Reduced CCK signaling in obese-prone rats fed a high fat diet

Hormones and Behavior

Volumn 64, Issue 5, 2013, Pages 812-817

  Duca, Frank A ^a,b,c   Zhong, Li ^d,e   Covasa, Mihai ^a,b,d,f  

^a UMR1319 MICALIS   (France)

^b AGROPARISTECH   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^e HEBEI UNIVERSITY   (China)

^f STEFAN CEL MARE UNIVERSITY OF SUCEAVA   (Romania)

Author keywords

CCK 1R; Devazepide; DIO; High fat diet; Obesity

Indexed keywords

CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR ANTAGONIST; CHOLECYSTOKININ OCTAPEPTIDE; DEVAZEPIDE; MESSENGER RNA; HORMONE ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLECYSTOKININ BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; DRUG TREATMENT FAILURE; ENZYME REPRESSION; HYPERPHAGIA; LIPID DIET; MALE; NODOSE GANGLION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SATIETY; SIGNAL TRANSDUCTION; WEIGHT GAIN; ANIMAL; CCK-1R; DIO; DRUG ANTAGONISM; DRUG EFFECT; EATING; FAT INTAKE; FEEDING BEHAVIOR; HIGH-FAT DIET; METABOLISM;

CCK-1R; DEVAZEPIDE; DIO; HIGH-FAT DIET; OBESITY;

ANIMALS; CHOLECYSTOKININ; DEVAZEPIDE; DIET, HIGH-FAT; DIETARY FATS; DOWN-REGULATION; EATING; FEEDING BEHAVIOR; HORMONE ANTAGONISTS; MALE; OBESITY; RATS; SIGNAL TRANSDUCTION; SINCALIDE;

EID: 84887163697     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2013.09.004     Document Type: Article

References (52)

