Discovery of safety biomarkers for realgar in rat urine using UFLC-IT-TOF/MS and 1H NMR based metabolomics

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 14, 2013, Pages 4811-4822

  Huang, Yin ^a   Tian, Yuan ^a   Li, Geng ^a   Li, Yuanyuan ^a   Yin, Xinjuan ^a   Peng, Can ^a   Xu, Fengguo ^a   Zhang, Zunjian ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Biomarker; Liquid chromatography mass spectrometry .NMR; Metabolomics; Realgar; Urine

Indexed keywords

AMINO ACIDS; BIOMARKERS; DATA HANDLING; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC POLYMERS; RATS;

1H NMR SPECTROSCOPY; AMINO ACID METABOLISM; DATA PROCESSING METHODS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; METABOLOMICS; REALGAR; ULTRA-FAST LIQUID CHROMATOGRAPHY; URINE;

LIQUID CHROMATOGRAPHY;

RATTUS;

ARSENIC DISULFIDE; ORGANOARSENIC DERIVATIVE; PHARMACOLOGICAL BIOMARKER; PROTON; SULFIDE; DIAGNOSTIC AGENT;

ANIMAL; DIAGNOSTIC USE; DOSE RESPONSE; DRUG EFFECTS; DRUG MONITORING; LIQUID CHROMATOGRAPHY; MALE; METABOLOME; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; TANDEM MASS SPECTROMETRY; TOXICITY; URINE; ARTICLE; DRUG EFFECT; METHODOLOGY;

ANIMALS; ARSENICALS; BIOMARKERS, PHARMACOLOGICAL; CHROMATOGRAPHY, LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG MONITORING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; PROTONS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SULFIDES; TANDEM MASS SPECTROMETRY;

EID: 84887265432     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-6842-0     Document Type: Article

References (37)

