Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 723-739

  Pisani, Leonardo ^a   Catto, Marco ^a   Nicolotti, Orazio ^a   Grossi, Giancarlo ^b   Di Braccio, Mario ^b   Soto Otero, Ramon ^c   Mendez Alvarez, Estefania ^c   Stefanachi, Angela ^a   Gadaleta, Domenico ^a   Carotti, Angelo ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

4 Substituted 7 benzyloxy 2H chromene 2 ones; Alzheimer's disease; Molecular docking; Monoamine oxidase inhibitors; Neurodegenerative diseases; Parkinson's disease; Selective MAO B inhibitors

Indexed keywords

4 AMINO 7 [(3 CHLOROBENZYL)OXY] 2H CHROMEN 2 ONE; 4 ANILINO 7 [(3 CHLOROBENZYL)OXY] 2H CHROMEN 2 ONE; 4 CHLORO 7 [(3 CHLOROBENZYL)OXY] 2H CHROMEN 2 ONE; 4 [(BUTYLAMINO)METHYL] 7 [(3 CHLOROBENZYL)OXY] 2H CHROMEN 2 ONE; 7 [(3 BROMOBENZYL)OXY] 4 HYDROXY 2H CHROMEN 2 ONE; 7 [(3 CHLOROBENZYL)OXY] 4 (CHLOROMETHYL) 2H CHROMEN 2 ONE; 7 [(3 CHLOROBENZYL)OXY] 4 (ETHYLAMINO) 2H CHROMEN 2 ONE; 7 [(3 CHLOROBENZYL)OXY] 4 (HYDROXYMETHYL) 2H CHROMEN 2 ONE; 7 [(3 CHLOROBENZYL)OXY] 4 (ISOPROPYLAMINO) 2H CHROMEN 2 ONE; 7 [(3 CHLOROBENZYL)OXY] 4 (METHYLAMINO) 2H CHROMEN 2 ONE; 7 [(3 CHLOROBENZYL)OXY] 4 ETHYL 2H CHROMEN 2 ONE; 7 [(3 CHLOROBENZYL)OXY] 4 HYDROXY 2H CHROMEN 2 ONE; 7 [(3 CHLOROBENZYL)OXY] 4 PHENOXY 2H CHROMEN 2 ONE; 7 [(3 CHLOROBENZYL)OXY] 4 [(PROPYLAMINO)METHYL] 2H CHROMEN 2 ONE; 7 [(3 FLUOROBENZYL)OXY] 4 HYDROXY 2H CHROMEN 2 ONE; BROFAROMINE; CHROMENE DERIVATIVE; CLORGYLINE; COUMARIN DERIVATIVE; ETHYL [7 [(3 CHLOROBENZYL)OXY] 2 OXO 2H CHROMEN 4 YL] CARBAMATE; MOCLOBEMIDE; MONOAMINE OXIDASE B INHIBITOR; N [7 [(3 CHLOROBENZYL)OXY] 2 OXO 2H CHROMEN 4 YL] ACETAMIDE; N [7 [(3 CHLOROBENZYL)OXY] 2 OXO 2H CHROMEN 4 Y] N' ETHYLUREA; PHENELZINE; RASAGILINE; SELEGILINE; TOLOXATONE; TRANYLCYPROMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; ARTICLE; DEGENERATIVE DISEASE; DISEASES; DRUG ANALYSIS; DRUG POTENCY; IC 50; KNOWLEDGE; LIPOPHILICITY; METABOLITE; MOLECULAR DOCKING; PHYSICAL CHEMISTRY; SIMULATION; STRUCTURE ACTIVITY RELATION;

4-SUBSTITUTED-7-BENZYLOXY-2H-CHROMENE-2-ONES; ALZHEIMER'S DISEASE; MOLECULAR DOCKING; MONOAMINE OXIDASE INHIBITORS; NEURODEGENERATIVE DISEASES; PARKINSON'S DISEASE; SELECTIVE MAO-B INHIBITORS;

CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84887272848     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.034     Document Type: Article

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