1. Abdelmoumene S., Gardner J.D. Cholecystokinin-induced desensitization of enzyme secretion in dispersed acini from guinea pig pancreas. Am. J. Physiol. 1980, 239:G272-G279.
2. Anini Y., Brubaker P.L. Role of leptin in the regulation of glucagon-like peptide-1 secretion. Diabetes 2003, 52:252-259.
3. Baranowska B., Radzikowska M., Wasilewska-Dziubinska E., Roguski K., Borowiec M. Disturbed release of gastrointestinal peptides in anorexia nervosa and in obesity. Diabetes Obes. Metab. 2000, 2:99-103.
4. Barrachina M.D., Martinez V., Wang L., Wei J.Y., Tache Y. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:10455-10460.
5. Berthoud H.R., Morrison C. The brain, appetite, and obesity. Annu. Rev. Psychol. 2008, 59:55-92.
6. Boyd K.A., O'Donovan D.G., Doran S., Wishart J., Chapman I.M., Horowitz M., Feinle C. High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men. Am. J. Physiol. Gastrointest. Liver Physiol. 2003, 284:G188-G196.
7. Bray G.A., Paeratakul S., Popkin B.M. Dietary fat and obesity: a review of animal, clinical and epidemiological studies. Physiol. Behav. 2004, 83:549-555.
8. Brennan I.M., Luscombe-Marsh N.D., Seimon R.V., Otto B., Horowitz M., Wishart J.M., Feinle-Bisset C. Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men. Am. J. Physiol. Gastrointest. Liver Physiol. 2012, 303:G129-G140.
9. Brenner L.A., Ritter R.C. Type A CCK receptors mediate satiety effects of intestinal nutrients. Pharmacol. Biochem. Behav. 1996, 54:625-631.
10. Brenner L.A., Ritter R.C. Intracerebroventricular cholecystokinin A-receptor antagonist does not reduce satiation by endogenous CCK. Physiol. Behav. 1998, 63:711-716.
11. Broberger C., Holmberg K., Shi T.J., Dockray G., Hokfelt T. Expression and regulation of cholecystokinin and cholecystokinin receptors in rat nodose and dorsal root ganglia. Brain Res. 2001, 903:128-140.
12. Burdyga G., Spiller D., Morris R., Lal S., Thompson D.G., Saeed S., Dimaline R., Varro A., Dockray G.J. Expression of the leptin receptor in rat and human nodose ganglion neurones. Neuroscience 2002, 109:339-347.
13. Covasa M. Deficits in gastrointestinal responses controlling food intake and body weight. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010, 299:R1423-R1439.
14. Covasa M., Ritter R.C. Rats maintained on high-fat diets exhibit reduced satiety in response to CCK and bombesin. Peptides 1998, 19:1407-1415.
15. Covasa M., Ritter R.C. Reduced sensitivity to the satiation effect of intestinal oleate in rats adapted to high-fat diet. Am. J. Physiol. 1999, 277:R279-R285.
16. Covasa M., Grahn J., Ritter R.C. High fat maintenance diet attenuates hindbrain neuronal response to CCK. Regul. Pept. 2000, 86:83-88.
17. Covasa M., Marcuson J.K., Ritter R.C. Diminished satiation in rats exposed to elevated levels of endogenous or exogenous cholecystokinin. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 280:R331-R337.
18. Dailey M.J., Moghadam A.A., Moran T.H. Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en-Y gastric bypass. Am. J. Physiol. Endocrinol. Metab. 2011, 301:E1184-E1190.
19. Daly D.M., Park S.J., Valinsky W.C., Beyak M.J. Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse. J. Physiol. 2011, 589:2857-2870.
20. de Lartigue G., Lur G., Dimaline R., Varro A., Raybould H., Dockray G.J. EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons. Endocrinology 2010, 151:3589-3599.
21. de Lartigue G., Barbier de la Serre C., Espero E., Lee J., Raybould H.E. Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons. Am. J. Physiol. Endocrinol. Metab. 2011, 301:E187-E195.
22. de Lartigue G., Barbier de la Serre C., Espero E., Lee J., Raybould H.E. Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. PLoS One 2012, 7:e32967.
23. Duca F.A., Swartz T.D., Sakar Y., Covasa M. Decreased intestinal nutrient response in diet-induced obese rats: role of gut peptides and nutrient receptors. Int. J. Obes. (Lond.) 2012, 37:375-381.
24. Duca F.A., Sakar Y., Covasa M. Combination of obesity and high-fat feeding diminishes sensitivity to GLP-1R agonist, Exendin-4. Diabetes 2013, 62:2410-2415.
25. Farley C., Cook J.A., Spar B.D., Austin T.M., Kowalski T.J. Meal pattern analysis of diet-induced obesity in susceptible and resistant rats. Obes. Res. 2003, 11:845-851.
26. Golay A., Bobbioni E. The role of dietary fat in obesity. Int. J. Obes. Relat. Metab. Disord. 1997, 21(Suppl. 3):S2-S11.
27. Guilmeau S., Buyse M., Tsocas A., Laigneau J.P., Bado A. Duodenal leptin stimulates cholecystokinin secretion: evidence of a positive leptin-cholecystokinin feedback loop. Diabetes 2003, 52:1664-1672.
