Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 45, 2013, Pages 18064-18069

  Eichhorn, Tim R ^a,b   Takado, Yuhei ^a   Salameh, Najat ^a   Capozzi, Andrea ^a   Cheng, Tian ^a   Hyacinthe, Jean Noël ^c   Mishkovsky, Mor ^a,d   Roussel, Christophe ^a   Comment, Arnaud ^a  

^a EPFL   (Switzerland)

^b PAUL SCHERRER INSTITUTE   (Switzerland)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Acetate; Lactate; Metabolism; Nuclear magnetic resonance; Pyruvate

Indexed keywords

CARBON 13; PYRUVIC ACID; RADICAL;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DISSOLUTION; HYPERPOLARIZATION; IMAGING; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POLARIZATION; PRIORITY JOURNAL; RAT; REAL TIME METABOLIC IMAGING; ULTRAVIOLET RADIATION;

ACETATE; LACTATE; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PYRUVATE;

ANIMALS; CARBON ISOTOPES; ELECTRON SPIN RESONANCE SPECTROSCOPY; FOURIER ANALYSIS; FREE RADICALS; MAGNETIC RESONANCE IMAGING; METABOLISM; MICE; MOLECULAR IMAGING; PYRUVIC ACID; ULTRAVIOLET RAYS;

EID: 84887303338     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1314928110     Document Type: Article

References (36)

1. Shulman RG, Rothman DL (2001) 13C NMR of intermediary metabolism: Implications for systemic physiology. Annu Rev Physiol 63:15-48.
2. Abragam A, Goldman M (1978) Principles of dynamic nuclear-polarization. Rep Prog Phys 41(3):395-467.
3. Ardenkjaer-Larsen JH, et al. (2003) Increase in signal-to-noise ratio of > 10, 000 times in liquid-state NMR. Proc Natl Acad Sci USA 100(18):10158-10163.
4. Gallagher FA, Kettunen MI, Brindle KM (2009) Biomedical applications of hyperpolarized C-13 magnetic resonance imaging. Prog Nucl Magn Reson Spectrosc 55(4): 285-295.
5. Gallagher FA, et al. (2009) Production of hyperpolarized [1, 4-13C2]malate from [1, 4- 13C2]fumarate is a marker of cell necrosis and treatment response in tumors. Proc Natl Acad Sci USA 106(47):19801-19806.
6. Golman Kint Zandt R, Thaning M (2006) Real-time metabolic imaging. Proc Natl Acad Sci USA 103(30):11270-11275.
7. Mishkovsky M, Comment A, Gruetter R (2012) In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance. J Cereb Blood Flow Metab 32(12):2108-2113.
8. Schroeder MA, et al. (2009) Real time, in vivo observation of oxidative carbohydrate metabolism reveals the key regulatory role of acetyl-carnitine as a substrate buffer in the heart. Circulation 120(18):S855-S856.
9. Albers MJ, et al. (2008) Hyperpolarized 13C lactate, pyruvate, and alanine: Noninvasive biomarkers for prostate cancer detection and grading. Cancer Res 68(20): 8607-8615.
10. Day SE, et al. (2007) Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat Med 13(11): 1382-1387.
11. Hurd RE, et al. (2010) Cerebral dynamics and metabolism of hyperpolarized [1-(13)C] pyruvate using time-resolved MR spectroscopic imaging. J Cereb Blood Flow Metab 30(10):1734-1741.
12. Lau AZ, et al. (2013) Noninvasive identification and assessment of functional brown adipose tissue in rodents using hyperpolarized (13)C imaging. Int J Obes (Lond), 10.1038/ijo.2013.58.
13. Marjanska M, et al. (2010) In vivo 13C spectroscopy in the rat brain using hyperpolarized [1-(13)C]pyruvate and [2-(13)C]pyruvate. J Magn Reson 206(2):210-218.
14. Park I, et al. (2010) Hyperpolarized 13C magnetic resonance metabolic imaging: Application to brain tumors. Neuro Oncol 12(2):133-144.
15. Park JM, et al. (2013) Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging. Neuro Oncol 15(4):433-441.
16. Schroeder MA, et al. (2013) Hyperpolarized (13)C magnetic resonance reveals earlyand late-onset changes to in vivo pyruvate metabolism in the failing heart. Eur J Heart Fail 15(2):130-140.
17. Kurhanewicz J, et al. (2011) Analysis of cancer metabolism by imaging hyperpolarized nuclei: Prospects for translation to clinical research. Neoplasia 13(2):81-97.
18. Nelson SJ, et al. (2013) Metabolic imaging of patients with prostate cancer using hyperpolarized [1-13c]pyruvate. Sci Transl Med 5(198):198-108.
19. Budac D, Wan P (1992) Photodecarboxylation - mechanism and synthetic utility. J Photochem Photobiol A 67(2):135-166.
20. Leermakers PA, Vesley GF (1963) Photolysis of pyruvic acid in solution. J Org Chem 28(4):1160-1161.
21. Lieben F, Lowe L, Bauminger B (1934) The decomposition of high polymer carbohydrate as well as lactic acid and pyruvic acid in the light of quartz lamps. Biochem Z 271:209-212.
22. Skutches CL, Holroyde CP, Myers RN, Paul P, Reichard GA (1979) Plasma acetate turnover and oxidation. J Clin Invest 64(3):708-713.
23. Comment A, et al. (2007) Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner. Concepts Magn Reson 31B(4):255-269.
24. Jóhannesson H, Macholl S, Ardenkjaer-Larsen JH (2009) Dynamic nuclear polarization of [1-13C]pyruvic acid at 4.6 tesla. J Magn Reson 197(2):167-175.
25. Jannin S, et al. (2008) A 140 GHz prepolarizer for dissolution dynamic nuclear polarization. J Chem Phys 128(24):241102.
26. Malloy CR, Merritt ME, Sherry AD (2011) Could 13C MRI assist clinical decision-making for patients with heart disease? NMR Biomed 24(8):973-979.
27. Ardenkjaer-Larsen JH, et al. (2011) Dynamic nuclear polarization polarizer for sterile use intent. NMR Biomed 24(8):927-932.
28. Frei K, Bernstein HJ (1963) Carbon-carbon spin-coupling constants in characteristic CC-bond types. J Chem Phys 38(5):1216-1226.
29. Karabatsos G (1961) Spin-spin coupling constants between non-bonded C13 and protons in some C13-labeled compounds. J Am Chem Soc 83(5):1230-1232.
30. Mishkovsky M, Cheng T, Comment A, Gruetter R (2012) Localized in vivo hyperpolarization transfer sequences. Magn Reson Med 68(2):349-352.
31. Fulmer GR, et al. (2010) NMR chemical shifts of trace impurities: Common laboratory solvents, organics, and gases in deuterated solvents relevant to the organometallic chemist. Organometallics 29(9):2176-2179.
32. Comment A, van der Klink J (2011) US Patent 8, 034, 027.
33. Cheng T, et al. (2013) Automated transfer and injection of hyperpolarized molecules with polarization measurement prior to in vivo NMR. NMR Biomed, 10.1002/nbm.2993.
34. Gruetter R, Tkác I (2000) Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 43(2):319-323.
35. Staewen RS, et al. (1990) 3-D FLASH imaging using a single surface coil and a new adiabatic pulse, BIR-4. Invest Radiol 25(5):559-567.
36. Scheffler K, Lehnhardt S (2003) Principles and applications of balanced SSFP techniques. Eur Radiol 13(11):2409-2418.