PH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride

Biomaterials

Volumn 33, Issue 29, 2012, Pages 7291-7299

  Du, Yinfeng ^a   Chen, Wei ^a   Zheng, Meng ^a   Meng, Fenghua ^a   Zhong, Zhiyuan ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Cancer therapy; Chimaeric; Doxorubicin hydrochloride; Intracellular delivery; PH sensitive; Polymersomes

Indexed keywords

CANCER THERAPY; CHIMAERIC; DOXORUBICIN HYDROCHLORIDE; INTRACELLULAR DELIVERY; PH SENSITIVE; POLYMERSOMES;

BLOCK COPOLYMERS; CARBOXYLIC ACIDS; CELL DEATH; CONFOCAL MICROSCOPY; ETHANE; LIPOSOMES; LOADING; METHANOL; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; TRANSMISSION ELECTRON MICROSCOPY;

POLYMERS;

2,4,6 TRIMETHOXYBENZYLIDENE 1,1,1 TRIS(HYDROXYMETHYL)ETHANE METHACRYLATE; ACETALDEHYDE; ACRYLIC ACID; COPOLYMER; DOXORUBICIN; LIPOSOME; MACROGOL; METHACRYLIC ACID DERIVATIVE; POLY(ETHYLENE GLYCOL) BLOCK POLY[2,4,6 TRIMETHOXYBENZYLIDENE 1,1,1 TRIS(HYDROXYMETHYL)ETHANE METHACRYLATE] BLOCK POLY(ACRYLIC ACID); POLYMER; POLYMERSOME; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASYMMETRIC SYNTHESIS; CELL VIABILITY; CHIMERA; CONCENTRATION (PARAMETERS); CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION; DISPERSION; DRUG RELEASE; ENCAPSULATION; HELA CELL; HYDROLYSIS; HYDROPHILICITY; IC 50; PARTICLE SIZE; PH; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSIBLE ADDITION FRAGMENTATION CHAIN TRANSFER COPOLYMERIZATION; STRUCTURE ANALYSIS; TOXICITY TESTING; TRANSMISSION ELECTRON MICROSCOPY;

ACRYLATES; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG DELIVERY SYSTEMS; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; METHACRYLATES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS; POLYMERS; STATIC ELECTRICITY; TEMPERATURE;

EID: 84864307789     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.06.034     Document Type: Article

References (43)

