Pretreatment of liver grafts in vivo by γ-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat

Annals of Transplantation

Volumn 18, Issue 1, 2013, Pages 299-313

  Hori, Tomohide ^a,b   Gardner, Lindsay B ^a   Hata, Toshiyuki ^a,b   Chen, Feng ^a   Baine, Ann Marie T ^a   Uemoto, Shinji ^b   Nguyen, Justin H ^a  

^a MAYO CLINIC   (United States)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cold ischemia; Free radicals; Oxidative stress; Reperfusion injury; Warm reperfusion

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 HYDROXYNONENAL; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ATR PROTEIN; BICUCULLINE; BILIRUBIN; CASPASE 3; HISTONE H2AX; MUSCIMOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BLOOD CLOTTING; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; GRAFT FAILURE; HISTOPATHOLOGY; IMMUNOHISTOLOGY; INTERNATIONAL NORMALIZED RATIO; LAPAROTOMY; LIPID PEROXIDATION; LIVER TRANSPLANTATION; MALE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; POSTOPERATIVE CARE; PROTEIN DETERMINATION; PROTHROMBIN TIME; RAT; REPERFUSION INJURY; SURVIVAL RATE; WESTERN BLOTTING;

ANIMALS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; BICUCULLINE; COLD ISCHEMIA; DNA REPAIR; GABA AGONISTS; GABA ANTAGONISTS; HISTONES; LIPID PEROXIDATION; LIVER TRANSPLANTATION; MALE; MUSCIMOL; OXIDATIVE STRESS; RATS; RATS, INBRED LEW; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WARM ISCHEMIA;

EID: 84887249069     PISSN: 14259524     EISSN: None     Source Type: Journal    
DOI: 10.12659/AOT.883955     Document Type: Article

References (53)

