Kinetic framework of spindle assembly checkpoint signalling

Nature Cell Biology

Volumn 15, Issue 11, 2013, Pages 1370-1377

  Dick, Amalie E ^a,b,c   Gerlich, Daniel W ^a,b,c  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b ETH ZURICH   (Switzerland)

^c MARINE BIOLOGICAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; ANAPHASE PROMOTING COMPLEX; HISTONE H2B; PROTEIN MAD2;

ANAPHASE; ARTICLE; CENTROMERE; CONTROLLED STUDY; HELA CELL; M PHASE CELL CYCLE CHECKPOINT; METAPHASE; MICROTUBULE; MITOSIS SPINDLE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CHROMOSOMES, HUMAN; HUMANS; KINETOCHORES; M PHASE CELL CYCLE CHECKPOINTS; SIGNAL TRANSDUCTION; SPINDLE APPARATUS;

EID: 84887235321     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2842     Document Type: Article

References (37)

1. Musacchio, A. & Salmon, E. D. The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell Biol. 8, 379-393 (2007). (Pubitemid 46643240)
2. Lara-Gonzalez, P., Westhorpe, F. G. & Taylor, S. S. The spindle assembly checkpoint. Curr. Biol. 22, R966-980 (2012).
3. Kitajima, T. S., Ohsugi, M. & Ellenberg, J. Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes. Cell 146, 568-581 (2011).
4. Magidson, V. et al. The spatial arrangement of chromosomes during prometaphase facilitates spindle assembly. Cell 146, 555-567 (2011).
5. Lampson, M. A. & Cheeseman, I. M. Sensing centromere tension: aurora B and the regulation of kinetochore function. Trends Cell Biol. 21, 133-140 (2011).
6. Rieder, C. L., Cole, R. W., Khodjakov, A. & Sluder, G. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J. Cell Biol. 130, 941-948 (1995).
7. Brito, D. A. & Rieder, C. L. Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr. Biol. 16, 1194-1200 (2006). (Pubitemid 43867292)
8. Rieder, C. L. & Maiato, H. Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Dev. Cell 7, 637-651 (2004). (Pubitemid 39462685)
9. Manchado, E. et al. Targeting mitotic exit leads to tumor regression in vivo: modulation by Cdk1, Mastl, and the PP2A/B55alpha, delta phosphatase. Cancer Cell 18, 641-654 (2010).
10. Gascoigne, K. E. & Taylor, S. S. How do anti-mitotic drugs kill cancer cells? J. Cell Sci. 122, 2579-2585 (2009).
11. Huang, H. C., Shi, J., Orth, J. D. & Mitchison, T. J. Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell 16, 347-358 (2009).
12. Yang, Z., Kenny, A. E., Brito, D. A. & Rieder, C. L. Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J. Cell Biol. 186, 675-684 (2009).
13. Reddy, S. K., Rape, M., Margansky, W. A. & Kirschner, M. W. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature 446, 921-925 (2007). (Pubitemid 46633168)
14. Nilsson, J., Yekezare, M., Minshull, J. & Pines, J. The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nat. Cell Biol. 10, 1411-1420 (2008).
15. Uzunova, K. et al. APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat. Struct. Mol. Biol. 19, 1116-1123 (2012).
16. Mansfeld, J., Collin, P., Collins, M. O., Choudhary, J. S. & Pines, J. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Nat. Cell Biol. 13, 1234-1243 (2011).
17. Foster, S. A. & Morgan, D. O. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol. Cell 47, 921-932 (2012).
18. Varetti, G., Guida, C., Santaguida, S., Chiroli, E. & Musacchio, A. Homeostatic control of mitotic arrest. Mol. Cell 44, 710-720 (2011).
19. Waters, J. C., Chen, R. H., Murray, A. W. & Salmon, E. D. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell Biol. 141, 1181-1191 (1998). (Pubitemid 28265612)
20. Lenart, P. et al. The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr. Biol. 17, 304-315 (2007).
21. Liu, D., Davydenko, O. & Lampson, M. A. Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing. J. Cell Biol. 198, 491-499 (2012).
22. Kapoor, T. M. et al. Chromosomes can congress to the metaphase plate before biorientation. Science 311, 388-391 (2006). (Pubitemid 43132665)
23. Stevens, D., Gassmann, R., Oegema, K. & Desai, A. Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest. PLoS One 6, e22969 (2011).
24. Hagting, A. et al. Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J. Cell Biol. 157, 1125-1137 (2002). (Pubitemid 34847784)
25. Held, M. et al. Cell Cognition: time-resolved phenotype annotation in high-throughput live cell imaging. Nat. Methods 7, 747-754 (2010).
26. Vazquez-Novelle, M. D. & Petronczki, M. Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase. Curr. Biol. 20, 1402-1407 (2010).
27. Mirchenko, L. & Uhlmann, F. Sli15(INCENP) dephosphorylation prevents mitotic checkpoint reengagement due to loss of tension at anaphase onset. Curr. Biol. 20, 1396-1401 (2010).
28. Gerlich, D., Koch, B., Dupeux, F., Peters, J. M. & Ellenberg, J. Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication. Curr. Biol. 16, 1571-1578 (2006). (Pubitemid 44142999)
29. Shindo, N., Kumada, K. & Hirota, T. Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition. Dev. Cell 23, 112-123 (2012).
30. Gordon, D. J., Resio, B. & Pellman, D. Causes and consequences of aneuploidy in cancer. Nat. Rev. Genet. 13, 189-203 (2012).
31. Holland, A. J. & Cleveland, D. W. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat. Rev. Mol. Cell Biol. 10, 478-487 (2009).
32. Cimini, D. et al. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J. Cell Biol. 153, 517-527 (2001). (Pubitemid 34280139)
33. Thompson, S. L. & Compton, D. A. Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell Biol. 180, 665-672 (2008). (Pubitemid 351397764)
34. Glover, D. M. Mitosis in the Drosophila embryofiin and out of control. Trends Genet. 7, 125-132 (1991). (Pubitemid 121001910)
35. Sluder, G. Role of spindle microtubules in the control of cell cycle timing. J. Cell Biol. 80, 674-691 (1979). (Pubitemid 9136041)
36. Schmitz, M. H. & Gerlich, D. W. Automated live microscopy to study mitotic gene function in fluorescent reporter cell lines. Methods Mol. Biol. 545, 113-134 (2009).
37. Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676-682 (2012).