28. le Roux C.W., Batterham R.L., Aylwin S.J., Patterson M., Borg C.M., Wynne K.J., Kent A., Vincent R.P., Gardiner J., Ghatei M.A., Bloom S.R. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 2006, 147:3-8.
29. Levin B.E. Developmental gene×environment interactions affecting systems regulating energy homeostasis and obesity. Front. Neuroendocrinol. 2010, 31:270-283.
30. Levin B.E., Dunn-Meynell A.A., Balkan B., Keesey R.E. Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. Am. J. Physiol. 1997, 273:R725-R730.
31. Li J., Ma W., Wang S. Slower gastric emptying in high-fat diet induced obese rats is associated with attenuated plasma ghrelin and elevated plasma leptin and cholecystokinin concentrations. Regul. Pept. 2011, 171:53-57.
32. Lieverse R.J., Masclee A.A., Jansen J.B., Lamers C.B. Plasma cholecystokinin and pancreatic polypeptide secretion in response to bombesin, meal ingestion and modified sham feeding in lean and obese persons. Int. J. Obes. Relat. Metab. Disord. 1994, 18:123-127.
33. Little T.J., Feinle-Bisset C. Effects of dietary fat on appetite and energy intake in health and obesity-oral and gastrointestinal sensory contributions. Physiol. Behav. 2011, 104:613-620.
34. Lucas F., Sclafani A. The composition of the maintenance diet alters flavor-preference conditioning by intragastric fat infusions in rats. Physiol. Behav. 1996, 60:1151-1157.
35. Matson C.A., Reid D.F., Cannon T.A., Ritter R.C. Cholecystokinin and leptin act synergistically to reduce body weight. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000, 278:R882-R890.
36. Matzinger D., Gutzwiller J.P., Drewe J., Orban A., Engel R., D'Amato M., Rovati L., Beglinger C. Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans. Am. J. Physiol. 1999, 277:R1718-R1724.
37. McLaughlin C.L., Baile C.A. Serum insulin, glucose and triglyceride response of Zucker obese and lean rats to cholecystokinin. Physiol. Behav. 1981, 26:995-999.
38. Moran T.H., Katz L.F., Plata-Salaman C.R., Schwartz G.J. Disordered food intake and obesity in rats lacking cholecystokinin A receptors. Am. J. Physiol. 1998, 274:R618-R625.
39. Morris M.J., Chen H., Watts R., Shulkes A., Cameron-Smith D. Brain neuropeptide Y and CCK and peripheral adipokine receptors: temporal response in obesity induced by palatable diet. Int. J. Obes. (Lond.) 2008, 32:249-258.
40. Nefti W., Chaumontet C., Fromentin G., Tome D., Darcel N. A high-fat diet attenuates the central response to within-meal satiation signals and modifies the receptor expression of vagal afferents in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 296:R1681-R1686.
41. Peters J.H., Karpiel A.B., Ritter R.C., Simasko S.M. Cooperative activation of cultured vagal afferent neurons by leptin and cholecystokinin. Endocrinology 2004, 145:3652-3657.
42. Reidelberger R.D., Heimann D., Kelsey L., Hulce M. Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003, 284:R389-R398.
43. Ritter R.C. Gastrointestinal mechanisms of satiation for food. Physiol. Behav. 2004, 81:249-273.
44. Savastano D.M., Covasa M. Adaptation to a high-fat diet leads to hyperphagia and diminished sensitivity to cholecystokinin in rats. J. Nutr. 2005, 135:1953-1959.
45. Sayegh A.I., Ritter R.C. Vagus nerve participates in CCK-induced Fos expression in hindbrain but not myenteric plexus. Brain Res. 2000, 878:155-162.
46. Strohmayer A.J., Smith G.P. Obese male mice (ob/ob) are normally sensitive to the satiating effect of CCK-8. Brain Res. Bull. 1986, 17:571-573.
47. Swartz T.D., Duca F.A., Covasa M. Differential feeding behavior and neuronal responses to CCK in obesity-prone and -resistant rats. Brain Res. 2010, 1308:79-86.
48. Swartz T.D., Hajnal A., Covasa M. Altered orosensory sensitivity to oils in CCK-1 receptor deficient rats. Physiol. Behav. 2010, 99:109-117.
49. Verdich C., Toubro S., Buemann B., Lysgard Madsen J., Juul Holst J., Astrup A. The role of postprandial releases of insulin and incretin hormones in meal-induced satiety-effect of obesity and weight reduction. Int. J. Obes. Relat. Metab. Disord. 2001, 25:1206-1214.
50. Williams D.L., Hyvarinen N., Lilly N., Kay K., Dossat A., Parise E., Torregrossa A.M. Maintenance on a high-fat diet impairs the anorexic response to glucagon-like-peptide-1 receptor activation. Physiol. Behav. 2011, 103:557-564.
51. Yox D.P., Brenner L., Ritter R.C. CCK-receptor antagonists attenuate suppression of sham feeding by intestinal nutrients. Am. J. Physiol. 1992, 262:R554-R561.
52. Zwirska-Korczala K., Konturek S.J., Sodowski M., Wylezol M., Kuka D., Sowa P., Adamczyk-Sowa M., Kukla M., Berdowska A., Rehfeld J.F., Bielanski W., Brzozowski T. Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome. J. Physiol. Pharmacol. 2007, 58(Suppl. 1):13-35.