Analytical workflow for rapid screening and purification of bioactives from venom proteomes

Toxicon

Volumn 76, Issue , 2013, Pages 270-281

  Otvos, Reka A ^a   Heus, Ferry ^a   Vonk, Freek J ^b,d,e   Halff, Jenny ^a   Bruyneel, Ben ^a   Paliukhovich, Iryna ^a   Smit, August B ^a   Niessen, Wilfried M A ^a,c   Kool, Jeroen ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c Hyphen MassSpec   (Netherlands)

^d BANGOR UNIVERSITY   (United Kingdom)

^e NATURALIS BIODIVERSITY CENTER   (Netherlands)

Author keywords

Lymnaea stagnalis acetylcholine binding protein (Ls AChBP); Nano liquid chromatography mass spectrometry (nano LC MS); Nicotinic acetylcholine receptor; On line microfluidics; Snake venom proteome screening; Venom purification

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINE BINDING PROTEIN; BINDING PROTEIN; BUNGAROTOXIN RECEPTOR; CYTOTOXIN 1; CYTOTOXIN 2; PROTEOME; SNAKE VENOM; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANXIETY; ARTICLE; BINDING AFFINITY; BIOASSAY; BIOCHIP; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG TARGETING; EPILEPSY; FLUORESCENCE ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NAJA MOSSAMBICA MOSSAMBICA; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PURIFICATION; SCHIZOPHRENIA; SCREENING TEST; SEQUENCE HOMOLOGY; SNAKE; WORKFLOW;

ANIMALIA; LYMNAEA STAGNALIS; NAJA MOSSAMBICA MOSSAMBICA;

(E)-3-(3-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-3,4,5,6-TETRAHYDROPYRIDIN-2-YL)PYRIDINE; ACETONITRILE; ACETYLCHOLINE BINDING PROTEIN; ACHBP; ACN; CENTRAL NERVOUS SYSTEM; CNS; DAHBA; EDA; EFFECT DIRECTED ANALYSIS; EICS; ELECTROSPRAY IONIZATION; ELISA BR; ENZYME-LINKED IMMUNOSORBENT ASSAY BLOCKING REAGENT; ESI; EXTRACTED ION CHROMATOGRAMS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH-RESOLUTION SCREENING; HPLC; HRS; I.D.; INTERNAL DIAMETER; ION-TRAP-TIME-OF-FLIGHT; IT TOF; LC; LIQUID CHROMATOGRAPHY; LS-ACHBP; LYMNAEA STAGNALIS ACETYLCHOLINE BINDING PROTEIN; LYMNAEA STAGNALIS ACETYLCHOLINE BINDING PROTEIN (LS-ACHBP); MALDI-TOF/TOF; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION WITH TANDEM TIME OF FLIGHT DETECTION; MS; NANO-LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (NANO-LC-MS); NICOTINIC ACETYLCHOLINE RECEPTOR; ON-LINE MICROFLUIDICS; PHOSPHOLIPASE A2; PLA2; Q TOF; QUADRUPOLE-TIME-OF-FLIGHT; SNAKE VENOM PROTEOME SCREENING; TFA; TFX3; THREE-FINGER TOXIN; TIC; TOTAL ION CHROMATOGRAM; TRIFLUOROACETIC ACID; VENOM PURIFICATION; Α7-NACHR; Α7-NICOTINIC ACETYLCHOLINE RECEPTOR;

ANIMALS; CHROMATOGRAPHY, LIQUID; COBRA VENOMS; MICROFLUIDICS; PROTEOME; REPTILIAN PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; WORKFLOW;

EID: 84887124469     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2013.10.013     Document Type: Article

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