Serum metabolic profiling study of hepatocellular carcinoma infected with hepatitis B or hepatitis C virus by using liquid chromatography-mass spectrometry

Journal of Proteome Research

Volumn 11, Issue 11, 2012, Pages 5433-5442

  Zhou, Lina ^a   Ding, Lili ^b   Yin, Peiyuan ^a   Lu, Xin ^a   Wang, Xiaomei ^b   Niu, Junqi ^b   Gao, Pujun ^b   Xu, Guowang ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b JILIN UNIVERSITY   (China)

Author keywords

arachidonic acid; hepatitis B; hepatitis C; hepatocellular carcinoma; liver cirrhosis; lysophosphatidylcholine; metabolic profiling

Indexed keywords

ARACHIDONIC ACID; LYSOPHOSPHATIDYLCHOLINE; POLYUNSATURATED FATTY ACID;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD ANALYSIS; CHRONIC INFLAMMATION; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DNA FINGERPRINTING; FEMALE; HEPATITIS B; HEPATITIS C; HUMAN; LIQUID CHROMATOGRAPHY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

CARCINOMA, HEPATOCELLULAR; CHROMATOGRAPHY, LIQUID; FEMALE; HEPACIVIRUS; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; MALE; MASS SPECTROMETRY; MIDDLE AGED;

HEPATITIS B VIRUS; HEPATITIS C VIRUS;

EID: 84868323261     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr300683a     Document Type: Article

References (50)

