Med. 2008, 8, 207-20
14. Wrogemann, K.; Pena, S. D. Mitochondrial Calcium Overload: A General Mechanism for Cell-Necrosis in Muscle Diseases Lancet 1976, 1, 672-4
15. Landon, E. J.; Naukam, R. J.; Rama Sastry, B. V. Effects of Calcium Channel Blocking Agents on Calcium and Centrilobular Necrosis in the Liver of Rats Treated with Hepatotoxic Agents Biochem. Pharmacol. 1986, 35, 697-705
16. McConkey, D. J.; Orrenius, S. The Role of Calcium in the Regulation of Apoptosis J. Leukocyte Biol. 1996, 59, 775-83
17. Nicholls, D. G. Intracellular Calcium Homeostasis Br. Med. Bull. 1986, 42, 353-8
18. Chaudhary, J.; Walia, M.; Matharu, J.; Escher, E.; Grover, A. K. Caloxin: A Novel Plasma Membrane Ca2+ Pump Inhibitor Am. J. Physiol. 2001, 280, C1027-30
19. Szewczyk, M. M.; Pande, J.; Grover, A. K. Caloxins: A Novel Class of Selective Plasma Membrane Ca2+ Pump Inhibitors Obtained Using Biotechnology Pfluegers Arch. 2008, 456, 255-66
20. Holmes, M. E.; Chaudhary, J.; Grover, A. K. Mechanism of Action of the Novel Plasma Membrane Ca(2+)-Pump Inhibitor Caloxin Cell Calcium 2003, 33, 241-5
21. Garcia-Rivas Gde, J.; Carvajal, K.; Correa, F.; Zazueta, C. Ru360, a Specific Mitochondrial Calcium Uptake Inhibitor, Improves Cardiac Post-Ischaemic Functional Recovery in Rats in Vivo Br. J. Pharmacol. 2006, 149, 829-37
22. Griffiths, E. J. Mitochondrial Calcium Transport in the Heart: Physiological and Pathological Roles J. Mol. Cell. Cardiol. 2009, 46, 789-803