Adiponectin ameliorates doxorubicin-induced cardiotoxicity through Akt protein-dependent mechanism

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32790-32800

  Maruyama, Sonomi ^a,b   Shibata, Rei ^a   Ohashi, Koji ^a   Ohashi, Taiki ^a   Daida, Hiroyuki ^b   Walsh, Kenneth ^c   Murohara, Toyoaki ^a   Ouchi, Noriyuki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRAL VECTORS; ADIPONECTIN; AKT ACTIVATION; AKT PHOSPHORYLATION; APOPTOTIC ACTIVITY; CARDIAC MYOCYTES; CARDIAC TOXICITY; CARDIOMYOCYTES; CARDIOTOXICITY; CONTRACTILE DYSFUNCTION; DOXORUBICIN; INHIBITORY EFFECT; INTRAPERITONEALLY; KNOCK OUTS; LEFT VENTRICLES; MOLECULAR MECHANISM; MYOCARDIAL APOPTOSIS; PATHOLOGICAL RESPONSE; PRE-TREATMENT; RAT NEONATAL CARDIOMYOCYTES; RECEPTOR ANTAGONISTS; SINGLE-DOSE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATES; WILD TYPES;

ACTIVATION ANALYSIS; ANTIBODIES; CELL DEATH; NUTRITION; PHOSPHORYLATION; SIGNALING;

MAMMALS;

ADENOVIRUS VECTOR; ADIPONECTIN; CALRETICULIN; DOXORUBICIN; ENZYME INHIBITOR; PROTEIN ANTIBODY; PROTEIN INHIBITOR; PROTEIN KINASE B; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARDIOTOXICITY; CELL SURVIVAL; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG INDUCED DISEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GAIN OF FUNCTION MUTATION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE; HEART MUSCLE CELL; INTRACELLULAR SIGNALING; LOSS OF FUNCTION MUTATION; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADIPONECTIN; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, NEUTRALIZING; APOPTOSIS; CALCINEURIN; CARDIOTOXINS; CELL SURVIVAL; CELLS, CULTURED; DOXORUBICIN; ENZYME ACTIVATION; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTORS, LDL; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

MUS; RATTUS;

EID: 80052772398     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.245985     Document Type: Article

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