1. Parkin, D. M.; Bray, F.; Ferlay, J.; Pisani, P. Global cancer statistics, 2002 CA. Cancer J. Clin. 2005, 55 (2) 74-108
2. Chen, J. G.; Zhang, S. W. Liver cancer epidemic in China: past, present and future Semin. Cancer Biol. 2011, 21 (1) 59-69
3. Kuper, H.; Adami, H. O.; Trichopoulos, D. Infections as a major preventable cause of human cancer J. Intern. Med. 2000, 248 (3) 171-183
4. El-Serag, H. B.; Marrero, J. A.; Rudolph, L.; Reddy, K. R. Diagnosis and treatment of hepatocellular carcinoma Gastroenterology 2008, 134 (6) 1752-1763
5. Chen, L.; Ho, D. W. Y.; Lee, N. P. Y.; Sun, S.; Lam, B.; Wong, K.-F.; Yi, X.; Lau, G. K.; Ng, E. W. Y.; Poon, T. C. W.; Lai, P. B. S.; Cai, Z.; Peng, J.; Leng, X.; Poon, R. T. P.; Luk, J. M. Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker Ann. Surg. Oncol. 2010, 17 (9) 2518-2525
6. Colli, A.; Fraquelli, M.; Casazza, G.; Massironi, S.; Colucci, A.; Conte, D.; Duca, P. Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: a systematic review Am. J. Gastroenterol. 2006, 101 (3) 513-523
7. Nicholson, J. K.; Lindon, J. C.; Holmes, E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 1999, 29 (11) 1181-1189
8. van der Greef, J.; Stroobant, P.; van der Heijden, R. The role of analytical sciences medical systems biology Curr. Opin. Chem. Biol. 2004, 8 (5) 559-565
9. Gao, H. C.; Lu, Q.; Liu, X.; Cong, H.; Zhao, L. C.; Wang, H. M.; Lin, D. H. Application of H-1 NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis Cancer Sci. 2009, 100 (4) 782-785
10. Yin, P.; Wan, D.; Zhao, C.; Chen, J.; Zhao, X.; Wang, W.; Lu, X.; Yang, S.; Gu, J.; Xu, G. A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry Mol. BioSyst. 2009, 5 (8) 868
11. Soga, T.; Sugimoto, M.; Honma, M.; Mori, M.; Igarashi, K.; Kashikura, K.; Ikeda, S.; Hirayama, A.; Yamamoto, T.; Yoshida, H. Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease J. Hepatol. 2011, 55 (4) 896-905
12. Wang, B.; Chen, D.; Chen, Y.; Hu, Z.; Cao, M.; Xie, Q.; Chen, Y.; Xu, J.; Zheng, S.; Li, L. Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry J. Proteome Res. 2012, 11 (2) 1217-1227
13. Chen, F.; Xue, J.; Zhou, L.; Wu, S.; Chen, Z. Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method Anal. Bioanal. Chem. 2011, 401 (6) 1899-1904
14. Shariff, M. I. F.; Gomaa, A. I.; Cox, I. J.; Patel, M.; Williams, H. R. T.; Crossey, M. M. E.; Thillainayagam, A. V.; Thomas, H. C.; Waked, I.; Khan, S. A.; Taylor-Robinson, S. D. Urinary metabolic biomarkers of hepatocellular carcinoma in an Egyptian population: a validation study J. Proteome Res. 2011, 10 (4) 1828-1836
15. Nguyen, M. H.; Keeffe, E. B. Chronic hepatitis B and hepatitis C in Asian Americans Rev. Gastroenterol. Disord. 2003, 3 (3) 125-34
16. Zhao, X.; Fritsche, J.; Wang, J.; Chen, J.; Rittig, K.; Schmitt-Kopplin, P.; Fritsche, A.; Häring, H.-U.; Schleicher, E. D.; Xu, G.; Lehmann, R. Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits Metabolomics 2010, 6 (3) 362-374
17. Chen, J.; Zhang, X.; Cao, R.; Lu, X.; Zhao, S.; Fekete, A.; Huang, Q.; Schmitt-Kopplin, P.; Wang, Y.; Xu, Z.; Wan, X.; Wu, X.; Zhao, N.; Xu, C.; Xu, G. Serum 27-nor-5β-cholestane-3,7,12,24,25 pentol glucuronide discovered by metabolomics as potential diagnostic biomarker for epithelium ovarian cancer J. Proteome Res. 2011, 10 (5) 2625-2632
18. Smith, C. A.; Want, E. J.; O'Maille, G.; Abagyan, R.; Siuzdak, G. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification Anal. Chem. 2006, 78 (3) 779-787
19. Gika, H. G.; Theodoridis, G. A.; Wingate, J. E.; Wilson, I. D. Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine J. Proteome Res. 2007, 6 (8) 3291-3303
20. Chen, J.; Zhao, X.; Fritsche, J.; Yin, P.; Schmitt-Kopplin, P.; Wang, W.; Lu, X.; Häring, H.-U.; Schleicher, E. D.; Lehmann, R.; Xu, G. Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information Anal. Chem. 2008, 80 (4) 1280-1289
21. Takikawa, O.; Kuroiwa, T.; Yamazaki, F.; Kido, R. Mechanism of interferon-gamma action-characterization of indoleamine 2, 3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity J. Biol. Chem. 1988, 263 (4) 2041-2048
22. Hwu, P.; Du, M. X.; Lapointe, R.; Do, M.; Taylor, M. W.; Young, H. A. Indoleamine 2, 3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation J. Immunol. 2000, 164 (7) 3596-3599
23. Uyttenhove, C.; Pilotte, L.; Théate, I.; Stroobant, V.; Colau, D.; Parmentier, N.; Boon, T.; Van den Eynde, B. J. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2, 3-dioxygenase Nat. Med. 2003, 9 (10) 1269-1274
24. Kudo, Y.; Boyd, C.; Sargent, I.; Redman, C. Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation J. Physiol. 2001, 535 (1) 207-215
25. Frumento, G.; Rotondo, R.; Tonetti, M.; Ferrara, G. B. T cell proliferation is blocked by indoleamine 2,3-dioxygenase Transplant. Proc. 2001, 33 (1) 428-430
