Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase

Cell Research

Volumn 23, Issue 11, 2013, Pages 1296-1309

  Xu, Shutong ^a,b   Li, Wenjing ^a,b   Zhu, Junjun ^a,b   Wang, Rong ^a,b   Li, Zheng ^a,b   Xu, Guo Liang ^a   Ding, Jianping ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

catalytic mechanism; crystal structure; decarboxylase; DNA decarboxylation; DNA demethylation; pyrimidine metabolism; thymidine salvage pathway

Indexed keywords

CORDYCEPS; CORDYCEPS MILITARIS; FUNGI; MAMMALIA; METARHIZIUM ANISOPLIAE;

CARBOXYLYASE; DNA; ISOOROTATE DECARBOXYLASE; URACIL;

ANALOGS AND DERIVATIVES; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CORDYCEPS; DECARBOXYLATION; ENZYMOLOGY; GENETICS; METABOLISM; METARHIZIUM; MUTATION; X RAY CRYSTALLOGRAPHY;

BIOCATALYSIS; CARBOXY-LYASES; CORDYCEPS; CRYSTALLOGRAPHY, X-RAY; DECARBOXYLATION; DNA; METARHIZIUM; MODELS, MOLECULAR; MUTATION; URACIL;

EID: 84887231258     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2013.107     Document Type: Article

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