The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles

Biomaterials

Volumn 32, Issue 31, 2011, Pages 8021-8028

  Yoshitomi, Toru ^a   Hirayama, Aki ^b   Nagasaki, Yukio ^a,c  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TSUKUBA UNIVERSITY OF TECHNOLOGY   (Japan)

^c NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

Author keywords

Antioxidant; Ischemia reperfusion; Nitroxide radical; PH responsive nanoparticle; Reactive oxygen species (ROS)

Indexed keywords

ANTIOXIDANT; ISCHEMIA REPERFUSION; NITROXIDE RADICALS; PH-RESPONSIVE; REACTIVE OXYGEN SPECIES;

BLOCK COPOLYMERS; DISEASE CONTROL; ELECTRON SPIN RESONANCE SPECTROSCOPY; HYDROPHOBICITY; MAMMALS; NANOPARTICLES; OXYGEN;

PH EFFECTS;

AMPHOPHILE; N,N,N TRIMETHYLTEMPAMINE; NITROXIDE; REACTIVE OXYGEN METABOLITE;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENVIRONMENTAL SIGNAL ENHANCED POLYMER DRUG THERAPY; HYDROPHOBICITY; IN VIVO STUDY; KIDNEY ISCHEMIA; MALE; MOLECULAR THERAPY; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTON TRANSPORT; RENAL PROTECTION;

ACUTE KIDNEY INJURY; ANIMALS; BLOOD PRESSURE; CYCLIC N-OXIDES; CYTOKINES; FREE RADICAL SCAVENGERS; HYDROGEN-ION CONCENTRATION; INFLAMMATION; KIDNEY; LIPID PEROXIDATION; MICE; MOLECULAR CONFORMATION; NANOPARTICLES; NITROGEN OXIDES; PARTICLE SIZE; PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; SUPEROXIDES; TIME FACTORS;

MUS;

EID: 80051815640     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.07.014     Document Type: Article

References (27)

1. Star R.A. Treatment of acute renal failure. Kidney Int 1998, 54:1817-1831.
2. Nath K.A., Norby S.M. Reactive oxygen species and acute renal failure. Am J Med 2000, 109:665-678.
3. Hirayama A., Nagase S., Ueda A., Oteki T., Takada K., Obara M., et al. in vivo imaging of oxidative stress in ischemia-reperfusion renal injury using electron paramagnetic resonance. Am J Physiol Ren Physiol 2005, 288:F597-F603.
4. Nilakantan V., Hilton G., Maenpaa C., Van Why S.K., Pieper G.M., Johnson C.P., et al. Favorable balance of anti-oxidant/pro-oxidant systems and ablated oxidative stress in Brown Norway rats in renal ischemia-reperfusion injury. Mol Cell Biochem 2007, 304:1-11.
5. Marchioli R., Schweiger C., Levantesi G., Tavazzi L., Valagussa F. Antioxidant vitamins and prevention of cardiovascular disease: epidemiological and clinical trial data. Lipids 2001, 36(Suppl):S53-S63.
6. Davis M.E., Chen Z.G., Shin D.M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov 2008, 7:771-782.
7. Yokoyama M., Miyauchi M., Yamada N., Okano T., Sakurai Y., Kataoka K., et al. Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res 1990, 50:1693-1700.
8. Kabanov A.V., Chekhonin V.P., Alakhov V.Yu., Batrakova E.V., Lebedev A.S., Melik-Nubarov N.S., et al. The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles: micelles as microcontainers for drug targeting. FEBS Letters 1989, 258:343-345.
9. Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986, 46:6387-6392.
10. Yamamoto Y., Nagasaki Y., Kato Y., Sugiyama Y., Kataoka K. Long-circulating poly(ethylene glycol)-poly(D, L-lactide) block copolymer micelles with modulated surface charge. J Control Release 2001, 77:27-38.
11. Nishiyama N., Okazaki S., Cabral H., Miyamoto M., Kato Y., Sugiyama Y., et al. Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res 2003, 63:8977-8983.
12. Kirpotin D.B., Drummond D.C., Shao Y., Shalaby M.R., Hong K., Nielsen U.B., et al. Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 2006, 66:6732-6740.
13. Emoto K., Nagasaki Y., Kataoka K. A Core-Shell Structured Hydrogel Thin Layer on Surfaces by Lamination of a Poly(ethylene glycol)-b-poly(D, L-lactide) Micelle and Polyallylamine. Langmuir 2000, 16:5738-5742.
14. Bae Y., Nishiyama N., Fukushima S., Koyama H., Yasuhiro M., Kataoka K. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug Chem 2005, 16:122-130.
15. Yoshitomi T., Miyamoto D., Nagasaki Y. Design of core-shell-type nanoparticles carrying stable radicals in the core. Biomacromolecules 2009, 10:596-601.
16. Yoshitomi T., Suzuki R., Mamiya T., Matsui H., Hirayama A., Nagasaki Y. pH-sensitive radical-containing-nanoparticle (RNP) for the L-band-EPR imaging of low pH circumstances. Bioconjug Chem 2009, 20:1792-1798.
17. Marushima A., Suzuki K., Nagasaki Y., Yoshitomi T., Toh K., Tsurushima H., et al. Newly synthesized radical-containing nanoparticles (RNP) Enhance Neuroprotection after Cerebral ischemia-reperfusion injury. Neurosurgery 2011, 68:1418-1426.
18. Soule B.P., Hyodo F., Matsumoto K., Simone N.L., Cook J.A., Krishna M.C., et al. The chemistry and biology of nitroxide compounds. Free Radic Biol Med 2007, 42:1632-1650.
19. Krishna M.C., Russo A., Mitchell J.B., Goldstein S., Dafni H., Samuni A. Do nitroxide antioxidants act as scavengers of O2- or as SOD mimics?. J Biol Chem 1996, 271:26026-26031.
20. Prathapasinghe G., Siow Y., Xu Z., K O. Inhibition of cystathionine-beta-synthase activity during renal ischemia-reperfusion: role of pH and nitric oxide. Am J Physiol Ren Physiol 2008, 295:F912-F922.
21. Kim J., Jung K., Park K. Reactive oxygen species differently regulate renal tubular epithelial and interstitial cell proliferation after ischemia and reperfusion injury. Am J Physiol Ren Physiol 2010, 298:F1118-F1129.
22. Hahn S.M., Sullivan F.J., DeLuca A.M., Bacher J.D., Liebmann J., Krishna M.C., et al. Hemodynamic effect of the nitroxide superoxide dismutase mimics. Free Radic Biol Med 1999, 27:529-535.
23. Patel K., Chen Y., Dennehy K., Blau J., Connors S., Mendonca M., et al. Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat. Am J Physiol Regul Integr Comp Physiol 2006, 290:R37-R43.
24. Wilcox C., Pearlman A. Chemistry and antihypertensive effects of tempol and other nitroxides. Pharmacol Rev 2008, 60:418-469.
25. Sheridan A., Bonventre J. Cell biology and molecular mechanisms of injury in ischemic acute renal failure. Curr Opin Nephrol Hypertens 2000, 9:427-434.
26. Nelson S.K., Bose S.K., McCord J.M. The toxicity of high-dose superoxide-dismutase suggests that superoxide can both initiate and terminate lipid-peroxidation in the reperfused heart. Free Radic Biol Med 1994, 16:195-200.
27. Chatterjee P.K., Cuzzocrea S., Brown P.A., Zacharowski K., Stewart K.N., Mota-Filipe H., et al. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int 2000, 58:658-673.