Synthesis and in vitro inhibitory activity on human platelet aggregation of novel properly substituted 4-(1-piperazinyl)coumarins

European Journal of Medicinal Chemistry

Volumn 39, Issue 5, 2004, Pages 397-409

  Di Braccio, Mario ^a   Grossi, Giancarlo ^a   Roma, Giorgio ^a   Signorello, Maria Grazia ^a   Leoncini, Giuliana ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Antiplatelet activity; Structure activity relationships; Substituted 4 (1 piperazinyl)coumarins; Synthesis

Indexed keywords

7 BUTOXY 8 METHYL 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 7 ISOPROPOXY 8 METHYL 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 4 (1 PIPERAZINYL) 7 (3 PYRIDYLMETHOXY)COUMARIN; 8 METHYL 4 (1 PIPERAZINYL) 7 (4 PYRIDYLMETHOXY) 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 4 (1 PIPERAZINYL) 7 PROPOXY 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 7 (1 NAPHTHYLMETHOXY) 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 7 (1 PHENYLETHOXY) 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; CALCIMYCIN; COLLAGEN; COUMARIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; EVALUATION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RICH PLASMA;

ADENOSINE DIPHOSPHATE; BLOOD PLATELETS; CALCIMYCIN; CALCIUM; COLLAGEN; COUMARINS; HUMANS; IONOPHORES; MOLECULAR STRUCTURE; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS;

EID: 1942455448     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2003.12.010     Document Type: Article

References (14)

1. Mazzei M., Balbi A., Roma G., Di Braccio M., Leoncini G., Buzzi E., Maresca M. Eur. J. Med. Chem. 23:1988;237-242.
2. Mazzei M., Sottofattori E., Di Braccio M., Balbi A., Leoncini G., Buzzi E., Maresca M. Eur. J. Med. Chem. 25:1990;617-622.
3. Di Braccio M., Roma G., Leoncini G., Poggi M. Il Farmaco. 50:1995;703-711.
4. Roma G., Di Braccio M., Carrieri A., Grossi G.C., Leoncini G., Signorello M.G., Carotti A. Bioorg. Med. Chem. 11:2003;123-138.
5. Roma G., Di Braccio M., Leoncini G., Aprile B. Il Farmaco. 48:1993;1225-1238.
6. Di Braccio M., Roma G., Leoncini G. Eur. J. Med. Chem. 30:1995;27-38.
7. Roma G., Cinone N., Di Braccio M., Grossi G.C., Leoncini G., Signorello M.G., Carotti A. Bioorg. Med. Chem. 8:2000;751-768.
8. Ermili A., Mazzei M., Roma G., Cacciatore C. Il Farmaco-Ed. Sci. 32:1977;375-387.
9. Leoncini G., Maresca M., Colao C., Buzzi E., Mazzei M., Balbi A. Pharmacol. Res. 23:1991;139-148.
10. Leoncini G., Signorello M.G., Roma G., Di Braccio M. Biochem. Pharmacol. 53:1997;1667-1672.
11. Hermodson M.A., Barker W.M., Link K.P. J. Med. Chem. 14:1971;167-169.
12. Van Dam M.J.D., Kögl F. Rec. Trav. Chim. Pays-Bas. 83:1964;39-49.
13. Leoncini G., Signorello M.G., Bruzzese D., Di Braccio M., Grossi G.C., Roma G. Biochem. Pharmacol. 67:2004;911-918.
14. Born G.V.R. Nature (London). 194:1962;927-929.