Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity

PLoS Pathogens

Volumn 9, Issue 10, 2013, Pages

  Worthington, John J ^a,b   Klementowicz, Joanna E ^a,b   Rahman, Sayema ^a   Czajkowska, Beata I ^a,b   Smedley, Catherine ^a,b   Waldmann, Herman ^c   Sparwasser, Tim ^d   Grencis, Richard K ^a,b   Travis, Mark A ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHAVBETA8 INTEGRIN; CD11 ANTIGEN; DIPHTHERIA TOXIN; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; INTEGRIN; INTERLEUKIN 13; INTERLEUKIN 4; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ABLATION THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HELMINTHIASIS; IMMUNE RESPONSE; MOUSE; NONHUMAN; PARASITE IMMUNITY; PARASITOSIS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T CELL DEPLETION; TH1 TH2 BALANCE; TRICHURIS MURIS; WESTERN BLOTTING;

ANIMALS; CHRONIC DISEASE; DENDRITIC CELLS; INTEGRINS; INTERLEUKIN-13; INTESTINAL DISEASES, PARASITIC; MICE; MICE, KNOCKOUT; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA; TRICHURIASIS; TRICHURIS;

EID: 84887291454     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003675     Document Type: Article

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