1. Peer D., Karp J.M., Hong S., FaroKhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotech 2007, 2:751-760.
2. Davis M.E., Chen Z., Shin D.M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov 2008, 7:771-782.
3. Torchilin V.P. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005, 4:145-160.
4. Tyrrell Z.L., Shen Y., Radosz M. Fabrication of micellar nanoparticles for drug delivery through the self-assembly of block copolymers. Prog Polym Sci 2010, 35:1128-1143.
5. Gaucher G., Marchessault R.H., Leroux J.C. Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes. J Control Release 2010, 143:2-12.
6. Khandare J., Minko T. Polymer-drug conjugates: progress in polymeric prodrugs. Prog Polym Sci 2006, 31:359-397.
7. Maruyama K. Intracellular targeting delivery of liposomal drugs to solid tumors based on epr effects. Adv Drug Deliv Rev 2011, 63:161-169.
8. Malam Y., Loizidou M., Seifalian A.M. Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol Sci 2009, 30:592-599.
9. LoPresti C., Lomas H., Massignani M., Smart T., Battaglia G. Polymersomes: nature inspired nanometer sized compartments. J Mater Chem 2009, 19:3576-3590.
10. Lee J.S., Feijen J. Polymersomes for drug delivery: design, formation and characterization. J Control Release 2012, 161:473-483.
11. Allen T.M., Cullis P.R. Drug delivery systems: entering the mainstream. Science 2004, 303:1818-1822.
12. Egusquiaguirre S., Igartua M., Hernández R., Pedraz J. Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research. Clin Transl Oncol 2012, 14:83-93.
13. Discher D.E., Eisenberg A. Polymer vesicles. Science 2002, 297:967-973.
14. Meng F., Zhong Z. Polymersomes spanning from nano- to microscales: advanced vehicles for controlled drug delivery and robust vesicles for virus and cell mimicking. J Phys Chem Lett 2011, 2:1533-1539.
15. Andresen T.L., Jensen S.S., Jorgensen K. Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release. Prog Lipid Res 2005, 44:68-97.
16. Ahmed F., Discher D.E. Self-porating polymersomes of peg-pla and peg-pcl: hydrolysis-triggered controlled release vesicles. J Control Release 2004, 96:37-53.
17. Christian D.A., Cai S., Bowen D.M., Kim Y., Pajerowski J.D., Discher D.E. Polymersome carriers: from self-assembly to sirna and protein therapeutics. Eur J Pharm Biopharm 2009, 71:463-474.
18. Lomas H., Canton I., MacNeil S., Du J., Armes S.P., Ryan A.J., et al. Biomimetic ph sensitive polymersomes for efficient DNA encapsulation and delivery. Adv Mater 2007, 19:4238-4243.
19. Meng F.H., Zhong Z.Y., Feijen J. Stimuli-responsive polymersomes for programmed drug delivery. Biomacromolecules 2009, 10:197-209.
20. Li M.H., Keller P. Stimuli-responsive polymer vesicles. Soft Matter 2009, 5:927-937.
21. Lee J.S., Groothuis T., Cusan C., Mink D., Feijen J. Lysosomally cleavable peptide-containing polymersomes modified with anti-EGFR antibody for systemic cancer chemotherapy. Biomaterials 2011, 32:9144-9153.
22. Meng F.H., Engbers G.H.M., Feijen J. Biodegradable polymersomes as a basis for artificial cells: encapsulation, release and targeting. J Control Release 2005, 101:187-198.
23. Ahmed F., Pakunlu R.I., Brannan A., Bates F., Minko T., Discher D.E. Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J Control Release 2006, 116:150-158.
24. Kim Y.H., Tewari M., Pajerowski J.D., Cai S.S., Sen S., Williams J., et al. Polymersome delivery of sirna and antisense oligonucleotides. J Control Release 2009, 134:132-140.
25. Choucair A., Lim Soo P., Eisenberg A. Active loading and tunable release of doxorubicin from block copolymer vesicles. Langmuir 2005, 21:9308-9313.
26. Yin H., Kang S.-W., Bae Y.H. Polymersome formation from ab2 type 3-miktoarm star copolymers. Macromolecules 2009, 42:7456-7464.
27. Gubernator J. Active methods of drug loading into liposomes: recent strategies for stable drug entrapment and increased in vivo activity. Expert Opin Drug Deliv 2011, 8:565-580.
28. Sanson C., Schatz C., Le Meins J.-F., Soum A., Thevenot J., Garanger E., et al. A simple method to achieve high doxorubicin loading in biodegradable polymersomes. J Control Release 2010, 147:428-435.
29. Liu G.J., Ma S.B., Li S.K., Cheng R., Meng F.H., Liu H.Y., et al. The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes. Biomaterials 2010, 31:7575-7585.
30. Chen W., Meng F.H., Cheng R., Zhong Z.Y. pH-sensitive degradable polymersomes for triggered release of anticancer drugs: a comparative study with micelles. J Control Release 2010, 142:40-46.
31. Griset A.P., Walpole J., Liu R., Gaffey A., Colson Y.L., Grinstaff M.W. Expansile nanoparticles: synthesis, characterization, and in vivo efficacy of an acid-responsive polymeric drug delivery system. J Am Chem Soc 2009, 131:2469-2471.
32. Thang S.H., Chong Y.K., Mayadunne R.T.A., Moad G., Rizzardo E. A novel synthesis of functional dithioesters, dithiocarbamates, xanthates and trithiocarbonates. Tetrahedron Lett 1999, 40:2435-2438.
33. Xu H.F., Meng F.H., Zhong Z.Y. Reversibly crosslinked temperature-responsive nano-sized polymersomes: synthesis and triggered drug release. J Mater Chem 2009, 19:4183-4190.
34. Gillies E.R., Jonsson T.B., Frechet J.M.J. Stimuli-responsive supramolecular assemblies of linear-dendritic copolymers. J Am Chem Soc 2004, 126:11936-11943.
35. Gillies E.R., Frechet J.M.J. A new approach towards acid sensitive copolymer micelles for drug delivery. Chem Commun 2003, 1640-1641.
36. Zhang J., Wu L., Meng F., Wang Z., Deng C., Liu H., et al. pH and reduction dual-bioresponsive polymersomes for efficient intracellular protein delivery. Langmuir 2012, 28:2056-2065.
37. Chen W., Meng F., Li F., Ji S.-J., Zhong Z. pH-responsive biodegradable micelles based on acid-labile polycarbonate hydrophobe: synthesis and triggered drug release. Biomacromolecules 2009, 10:1727-1735.
38. Liu Z.Z., Zheng M., Meng F.H., Zhong Z.Y. Non-viral gene transfection in vitro using endosomal ph-sensitive reversibly hydrophobilized polyethylenimine. Biomaterials 2011, 32:9109-9119.
39. Fritze A., Hens F., Kimpfler A., Schubert R., Peschka-Suss R. Remote loading of doxorubicin into liposomes driven by a transmembrane phosphate gradient. Biochim Biophys Acta 2006, 1758:1633-1640.
40. Ishida T., Kirchmeier M.J., Moase E.H., Zalipsky S., Allen T.M. Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human b lymphoma cells. Biochim Biophys Acta 2001, 1515:144-158.
41. Roth A., Drummond D.C., Conrad F., Hayes M.E., Kirpotin D.B., Benz C.C., et al. Anti-cd166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells. Mol Cancer Ther 2007, 6:2737-2746.
42. Elbayoumi T.A., Torchilin V.P. Enhanced cytotoxicity of monoclonal anticancer antibody 2c5-modified doxorubicin-loaded pegylated liposomes against various tumor cell lines. Eur J Pharm Sci 2007, 32:159-168.
43. Ruoslahti E., Bhatia S.N., Sailor M.J. Targeting of drugs and nanoparticles to tumors. J Cell Biol 2010, 188:759-768.