Synthesis of biocompatible, stimuli-responsive, physical gels based on ABA triblock copolymers

Biomacromolecules

Volumn 4, Issue 4, 2003, Pages 864-868

  Ma, Yinghua ^a   Tang, Yiqing ^a   Billingham, Norman C ^a   Armes, Steven P ^a   Lewis, Andrew L ^b  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b BIOCOMPATIBLES UK LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCK COPOLYMERS; FREE RADICAL POLYMERIZATION; GELS; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS (CHEMICAL);

ATOM TRANSFER RADICAL POLYMERIZATION;

MACROMOLECULES;

2 (DIETHYLAMINO)ETHYL METHACRYLATE; 2 (DIISOPROPYLAMINO)ETHYL METHACRYLATE; 2 METHACRYLOYLOXYETHYLPHOSPHORYLCHOLINE; ACID; COPOLYMER; DIPYRIDAMOLE; METHACRYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; ATOM; BIOCOMPATIBILITY; CONCENTRATION (PARAMETERS); DISSOLUTION; DRUG RELEASE; GEL; GELATION; HYDROPHOBICITY; MICELLE; MOLECULAR INTERACTION; PH; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STIMULUS; SUSTAINED DRUG RELEASE;

BIOCOMPATIBLE MATERIALS; GELS; METHACRYLATES; MICELLES; MOLECULAR STRUCTURE; PHOSPHORYLCHOLINE; POLYMERS;

EID: 0042698433     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm034118u     Document Type: Article

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21. We are, of course, aware that various thermo-responsive block copolymer gels based on Pluronic-type copolymers have been studied for at least a decade (see, for example, Ge, Y.; Deng, Y. L.; Dalton, S.; Wang, Q. G.; Attwood, D.; Price, C.; Booth, C. J. Chem. Soc., Faraday Trans. 1992, 88, 2537.
22. Yang, Z.; Pickard, S.; Deng, N. J.; Barlow, R. J.; Attwood, D.; Booth, C. Macromolecules 1994, 27, 2371). In contrast, the triblock copolymer gels described in the present work are pH-responsive and gelation is due to hydrophobic interchain interactions. In this sense, the gelation described herein is more similar to that described by Spontak and co-workers for hydrophobic ABA triblock copolymers in nonaqueous media
23. (see, Laurer, J. H.; Khan, S. A.; Spontak, R. J.; Satkowski, M. M.; Grothaus, J. T.; Smith, S. D.; Lin, J. S. Langmuir 1999, 15, 7947).The only other example of a pH-responsive gelator that we are aware of is that reported by Kops and co-workers
24. Truelsen, J. H.; Lei, M.; Kops, J.; Armes, S. P. ACS Polym. Preprints 2002, 43 (2), 257). However, in this case, gelation only occurs at relatively low pH, which makes this acidic triblock copolymer unsuitable for possible drug delivery applications. In contrast, gelation occurs at around neutral pH in the present work.
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