In vitro release testing of PLGA microspheres with Franz diffusion cells

Dissolution Technologies

Volumn 19, Issue 2, 2012, Pages 6-11

  Herrera, Laura C ^a   Tesoriero, María V Defain ^a   Hermida, Laura G ^a  

^a INSTITUTO NACIONAL DE TECNOLOGÍA INDUSTRIAL   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

LEUPRORELIN; PHOSPHATE BUFFERED SALINE; POLYGLACTIN;

ARTICLE; DIALYSIS MEMBRANE; DIFFUSION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; EMULSION; EVAPORATION; IN VITRO STUDY; MOLECULAR WEIGHT;

EID: 84862676571     PISSN: 1521298X     EISSN: None     Source Type: Journal    
DOI: 10.14227/DT190212P6     Document Type: Article

References (28)

1. Martinez, M.; Rathbone, M.; Burgess, D.; Huynh, M. In vitro and in vivo considerations associated with parenteral sustained release products: A review based upon information presented and points expressed at the 2007 Controlled Release Society Annual Meeting. J. Control. Release 2008, 129 (2), 79-87.
2. Rathbone, M. J.; Martinez, M. N.; Huynh, M.; Burgess, D. J. CPS/AAPS Joint Workshop on Critical Variables in the In Vitro and In Vivo Performance of Parenteral Sustained-Release Products. Dissolution Technol. 2009, 16 (2), 55-56.
3. Zolnik, B. S.; Leary, P. E.; Burgess, D. J. Elevated temperature accelerated release testing of PLGA microspheres. J. Control. Release 2006, 112 (3), 293-300.
4. The United States Pharmacopeia and National Formulary USP 32-NF 27; The United States Pharmacopeial Convention, Inc.: Rockville, MD, 2009.
5. DŚouza, S., De Luca, P. Development of a dialysis in vitro release method for biodegradable microspheres. AAPS PharmSciTech 2005, 6 (2), E323-E328.
6. DŚouza, S.; De Luca, P. Methods to assess in vitro drug release from injectable polymeric particulate systems. Pharm. Res. 2006, 23 (3), 460-474.
7. Franz, T. J. Percutaneous absorption. On the relevance of in vitro data. J. Invest. Dermatol. 1975, 64, 190-195.
8. Bertram, U.; Bodmeier, R. In situ gelling, bioadhesive nasal inserts for extended drug delivery: In vitro characterization of a new nasal dosage form. Eur. J. Pharm. Sci. 2006, 27 (1), 62-71.
9. Moebus, K.; Siepmann, J.; Bodmeier, R. Alginate-poloxamer microparticles for controlled drug delivery to mucosal tissue. Eur. J. Pharm. Biopharm. 2009, 72 (1), 42-53.
10. Shameem, M.; Lee, H.; DeLuca, P. A short-term (accelerated release) approach to evaluate peptide release from PLGA depot formulations. AAPS PharmSci. 1999, 1 (3), 1-6.
11. Du, L.; Cheng, J.; Chi, Q.; Qie, J.; Liu, Y.; Mei, X. Biodegradable PLGA microspheres as a sustained release system for a new luteinizing hormone-releasing hormone (LHRH) antagonist. Chem. Pharm. Bull. 2006, 54 (9), 1259-1265.
12. Ogawa, Y.; Yamamoto, M.; Okada, H.; Yashiki, T.; Shimamoto, T. A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid. Chem. Pharm. Bull. 1988, 36 (3), 1095-1103.
13. Okada, H. One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate. Adv. Drug Deliv. Rev. 1997, 28 (1), 43-70.
14. Luan, X.; Bodmeier, R. Modification of the tri-phasic drug release pattern of leuprolide acetate-loaded poly(lactide-co-glycolide) microparticles. Eur. J. Pharm. Biopharm. 2006, 63 (2), 205-214.
15. Luan, X.; Skupin, M.; Siepmann, J.; Bodmeier, R. Key parameters affecting the initial release (burst) and encapsulation efficiency of peptide-containing poly(lactide-co-glycolide) microparticles. Int. J. Pharm. 2006, 324 (2), 168-175.
16. Faisant, N.; Akiki, J.; Siepmann, F.; Benoit, J. P.; Siepmann, J. Effects of the type of release medium on drug release from PLGA-based microparticles: Experiment and theory. Int. J. Pharm. 2006, 314 (2), 189-197.
17. Zolnik, B. S.; Burgess, D. J. Evaluation of in vivo-in vitro release of dexamethasone from PLGA microspheres. J. Control. Release 2008, 127 (2), 137-145.
18. Kumar, R.; Palmieri, M. J. Points to consider when establishing drug specifications for parenteral microspheres. AAPS J. 2010, 12 (1), 27-32.
19. Zolnik, B. S.; Burgess, D. J. Effect of acidic pH on PLGA microsphere degradation and release. J. Control. Release 2007, 122 (3), 338-344.
20. Anderson, J. M. Biological Responses to Materials. Annu. Rev. Mater. Res. 2001, 31 (1), 81-110.
21. Zolnik, B. S.; Raton, J. L.; Burgess, D. J. Application of USP Apparatus 4 and In Situ Fiber Optic Analysis to Microsphere Release Testing. Dissolution Technol. 2005, 12 (2), 11-14.
22. Voisine, J. M.; Zolnik, B. S.; Burgess, D. J. In situ fiber optic method for long-term in vitro release testing of microspheres. Int. J. Pharm. 2008, 356 (1-2), 206-211.
23. Stevenson, C. L.; Leonard, J. J.; Hall, S. C. Effect of peptide concentration and temperature on leuprolide stability in dimethyl sulfoxide. Int. J. Pharm. 1999, 191 (2), 115-129.
24. DŚouza, S. S.; Faraj, J. A.; De Luca, P. A model-dependent approach to correlate accelerated with real-time release from biodegradable microspheres. AAPS PharmSciTech 2005, 6 (4), E553-E564.
25. Faisant, N.; Siepmann, J.; Benoit, J. P. PLGA-based microparticles: elucidation of mechanisms and a new, simple mathematical model quantifying drug release. Eur. J. Pharm. Sci. 2002, 15 (4), 355-366.
26. Fu, K.; Pack, D. W.; Klibanov, A. M.; Langer, R. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm. Res. 2000, 17 (1), 100-106.
27. Li, L.; Schwendeman, S. P. Mapping neutral microclimate pH in PLGA microspheres. J. Control. Release 2005, 101 (1-3), 163-173.
28. Klose, D.; Azaroual, N.; Siepmann, F.; Vermeersch, G.; Siepmann, J. Towards More Realistic In Vitro Release Measurement Techniques for Biodegradable Microparticles. Pharm. Res. 2009, 26 (3), 691-699.