1. Liu J, Lu Y, Wu Q, Goyer RA, Waalkes MP (2008) Mineral arsenicals in traditional medicines: orpiment, realgar, and arsenolite. J Pharmacol Exp Ther 326:363-368
2. Luo X-Q, Ke Z-Y, Huang L-B, Guan X-Q, Zhang Y-C, Zhang X-L (2009) Improved outcome for Chinese children with acute promyelocytic leukemia: a comparison of two protocols. Pediatr Blood Cancer 53:325-328
3. Hu J, Liu Y-F, Wu C-F et al (2009) Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci U S A 106:3342-3347
4. Zhang Y-N, Sun G-X, Huang Q, Williams PN, Zhu Y-G (2011) A cultural practice of drinking realgar wine leading to elevated urinary arsenic and its potential health risk. Environ Int 37:889-892
5. Lu Y, Shi J, Shi J, Liu J (2011) Safety evaluation of realgar-and cinnabar-containing traditional Chinese medicine. China J Chin Mater Med 36:3402-3405
6. Liang A, Li C, Wang J, Xue B, Li H, Yang B, Wang J, Xie Q, Nilsen OG (2011) Toxicity study of realgar. China J Chin Mater Med 36:1889-1894
7. Koch I, Sylvester S, Lai VWM, Owen A, Reimer KJ, Cullen WR (2007) Bioaccessibility and excretion of arsenic in Niu Huang Jie Du Pian pills. Toxicol Appl Pharmacol 222:357-364
8. Zhang J, Zhang X, Ni Y, Yang X, Li H (2007) Bioleaching of arsenic from medicinal realgar by pure and mixed cultures. Process Biochem 42:1265-1271
9. Liu J, Liang S-X, Lu Y-F, Miao J-W,Wu Q, Shi J-S (2011) Realgar and realgar-containing Liu-Shen-Wan are less acutely toxic than arsenite and arsenate. J Ethnopharmacol 134:26-31
10. Wu J-Z, Ho PC (2004) Speciation of inorganic and methylated arsenic compounds by capillary zone electrophoresis with indirect UV detection. J Chromatogr A 1026:261-270
11. Tse W-P, Cheng CHK, Che C-T, Lin Z-X (2008) Arsenic trioxide, arsenic pentoxide, and arsenic iodide inhibit human keratinocyte proliferation through the induction of apoptosis. J Pharmacol Exp Ther 326:388-394
12. Kaddurah-Daouk R, Kristal BS, Weinshilboum RM (2008) Metabolomics: a global biochemical approach to drug response and disease. Annu Rev Pharmacol Toxicol 48:653-683
13. Zgoda-Pols JR, Chowdhury S, Wirth M, Milburn MV, Alexander DC, Alton KB (2011) Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: investigation of nicotinic acid receptor agonists. Toxicol Appl Pharmacol 255:48-56
14. Wang X, Wang H, Zhang A, Lu X, Sun H, Dong H, Wang P (2012) Metabolomics study on the toxicity of aconite root and its processed products using ultraperformance liquid-chromatography/electrosprayionization synapt high-definition mass spectrometry coupled with pattern recognition approach and ingenuity pathways analysis. J Proteome Res 11:1284-1301
15. RessomHW, Xiao JF, Tuli L et al (2012) Utilization ofmetabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis. Anal Chim Acta 743:90-100
16. Rupérez FJ, Ramos-Mozo P, Teul J et al (2012) Metabolomic study of plasma of patients with abdominal aortic aneurysm. Anal Bioanal Chem 403:1651-1660
17. Huang Y, Tian Y, Zhang Z, Peng C (2012) A HILIC-MS/MS method for the simultaneous determination of seven organic acids in rat urine as biomarkers of exposure to realgar. J Chromatogr B 905:37-42
18. Huo T, Chang B, Zhang Y, Chen Z, Li W, Jiang H (2012) Alteration of amino acid neurotransmitters in brain tissues of immature rats treated with realgar. J Pharm Biomed Anal 57:120-124
19. Wei L, Liao P, Wu H, Li X, Pei F, Li W, Wu Y (2009) Metabolic profiling studies on the toxicological effects of realgar in rats by (1)H NMR spectroscopy. Toxicol Appl Pharmacol 234:314-325
20. Powers R (2009) NMR metabolomics and drug discovery. Magn Reson Chem 47(Suppl 1):S2-S11
21. Keun HC, Ebbels TMD, Antti H et al (2013) Analytical reproducibility in 1H NMR-based metabonomic urinalysis. Chem Res Toxicol 15:1380-1386
22. Dumas M-E, Maibaum EC, Teague C et al (2006) Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study. Anal Chem 78:2199-2208
23. Masson P, Spagou K, Nicholson JK,Want EJ (2011) Technical and biological variation in UPLC-MS-based untargeted metabolic profiling of liver extracts: application in an experimental toxicity study on galactosamine. Anal Chem 83:1116-1123
24. Curzon G, Knott PJ (1974) Effects on plasma and brain tryptophan in the rat of drugs and hormones that influence the concentration of unesterified fatty acid in the plasma. Br J Pharmacol 50:197-204
25. Liu X, Xue X, Gong L, Qi X, WU Y, Xing G, Luan Y, Xiao Y, Wu X, LI Y 1H NMR-based metabolomic analysis of triptolideinduced toxicity in liver-specific cytochrome P450 reductase knockout mice. Metabolomics 1-12
26. Fukuda S, Nakanishi Y, Chikayama E, Ohno H, Hino T, Kikuchi J (2009) Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping. PLoS One 4:e4893
27. Zhou L, Ding L, Yin P, Lu X, Wang X, Niu J, Gao P, Xu G (2012) Serum metabolic profiling study of hepatocellular carcinoma infected with hepatitis B or hepatitis C virus by using liquid chromatography-mass spectrometry. J Proteome Res 11:5433-5442
28. Ng JC, Wang JP, Zheng B, Zhai C, Maddalena R, Liu F, Moore MR (2005) Urinary porphyrins as biomarkers for arsenic exposure among susceptible populations in Guizhou province, China. Toxicol Appl Pharmacol 206:176-184
29. Maker JR, Struempler A, Chaykin S (1963) A comparative study of trimethylamine-N-oxide biosynthesis. Biochim Biophys Acta 71:58-64
30. Krupp D, Doberstein N, Shi L, Remer T (2012) Hippuric acid in 24-hour urine collections is a potential biomarker for fruit and vegetable consumption in healthy children and adolescents. J Nutr 142:1314-1320
31. Wu J, Shao Y, Liu J, Chen G, Ho PC (2011) The medicinal use of realgar (As4S4) and its recent development as an anticancer agent. J Ethnopharmacol 135:595-602
32. Richardson IW, Szerb JC (1974) The release of labelled acetylcholine and choline from cerebral cortical slices stimulated electrically. Br J Pharmacol 52:499-507
33. Ye H-Q, Gan L, Yang X-L, Xu H-B (2006) Membrane-associated cytotoxicity induced by realgar in promyelocytic leukemia HL-60 cells. J Ethnopharmacol 103:366-371
34. Akter KF, Owens G, Davey DE, Naidu R (2005) Arsenic speciation and toxicity in biological systems. Rev Environ Contam Toxicol 184:97-149
35. Beyoǧlu D, Idle JR (2012) The glycine deportation system and its pharmacological consequences. Pharmacol Ther 135:151-167
36. Tabatabaie L, Klomp LW, Berger R, de Koning TJ (2010) L-Serine synthesis in the central nervous system: a review on serine deficiency disorders. Mol Genet Metab 99:256-262
37. Chan ECY, Pasikanti KK, Nicholson JK (2011) Global urinary metabolic profiling procedures using gas chromatography-mass spectrometry. Nat Protoc 6:1483-1499