Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations

Journal of Controlled Release

Volumn 172, Issue 3, 2013, Pages 690-698

  Wang, Xinmei ^a   Yu, Bo ^a,b   Ren, Wei ^a   Mo, Xiaokui ^a   Zhou, Chenguang ^a   He, Hongyan ^a   Jia, Huliang ^c   Wang, Lu ^c   Jacob, Samson T ^a   Lee, Robert J ^a   Ghoshal, Kalpana ^a   Lee, L James ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b The Ohio State University   (United States)

^c FUDAN UNIVERSITY   (China)

Author keywords

Cationic lipid nanoparticles; Helper lipids; Hepatic delivery; microRNA; siRNA

Indexed keywords

CATIONIC LIPIDS; HEPATIC DELIVERY; LIPID NANOPARTICLES; MICRORNAS; PHYSICOCHEMICAL PROPERTY; SIRNA; TRANSFECTION ACTIVITY; TRANSFECTION EFFICIENCY;

ENZYME INHIBITION; GENE EXPRESSION; LIPIDS; LIPOSOMES; MOLECULAR BIOLOGY; NANOPARTICLES; OLEIC ACID; UNSATURATED FATTY ACIDS;

RNA;

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; MESSENGER RNA; MICRORNA; MICRORNA 122; NANOPARTICLE; OBLIMERSEN; OLEIC ACID; SMALL INTERFERING RNA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONFOCAL MICROSCOPY; CYTOPLASM; FLOW CYTOMETRY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; IN VITRO GENE TRANSFER; LIPID BILAYER; LIVER DISEASE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

CATIONIC LIPID NANOPARTICLES; HELPER LIPIDS; HEPATIC DELIVERY; MICRORNA; SIRNA;

ANIMALS; CELL LINE; HEP G2 CELLS; HUMANS; LIPIDS; LIVER; MICE; NANOPARTICLES; OLEIC ACID; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84887185103     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.09.027     Document Type: Article

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