1. Acuna Castroviejo D, Lopez LC, Escames G et al: Melatonin-mitochondria interplay in health and disease. Curr Top Med Chem, 2011; 11: 221-40
2. Ghosh N, Ghosh R, Mandal SC: Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease. Free Radic Res, 2011; 45: 888-905
3. Turan B: Role of antioxidants in redox regulation of diabetic cardiovascular complications. Curr Pharm Biotechnol, 2010; 11: 819-36
4. Pamenter ME, Hogg DW, Ormond J et al: Endogenous GABAA and GABAB receptor-mediated electrical suppression is critical to neuronal anoxia tolerance. Proc Natl Acad Sci USA, 2011; 108: 11274-79
5. Andang M, Hjerling-Leffler J, Moliner A et al: Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation. Nature, 2008; 451: 460-64
6. Ferreira JM, Burnett AL, Rameau GA: Activitydependent regulation of surface glucose transporter-3. J Neurosci, 2011; 31: 1991-99
7. Hirooka Y, Kishi T, Sakai K et al: Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension. Am J Physiol Regul Integr Comp Physiol, 2011; 300: R818-26
8. Kurt S, Crook JM, Ohl FW et al: Differential effects of iontophoretic in vivo application of the GABAA-antagonists bicuculline and gabazine in sensory cortex. Hear Res, 2006; 212: 224-35
9. Gong Y, Zhang M, Cui L, Minuk GY: Sequence and chromosomal assignment of a human novel cDNA: similarity to gamma-aminobutyric acid transporter. Can J Physiol Pharmacol, 2001; 79: 977-84
10. Norikura T, Kojima-Yuasa A, Opare Kennedy D, Matsui-Yuasa I: Protective effect of gammaaminobutyric acid (GABA) against cytotoxicity of ethanol in isolated rat hepatocytes involves modulations in cellular polyamine levels. Amino Acids, 2007; 32: 419-23
11. Chu XY, Liang Y, Cai X et al: Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters. Pharm Res, 2009; 26: 459-68
12. Biju MP, Pyroja S, Rajeshkumar NV, Paulose CS: Hepatic GABA(A) receptor functional regulation during rat liver cell proliferation. Hepatol Res, 2001; 21: 136-46
13. nd ed.). East Norwalk (CT): Appleton & Lange, 1995; 297-321
14. Abdennebi HB, Zaouali MA, Alfany-Fernandez I et al: How to protect liver graft with nitric oxide. World J Gastroenterol, 2011; 17: 2879-89
15. Selzner N, Rudiger H, Graf R, Clavien PA: Protective strategies against ischemic injury of the liver. Gastroenterology, 2003; 125: 917-36
16. de Rougemont O, Lehmann K, Clavien PA: Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver. Liver Transpl, 2009; 15: 1172-82
17. Hori T, Nguyen JH, Zhao X et al: Comprehensive and innovative techniques for liver transplantation in rats: a surgical guide. World J Gastroenterol, 2010; 16: 3120-32
18. Hori T, Uemoto S, Zhao X et al: Surgical guide including innovative techniques for orthotopic liver transplantation in the rat: Key techniques and pitfalls in whole and split liver grafts. Annals of Gastroenterology, 2010; 13: 270-95
19. Goodchild AK, Van Deurzen BT, Sun QJ et al: Spinal GABAA receptors do not mediate the sympathetic baroreceptor reflex in the rat. Am J Physiol Regul Integr Comp Physiol, 2000; 279: R320-31
20. Padrissa-Altes S, Zaouali MA, Franco-Gou R et al: Matrix metalloproteinase 2 in reduced-size liver transplantation: beyond the matrix. Am J Transplant, 2010; 10: 1167-77
21. Ma ZY, Qian JM, Rui XH et al: Inhibition of matrix metalloproteinase-9 attenuates acute smallfor-size liver graft injury in rats. Am J Transplant, 2010; 10: 784-95
22. Defamie V, Laurens M, Patrono D et al: Matrix metalloproteinase inhibition protects rat livers from prolonged cold ischemia-warm reperfusion injury. Hepatology, 2008; 47: 177-85
23. Awasthi YC, Sharma R, Sharma A et al: Selfregulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radic Biol Med, 2008; 45: 111-18
24. Voulgaridou GP, Anestopoulos I, Franco R et al: DNA damage induced by endogenous aldehydes: current state of knowledge. Mutat Res, 2011; 711: 13-27
25. Kim J, Wong PK: Loss of ATM impairs proliferation of neural stem cells through oxidative stress-mediated p38 MAPK signaling. Stem Cells, 2009; 27: 1987-98
26. Irarrazabal CE, Liu JC, Burg MB, Ferraris JD: ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci USA, 2004; 101: 8809-14
27. Yuan J, Adamski R, Chen J: Focus on histone variant H2AX: to be or not to be. FEBS Lett, 2010; 584: 3717-24
28. Rogakou EP, Pilch DR, Orr AH et al: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem, 1998; 273: 5858-68
29. Burma S, Chen BP, Murphy M et al: ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem, 2001; 276: 42462-67
30. Rogakou EP, Boon C, Redon C, Bonner WM: Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol, 1999; 146: 905-16
31. Fernando RN, Eleuteri B, Abdelhady S et al: Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells. Proc Natl Acad Sci USA, 2011; 108: 5837-42
32. Maruyama S, Shibata R, Ohashi K et al: Adiponectin ameliorates doxorubicin-induced cardiotoxicity through an Akt dependent mechanism. J Biol Chem, 2011; 286: 32790-800
33. Sanchez Y, Amran D, de Blas E, Aller P: Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation. Biochem Pharmacol, 2009; 77: 384-96
34. Franke TF, Kaplan DR, Cantley LC: PI3K: downstream AKTion blocks apoptosis. Cell, 1997; 88: 435-37
35. Burgering BM, Coffer PJ: Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature, 1995; 376: 599-602
36. Franke TF, Yang SI, Chan TO et al: The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell, 1995; 81: 727-36
37. Kim D, Chung J: Akt: versatile mediator of cell survival and beyond. J Biochem Mol Biol, 2002; 35: 106-15
38. Datta SR, Dudek H, Tao X et al: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 1997; 91: 231-41
39. Lee JE, Kang JS, Ki YW et al: Akt/GSK3beta signaling is involved in fipronil-induced apoptotic cell death of human neuroblastoma SHSY5Y cells. Toxicol Lett, 2011; 202: 133-41
40. Khalil A, Morgan RN, Adams BR et al: ATMdependent ERK signaling via AKT in response to DNA double-strand breaks. Cell Cycle, 2011; 10: 481-91
41. Xu J, Li C, Yin XH, Zhang GY: Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/ Akt pathway inhibiting the ASK1-JNK cascade. Neuropharmacology, 2008; 54: 1029-40
42. Cesetti T, Fila T, Obernier K et al: GABA(A) Receptor Signaling Induces Osmotic Swelling and Cell Cycle Activation of Neonatal Prominin(+) Precursors. Stem Cells, 2011; 29: 307-19
43. Cescon M, Carini R, Grazi G et al: Variable activation of phosphoinositide 3-kinase influences the response of liver grafts to ischemic preconditioning. J Hepatol, 2009; 50: 937-47
44. Dal Ponte C, Alchera E, Follenzi A et al: Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury. Liver Transpl, 2011; 17: 474-82
45. Haga S, Ozaki M, Inoue H et al: The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology, 2009; 49: 204-14
46. Majid DS, Kopkan L: Nitric oxide and superoxide interactions in the kidney and their implication in the development of salt-sensitive hypertension. Clin Exp Pharmacol Physiol, 2007; 34: 946-52
47. Tejada S, Roca C, Sureda A et al: Antioxidant response analysis in the brain after pilocarpine treatments. Brain Res Bull, 2006; 69: 587-92
48. Zhou J, Li Y, Yan G et al: Protective Role of Taurine Against Morphine-Induced Neurotoxicity in C6 Cells via Inhibition of Oxidative Stress. Neurotox Res, 2011; 20: 334-42
49. Wright G, Reichenbecher V, Green T et al: Paraquat inhibits the processing of human manganese-dependent superoxide dismutase by SF-9 insect cell mitochondria. Exp Cell Res, 1997; 234: 78-84
50. Rehman H, Connor HD, Ramshesh VK et al: Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation, 2008; 85: 1322-31
51. Maulik N, Das DK: Emerging potential of thioredoxin and thioredoxin interacting proteins in various disease conditions. Biochim Biophys Acta, 2008; 1780: 1368-82
52. Hori T, Gardner LB, Chen F et al: Liver graft pretreated in vivo or ex vivo by g-aminobutyric acid receptor regulation. J Surg Res, 2013; 182(1): 166-75
53. Gardner LB, Hori T, Chen F et al: Effect of specific activation of g-aminobutyric acid receptor in vivo on oxidative stress-induced damage after extended hepatectomy. Hepatol Res, 2012; 42: 1131-40