Newly synthesized radical-containing nanoparticles enhance neuroprotection after cerebral ischemia-reperfusion injury

Neurosurgery

Volumn 68, Issue 5, 2011, Pages 1418-1425

  Marushima, Aiki ^a   Suzuki, Kensuke ^a,c   Nagasaki, Yukio ^a,c   Yoshitomi, Toru ^a   Toh, Kazuko ^a   Tsurushima, Hideo ^a,d   Hirayama, Aki ^b   Matsumura, Akira ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TSUKUBA UNIVERSITY OF TECHNOLOGY   (Japan)

^c DOKKYO MEDICAL UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Free radical scavenger; Ischemia reperfusion injury; Ischemic brain disease; Neuroprotection; Radical containing nanoparticle

Indexed keywords

ANTIOXIDANT; HYDROETHIDINE; NANOPARTICLE; RADICAL CONTAINING NANOPARTICLE; SODIUM CHLORIDE; SUPEROXIDE; TEMPOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN NERVE CELL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; ELECTRON SPIN RESONANCE; HYPOTENSION; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MICELLE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN OXIDATION; RAT; REPERFUSION INJURY; SCORING SYSTEM; STAINING;

ANIMALS; BRAIN ISCHEMIA; CYCLIC N-OXIDES; DRUG CARRIERS; DRUG SYNERGISM; FREE RADICALS; MALE; NANOPARTICLES; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SPIN LABELS;

EID: 79955007133     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0b013e31820c02d9     Document Type: Article

References (22)

1. Hacke W, Donnan G, Fieschi C, et al. ATLANTIS Trials Investigators; ECASS Trials Investigators; NINDS rt-PA Study Group Investigators. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet. 2004;363(9411):768-774
2. The National Institute ofNeurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333(24):1581-1587.
3. Hermann DM, Matter CM. Tissue plasminogen activator-induced reperfusion injury after stroke revisited. Circulation. 2007;116(4):363-365. (Pubitemid 47196541)
4. Toledo-Pereyra LH, Lopez-Neblina F, Toledo AH. Reactive oxygen species and molecular biology ofischemia/reperfusion. Ann Transplant. 2004;9(1):81-83.
5. Folbergrová J, Zhao Q, Katsura K, Siesjö BK. N-tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc Natl Acad Sci USA. 1995;92(11):5057-5061.
6. Kato N, Yanaka K, Hyodo K, Homma K, Nagase S, Nose T. Stable nitroxide Tempol ameliorates brain injury by inhibiting lipid peroxidation in a rat model of transient focal cerebral ischemia. Brain Res. 2003;979(1-2):188-193. (Pubitemid 36792169)
7. Leker RR, Teichner A, Lavie G, Shohami E, Lamensdorf I, Ovadia H. The nitroxide antioxidant tempol is cerebroprotective against focal cerebral ischemia in spontaneously hypertensive rats. Exp Neurol. 2002;176(2):355-363. (Pubitemid 35193352)
8. Rak R, Chao DL, Pluta RM, Mitchell JB, Oldfield EH, Watson JC. Neuro-protection by the stable nitroxide Tempol during reperfusion in a rat model of transient focal ischemia. JNeurosurg. 2000;92(4):646-651. (Pubitemid 30180671)
9. Soule BP, Hyodo F, Matsumoto K, et al. The chemistry and biology ofnitroxide compounds. Free Radic Biol Med. 2007;42(11):1632-1650.
10. Ankel EG, Lai CS, Hopwood LE, Zivkovic Z. Cytotoxicity ofcommonly used nitroxide radical spin probes. Life Sci. 1987;40:495-498. (Pubitemid 17222064)
11. Hahn SM, Sullivan FJ, DeLuca AM, et al. Hemodynamic effect ofthe nitroxide superoxide dismutase mimics. Free Radic Biol Med. 1999;27(5-6):529- 535. (Pubitemid 29408638)
12. Yoshitomi T, Miyamoto D, Nagasaki Y. Design ofcore-shell-type nanoparticles carrying stable radicals in the core. Biomacromolecules. 2009;20:1792-1798.
13. Yoshitomi T, Suzuki R, Mamiya T, Matsui H, Hirayama A, Nagasaki Y. pH-sensitive radical-containing-nanoparticle (RNP) for the L-band-EPR imaging of low pH circumstances. Bioconjugete Chemistry. 2009;10:596-601.
14. Hahn SM, DeLuca AM, Coffin D, Krishna CM, Mitchell JB. In vivo radio-protection and effects on blood pressure ofthe stable free radical nitroxides. Int J Radiat Oncol Biol Phys. 1998;42(4):839-842. (Pubitemid 28559428)
15. Kuppusamy P, Wang P, Zweier JL, et al. Electron paramagnetic resonance imaging ofrat heart with nitroxide and polynitroxyl-albumin. Biochemistry. 1996;35(22):7051-7057. (Pubitemid 26182094)
16. Cuzzocrea S, McDonald MC, Mazzon E, et al. Effects oftempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury. Brain Res. 2000;875(1-2):96-106.
17. Ueda A, Nagase S, Yokoyama H, et al. Importance of renal mitochondria in the reductionofTEMPOL, anitroxideradical. Mol Cell Biochem. 2003;244(1-2):119- 124. (Pubitemid 36411062)
18. Shichinohe H, Kuroda S, Yasuda H, et al. Neuroprotective effects ofthe free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia. Brain Res. 2004;1029(2):200-206. (Pubitemid 39470176)
19. Reddy MK, Labhasetwar V. Nanoparticle-mediated delivery of superoxide dis-mutase to the brain: an effective strategy to reduce ischemia-reperfusion injury. FASEB J. 2009;23(5):1384-1395.
20. Li H, Ma L, Hsia CJ, Zweier JL, Kuppusamy P. Polynitroxyl-albumin (PNA) enhances myocardial infarction therapeutic effect oftempol in rat hearts subjected to regional ischemia-reperfusion. Free Radic Biol Med. 2002;32(8):712-719. (Pubitemid 34286592)
21. Belayev L, Busto R, Zhao W, Ginsberg MD. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res. 1996;739(1-2):88-96. (Pubitemid 26387366)
22. Grillon E, Provent P, Montigon O, Segebarth C, Rémy C, Barbier EL. Blood-brain barrier permeability to manganese and to Gd-DOTA in a rat model of transient cerebral ischaemia. NMR Biomed. 2008;21(5):427-436. (Pubitemid 351895430)