26. Zhou, L.; Wang, Q.; Yin, P.; Xing, W.; Wu, Z.; Chen, S.; Lu, X.; Zhang, Y.; Lin, X.; Xu, G. Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases Anal. Bioanal. Chem. 2012, 403 (1) 203-213
27. Taylor, L. A.; Arends, J.; Hodina, A. K.; Unger, C.; Massing, U. Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status Lipids Health Dis. 2007, 6, 17 10.1186/1476-511X-6-17
28. Lands, W. E. M. Metabolism of glycerolipids. 2. Enzymatic acylation of lysolecithin J. Biol. Chem. 1960, 235 (8) 2233-2237
29. Macdonald, J. I. S.; Sprecher, H. Phospholipid fatty-acid remodeling in mammalian-cells Biochim. Biophys. Acta 1991, 1084 (2) 105-121
30. Eberhart, C. E.; Dubois, R. N. Eicosanoids and the gastrointestinal-tract Gastroenterology 1995, 109 (1) 285-301
31. Clarke, G.; Fitzgerald, P.; Hennessy, A. A.; Cassidy, E. M.; Quigley, E. M. M.; Ross, P.; Stanton, C.; Cryan, J. F.; Dinan, T. G. Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome J. Lipid Res. 2009, 51 (5) 1186-1192
32. Hung, N. D.; Kim, M. R.; Sok, D.-E. Anti-inflammatory action of arachidonoyl lysophosphatidylcholine or 15-hydroperoxy derivative in zymosan A-induced peritonitis Prostaglandins Other Lipid Mediat. 2009, 90 (3-4) 105-111
33. Karin, M.; Greten, F. R. NF-kappa B: linking inflammation and immunity to cancer development and progression Nat. Rev. Immunol. 2005, 5 (10) 749-759
34. Karin, M.; Lawrence, T.; Nizet, V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer Cell 2006, 124 (4) 823-835
35. Chen, C.; Shah, Y. M.; Morimura, K.; Krausz, K. W.; Miyazaki, M.; Richardson, T. A.; Morgan, E. T.; Ntambi, J. M.; Idle, J. R.; Gonzalez, F. J. Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis Cell Metab. 2008, 7 (2) 135-147
36. Dong, J.; Cai, X.; Zhao, L.; Xue, X.; Zou, L.; Zhang, X.; Liang, X. Lysophosphatidylcholine profiling of plasma: discrimination of isomers and discovery of lung cancer biomarkers Metabolomics 2010, 6 (4) 478-488
37. Zhao, Z.; Xiao, Y.; Elson, P.; Tan, H.; Plummer, S. J.; Berk, M.; Aung, P. P.; Lavery, I. C.; Achkar, J. P.; Li, L.; Casey, G.; Xu, Y. Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancer J. Clin. Oncol. 2007, 25 (19) 2696-2701
38. Patterson, A. D.; Maurhofer, O.; Beyoglu, D.; Lanz, C.; Krausz, K. W.; Pabst, T.; Gonzalez, F. J.; Dufour, J.-F.; Idle, J. R. Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling Cancer Res. 2011, 71 (21) 6590-6600
39. Hung, N. D.; Sok, D.-E.; Kim, M. R. Prevention of 1-palmitoyl lysophosphatidylcholine-induced inflammation by polyunsaturated acyl lysophosphatidylcholine Inflamm. Res. 2012, 61 (5) 473-383
40. Mehta, D. Lysophosphatidylcholine: an enigmatic lysolipid Am. J. Physiol. Lung Cell. Mol. Physiol. 2005, 289 (2) L174-L175
41. Ojala, P. J.; Hirvonen, T. E.; Hermansson, M.; Somerharju, P.; Parkkinen, J. Acyl chain-dependent effect of lysophosphatidylcholine on human neutrophils J. Leukocyte Biol. 2007, 82 (6) 1501-1509
42. Huang, L. S.; Hung, N. D.; Sok, D.-E.; Kim, M. R. Lysophosphatidylcholine containing docosahexaenoic acid at the sn-1 position is anti-inflammatory Lipids 2010, 45 (3) 225-236
43. Dobrzyn, P.; Dobrzyn, A. Stearoyl-CoA desaturase: a new therapeutic target of liver steatosis Drug Dev. Res. 2006, 67 (8) 643-650
44. Stock, C.; Schilling, T.; Schwab, A.; Eder, C. Lysophosphatidylcholine stimulates IL-1 beta release from microglia via a P2X(7) receptor-independent mechanism J. Immunol. 2006, 177 (12) 8560-8568
45. Liu-Wu, Y.; Hurt-Camejo, E.; Wiklund, O. Lysophosphatidylcholine induces the production of IL-1 beta by human monocytes Atherosclerosis 1998, 137 (2) 351-357
46. Lum, H.; Qiao, J.; Walter, R. J.; Huang, F.; Subbaiah, P. V.; Kim, K. S.; Holian, O. Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells Am. J. Physiol. Heart Circ. Physiol 2003, 285 (4) H1786-H1789
47. Hiley, C. R.; Hoi, P. M. Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? Cardiovasc. Drug Rev. 2007, 25 (1) 46-60
48. van der Poorten, D.; Shahidi, M.; Tay, E.; Sesha, J.; Tran, K.; McLeod, D.; Milliken, J. S.; Ho, V.; Hebbard, L. W.; Douglas, M. W.; George, J. Hepatitis C virus induces the cannabinoid receptor 1 PLoS One 2010, 5 (9) e12841
49. Mukhopadhyay, B.; Cinar, R.; Yin, S.; Liu, J.; Tam, J.; Godlewski, G.; Harvey-White, J.; Mordi, I.; Cravatt, B. F.; Lotersztajn, S.; Gao, B.; Yuan, Q.; Schuebel, K.; Goldman, D.; Kunos, G. Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB(1)) receptors in the regenerating liver Proc. Natl. Acad. Sci. U.S.A. 2011, 108 (15) 6323-6328
50. Xie, C.; Liu, G.; Liu, J.; Huang, Z.; Wang, F.; Lei, X.; Wu, X.; Huang, S.; Zhong, D.; Xu, X. Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells Oncol. Lett. 2012, 4, 403-407